Myron S. Cohen

Bio: Myron S. Cohen is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Population & Acquired immunodeficiency syndrome (AIDS). The author has an hindex of 103, co-authored 549 publications receiving 46021 citations. Previous affiliations of Myron S. Cohen include University of Massachusetts Medical School & Scripps Health.

Treatment of Gonococcal Osteomyelitis

Abstract: To the Editor— We refer to the article by Drs Tindall and Regan-Smith 1 on gonococcal osteomyelitis We have recently reported an additional case 2 and reviewed three other cases not described in their article Although gonococci that produce disseminated infections are usually exquisitely sensitive to penicillin, two of these additional cases of gonococcal osteomyelitis were caused by β-lactamase-producing strains 3,4 This observation calls attention to two points: (1) The setting of acute, asymmetric pauciarticular arthritis in a sexually active patient is complex While the response of patients with gonococcal arthritis to penicillin is usually dramatic, failure to respond may not absolutely exclude the diagnosis (2) Empiric therapy with cefoxitin or cefotaxime 5 may be indicated for patients with presumed gonococcal arthritis or osteomyelitis who do not respond rapidly to penicillin and who may have had sexual exposure in areas where β-lactamase-producing gonococci have been isolated

Some observations on yugoslavia and china

Abstract: Based on fieldwork in Yugoslavia and China. we compare medicine in two societies which are attempting to construct their own unique paths to socialism. After a brief description of each country and its sociopolitical system, we sketch the broad outlines of the health care system which has evolved. We then discuss certain constraints on achieving the socialist objectives of equality of access to health care and democratization of the patient-clinician relationship. In a concluding section, we summarize some of the similarities and differences in medicine under Yugoslav and Chinese socialism, respectively.

A Fatal Eosinophilic Process in a Laotian Refugee

Abstract: A 17-year-old Laotian refugee developed an ultimately fatal disease process characterized by formation of an abdominal eosinophilic mass, peripheral eosinophilia, and elevated serum IgE. No parasitic pathogens that could explain her disease were isolated during life or identified at autopsy. Furthermore, the disease was not consistent with previously described neoplastic, inflammatory, or idiopathic diseases. We believe this process represents a unique, aggressive variation of the hypereosinophilic syndrome, and that immunosuppressive therapy may be warranted.

Outpatient antibiotic therapy for osteomyelitis.

Abstract: To the Editor.— The March 28, 1986, issue ofJAMAcontained an article offering an economic analysis of outpatient therapy for osteomyelitis.1This article is now being distributed by representatives of the Smith Klein & French pharmaceutical company for the purpose of encouraging the use of the cephalosporin antibiotic cefonicid (Monocid) in this setting. In their introduction, the authors justify their analysis by noting that "a new... cephalosporin antibiotic, cefonicid sodium, has been shown to be effective in treating osteomyelitis in the outpatient setting." This statement is supported by reference to a clinical trial published in a supplement toReviews of Infectious Diseasesunderwritten by Smith Klein & French.2This clinical trial examined (in an uncontrolled fashion) cefonicid therapy for osteomyelitis in 15 patients, 12 of whom completed therapy. The investigators in this clinical trial appropriately noted the limitations of their study: small numbers, no comparison group, lack

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

Abstract: Background Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. Methods In nine countries, we...

Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults

Abstract: Lionel A. Mandell, Richard G. Wunderink, Antonio Anzueto, John G. Bartlett, G. Douglas Campbell, Nathan C. Dean, Scott F. Dowell, Thomas M. File, Jr. Daniel M. Musher, Michael S. Niederman, Antonio Torres, and Cynthia G. Whitney McMaster University Medical School, Hamilton, Ontario, Canada; Northwestern University Feinberg School of Medicine, Chicago, Illinois; University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, and Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi School of Medicine, Jackson; Division of Pulmonary and Critical Care Medicine, LDS Hospital, and University of Utah, Salt Lake City, Utah; Centers for Disease Control and Prevention, Atlanta, Georgia; Northeastern Ohio Universities College of Medicine, Rootstown, and Summa Health System, Akron, Ohio; State University of New York at Stony Brook, Stony Brook, and Department of Medicine, Winthrop University Hospital, Mineola, New York; and Cap de Servei de Pneumologia i Allergia Respiratoria, Institut Clinic del Torax, Hospital Clinic de Barcelona, Facultat de Medicina, Universitat de Barcelona, Institut d’Investigacions Biomediques August Pi i Sunyer, CIBER CB06/06/0028, Barcelona, Spain.

Role of free radicals and catalytic metal ions in human disease: an overview.

Abstract: Publisher Summary This chapter discusses the role of free radicals and catalytic metal ions in human disease. The importance of transition metal ions in mediating oxidant damage naturally leads to the question as to what forms of such ions might be available to catalyze radical reactions in vivo . The chapter discusses the metabolism of transition metals, such as iron and copper. It also discusses the chelation therapy that is an approach to site-specific antioxidant protection. The detection and measurement of lipid peroxidation is the evidence most frequently cited to support the involvement of free radical reactions in toxicology and in human disease. A wide range of techniques is available to measure the rate of this process, but none is applicable to all circumstances. The two most popular are the measurement of diene conjugation and the thiobarbituric acid (TBA) test, but they are both subject to pitfalls, especially when applied to human samples. The chapter also discusses the essential principles of the peroxidation process. When discussing lipid peroxidation, it is essential to use clear terminology for the sequence of events involved; an imprecise use of terms such as initiation has caused considerable confusion in the literature. In a completely peroxide-free lipid system, first chain initiation of a peroxidation sequence in a membrane or polyunsaturated fatty acid refers to the attack of any species that has sufficient reactivity to abstract a hydrogen atom from a methylene group.

Regression Diagnostics: Identifying Influential Data and Sources of Collinearity

Abstract: 1. Introduction and Overview. 2. Detecting Influential Observations and Outliers. 3. Detecting and Assessing Collinearity. 4. Applications and Remedies. 5. Research Issues and Directions for Extensions. Bibliography. Author Index. Subject Index.

Sexually transmitted diseases treatment guidelines.

Abstract: The MMWR series of publications is published by the Office of Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333.