M
Murielle Rinaldi-Carmona
Researcher at Sanofi S.A.
Publications - 106
Citations - 7235
Murielle Rinaldi-Carmona is an academic researcher from Sanofi S.A.. The author has contributed to research in topics: Cannabinoid receptor & Cannabinoid. The author has an hindex of 31, co-authored 106 publications receiving 7116 citations.
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Journal ArticleDOI
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Murielle Rinaldi-Carmona,Francis Barth,Michel Heaulme,David Shire,Bernard Calandra,Christian Congy,Serge Martinez,Jeanne Maruani,Gervais Neliat,Daniel Caput,P. Ferrara,Philippe Soubrie,J. C. Breliere,Gérard Le Fur +13 more
TL;DR: SR141716A is the first selective and orally active antagonist of the brain cannabinoid receptor and should prove to be a powerful tool for investigating the in vivo functions of the anandamide/cannabinoid system.
Journal Article
SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor
Murielle Rinaldi-Carmona,Francis Barth,Millan J,Jean-Marie Derocq,P. Casellas,Christian Congy,Didier Oustric,Sarran M,Monsif Bouaboula,Bernard Calandra,Marielle Portier,David Shire,J. C. Breliere,Le Fur Gl +13 more
TL;DR: It is expected that SR 144528 will provide a powerful tool to investigate the in vivo functions of the cannabinoid system in the immune response.
Journal ArticleDOI
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1
Monsif Bouaboula,Caroline Poinot-Chazel,Bernard Bourrie,Xavier Canat,Bernard Calandra,Murielle Rinaldi-Carmona,G Le Fur,P. Casellas +7 more
TL;DR: It is shown here that cannabinoid treatment induces both phosphorylation and activation of mitogen-activated protein (MAP) kinases, and that these effects are inhibited by SR 141716A, a selective CB1 antagonist.
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A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1 EVIDENCE FOR A NEW MODEL OF RECEPTOR/LIGAND INTERACTIONS
Monsif Bouaboula,Sylvie Perrachon,Laura Milligan,Xavier Canat,Murielle Rinaldi-Carmona,M. Portier,Francis Barth,Bernard Calandra,Florence Pecceu,Johannes Lupker,Jean-Pierre Maffrand,Gérard Le Fur,Pierre Casellas +12 more
TL;DR: Chinese hamster ovary cells transfected with human central cannabinoid receptor (CB1) exhibit high constitutive activity at both levels of mitogen-activated protein kinase (MAPK) and adenylyl cyclase, and the CB1-selective ligand, SR 141716A, that functions as an inverse agonist is proposed as a novel model for receptor/ligand interactions.
Journal ArticleDOI
An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing.
David Shire,Christine Carillon,Mourad Kaghad,Bernard Calandra,Murielle Rinaldi-Carmona,Gérard Le Fur,Daniel Caput,Pascual Ferrara +7 more
TL;DR: Two overlapping clones from a human lung cDNA library with CB1 cDNA inserts are isolated, showing the presence of both CB1 and CB1A throughout the brain and in all the peripheral tissues examined, withCB1A being present in amounts of up to 20% of CB1.