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N.D. Sinha
Researcher at University of Hamburg
Publications - 5
Citations - 1158
N.D. Sinha is an academic researcher from University of Hamburg. The author has contributed to research in topics: Oligonucleotide synthesis & Oligonucleotide. The author has an hindex of 5, co-authored 5 publications receiving 1149 citations.
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Journal ArticleDOI
Polymer support oligonucleotide synthesis XVIII1.2): use of β-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product
TL;DR: Various 5'O-N-protected deoxynucleoside-3'-O-beta-cyanoethyl-N,N-dialkylamino-/N- morpholinophosphoramidites were prepared from beta-Cyanoethyl monochlorophosphors of N, N-dimethylamine, N, n-diisopropylamine and N-morpholine to provide stability in solution for automated DNA-synthesis.
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β-Cyanoethyl N,N-dialkylamino/N-morpholinomonochloro phosphoamidites, new phosphitylating agents facilitating ease of deprotection and work-up of synthesized oligonucleotides
TL;DR: In this article, β-Cyanoethyl monochlorophosphoamidites of the secondary amines N, N-dmethylamine, N,N-diisopropylamine and morpholine have been prepared which showed quantitative phosphitylation of the protected deoxynucleosides.
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Polymer support oligonucleotide synthesis-XV: Synthesis of oligodeoxynucleotides on controlled pore glass (CPG) using phosphate and a new phosphite triester approach☆☆☆
TL;DR: In this paper, controlled pore glass (CPG) has been functionalized with suitably protected deoxynucleosides and used to synthesize d(TTTATT) and d(CATCAGGAAGT) following the phosphate triester approach with 1-(mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole (MSNT) as condensing agent and ZnBr2; as detritylating agent.
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A new synthesis of oligodeoxynucleoside methylphosphonates on control pore glass polymer support using phosphite approach
TL;DR: In this paper, the trimer and tetramer blocks of deoxynucleoside methylphosphonodiesters d(AC, d(AT), D(ATG) and T4-polynucleotide kinase were synthesized on CPG polymer support using deoxynaucleosides methylphphosphonomonochloridite.
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Polymer Support Oligonucleotide Synthesis XVI: Synthesis of Oligonucleotides Using Suitably Protected Deoxynucleoside-N-morpholinophosphoramidites on Porous Glass Beads
TL;DR: Several oligodeoxynucleotides had been synthesized on controlled pore glass beads using pure and stable 3′-O(5′)-O, N-protected nucleoside-methyl-N-morpholino phosphoramidites as mentioned in this paper.