M
My G. Mahoney
Researcher at University of Pennsylvania
Publications - 17
Citations - 1433
My G. Mahoney is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Biology & Pemphigus vulgaris. The author has an hindex of 8, co-authored 10 publications receiving 1352 citations. Previous affiliations of My G. Mahoney include Thomas Jefferson University.
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Journal ArticleDOI
Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
My G. Mahoney,My G. Mahoney,Zhi Hong Wang,Kyle Rothenberger,Peter Koch,Peter Koch,Masayuki Amagai,John R. Stanley +7 more
TL;DR: It is suggested that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and it is demonstrated that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.
Journal ArticleDOI
Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris
Peter Koch,My G. Mahoney,Hiroyasu Ishikawa,Leena Pulkkinen,Jouni Uitto,Leonard Shultz,George F. Murphy,Diana Whitaker-Menezes,John R. Stanley +8 more
TL;DR: It is suggested that pemphigus autoantibodies might interfere directly with such a function of DSG3, and the critical importance of Dsg3 for adhesion in deep stratified squamous epithelia is demonstrated.
Journal ArticleDOI
Pemphigus vulgaris (PV) antigen (desmoglein 3) anchors telogen hair in the follicle
Peter Koch,My G. Mahoney,Kyle Rothenberger,Robert M. Layker,George Cotsarelis,John R. Stanley +5 more
TL;DR: The authors showed that desmoglein 3 is not only critical for cell adhesion in the deep stratified squamous epithelium, but also for anchoring the telogen hair to the outer root sheath of the follicle and underscore the importance of desmosomes in maintaining the normal structure and function of hair.
Journal ArticleDOI
Desmoglein 3 anchors telogen hair in the follicle
Peter Koch,My G. Mahoney,George Cotsarelis,Kyle Rothenberger,Robert M. Lavker,John R. Stanley +5 more
TL;DR: Data demonstrate that desmoglein 3 is not only critical for cell adhesion in the deep stratified squamous epithelium, but also for anchoring the telogen hair to the outer root sheath of the follicle and underscore the importance of desmosomes in maintaining the normal structure and function of hair.
Journal ArticleDOI
The Members of the Plakin Family of Proteins Recognized by Paraneoplastic Pemphigus Antibodies Include Periplakin
TL;DR: It is indicated that a homologous region in the carboxy-terminus of plakins, including the newly characterized periplakin, serves as an antigenic site in PNP.