M
Muthusamy Thangaraju
Researcher at Georgia Regents University
Publications - 94
Citations - 8235
Muthusamy Thangaraju is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Cancer & Apoptosis. The author has an hindex of 43, co-authored 86 publications receiving 6791 citations. Previous affiliations of Muthusamy Thangaraju include McGill University & Mayo Clinic.
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Journal ArticleDOI
Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
Nagendra Singh,Ashish Gurav,Sathish Sivaprakasam,Evan Brady,Ravi Padia,Huidong Shi,Muthusamy Thangaraju,Puttur D. Prasad,Santhakumar Manicassamy,David H. Munn,Jeffrey R. Lee,Stefan Offermanns,Vadivel Ganapathy +12 more
TL;DR: This paper showed that GPR109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells.
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Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
TL;DR: This review focuses on three groups of nutrient transporters relevant to cancer: glucosetransporters, lactate transportters, and amino acid transporter, which are related to amino acid nutrition.
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GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
Muthusamy Thangaraju,Gail Cresci,Kebin Liu,Sudha Ananth,Jaya P. Gnana-Prakasam,Darren D. Browning,John D. Mellinger,Sylvia B. Smith,Gregory J. Digby,Nevin A. Lambert,Puttur D. Prasad,Vadivel Ganapathy +11 more
TL;DR: It is shown that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon and suppresses nuclear factor-kappaB activation in normal and cancer colon cell lines as well as in normal mouse colon.
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Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
Maria Ouzounova,Eunmi Lee,Raziye Piranlioglu,Abdeljabar El Andaloussi,Ravindra Kolhe,Mehmet F. Demirci,Daniela Marasco,Iskander Asm,Ahmed Chadli,Khaled A. Hassan,Muthusamy Thangaraju,Gang Zhou,Ali S. Arbab,John K. Cowell,Hasan Korkaya +14 more
TL;DR: It is demonstrated here that monocytic (mMDSC) and granulocytic subsets of myeloid-derived suppressor cells infiltrate in the primary tumour and distant organs with different time kinetics and regulate spatiotemporal tumour plasticity.
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Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.
Ujendra Kumar,Ramakrishnan Sasi,Sundar Suresh,Amit Patel,Muthusamy Thangaraju,Peter Metrakos,Shutish C. Patel,Yogesh C. Patel +7 more
TL;DR: Analysis of pattern of expression of hSSTR1-5 in normal human islet cells by quantitative double-label confocal fluorescence immunocytochemistry reveals predominant expression of SSTR1, SSTR2, and SSTR5 in human islets, which could be the basis for preferential insulin suppression by Sstr1-specific ligands and of glucagon inhibition by SStr2-selective compounds.