Author
N Midoux
Bio: N Midoux is an academic researcher from École nationale supérieure des industries chimiques. The author has contributed to research in topics: Jet (fluid) & Jet mill. The author has an hindex of 1, co-authored 1 publications receiving 116 citations.
Topics: Jet (fluid), Jet mill
Papers
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TL;DR: In this paper, the authors present results on organic crystals' jet milling in terms of specific energy consumption with an adaptation of the correlation proposed by Sarma, showing that, within the operating energy range and above a critical energy value, the creation of specific surface area corresponds to an increase of fine particles production.
131 citations
Cited by
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TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.
773 citations
TL;DR: A comprehensive state‐of‐the‐art review on scCO2‐based processes focused on the formation and on the control of the physicochemical, structural and morphological properties of amorphous/crystalline pure drug nanoparticles.
164 citations
TL;DR: The results demonstrated that the controlled nanoprecipitation method is a direct and feasible technology which could be utilized for preparation of the poorly water-soluble pharmaceutical nanoparticles.
156 citations
TL;DR: The surface modified, micronized powders showed improved dispersion, higher bulk densities, reduced electrostatic, and higher flowability, indicating they may be used in high drug loaded formulations amenable to direct compression.
144 citations
TL;DR: Amorphous nanoparticles of cefuroxime axetil (CFA), a kind of poorly water-soluble antibiotic drug, were prepared at massive production rate by a novel continuous process, the high-gravity antisolvent precipitation (HGAP), which was characterized by scanning electron microscopy, Fourier transform infrared spectrophotometry (FTIR), powder X-ray diffraction (XRD), specific surface area analysis (BET), differential scanning calorimetry (DSC), and a dissolution test as mentioned in this paper.
Abstract: Amorphous nanoparticles of cefuroxime axetil (CFA), a kind of poorly water-soluble antibiotic drug, were prepared at massive production rate by a novel continuous process, the high-gravity antisolvent precipitation (HGAP). The produced CFA nanoparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FTIR), powder X-ray diffraction (XRD), specific surface area analysis (BET), differential scanning calorimetry (DSC), and a dissolution test. The mean particle size of CFA was about 300 nm with a narrow distribution from 100 to 400 nm. The specific surface area reached up to 8.67 m2/g, which was about 4 times higher than that of the commercial spray-dried CFA. And the results of the dissolution test showed that dissolution rate of the former were higher than that of the latter. Hence it is proved the HGAP technique offers a direct and continuous process for mass-production of drug nanoparticles.
103 citations