N
N. V. Bovin
Researcher at Russian Academy of Sciences
Publications - 116
Citations - 3647
N. V. Bovin is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Virus & Hemagglutinin (influenza). The author has an hindex of 27, co-authored 116 publications receiving 3441 citations. Previous affiliations of N. V. Bovin include Russian Academy & Auckland University of Technology.
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Journal ArticleDOI
Early Alterations of the Receptor-Binding Properties of H1, H2, and H3 Avian Influenza Virus Hemagglutinins after Their Introduction into Mammals
Mikhail Matrosovich,Alexander B. Tuzikov,N. V. Bovin,A.S. Gambaryan,Alexander Klimov,Maria R. Castrucci,Isabella Donatelli,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Yoshihiro Kawaoka +9 more
TL;DR: The results show that the receptor-binding specificity of the HA is altered early after the transmission of an avian virus to humans and pigs and, therefore, may be a prerequisite for the highly effective replication and spread which characterize epidemic strains.
Journal ArticleDOI
Balanced hemagglutinin and neuraminidase activities are critical for efficient replication of influenza a virus
Lyndon J. Mitnaul,Mikhail Matrosovich,Mikhail Matrosovich,Maria R. Castrucci,Alexander B. Tuzikov,N. V. Bovin,Darwyn Kobasa,Yoshihiro Kawaoka,Yoshihiro Kawaoka +8 more
TL;DR: The SD0 mutant of influenza virus A/WSN/33 (WSN), characterized by a 24-amino-acid deletion in the neuraminidase stalk, does not grow in embryonated chicken eggs because of defective NA function, demonstrating that balanced HA-NA functions are necessary for efficient influenza virus replication.
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Specification of Receptor-Binding Phenotypes of Influenza Virus Isolates from Different Hosts Using Synthetic Sialylglycopolymers: Non-Egg-Adapted Human H1 and H3 Influenza A and Influenza B Viruses Share a Common High Binding Affinity for 6′-Sialyl(N-acetyllactosamine)
A S Gambaryan,A. B. Tuzikov,V. E. Piskarev,S. S. Yamnikova,D. K. Lvov,James S. Robertson,N. V. Bovin,Mikhail Matrosovich +7 more
TL;DR: The data show that sialylglycopolymers may become a useful tool in studies on molecular mechanisms of interspecies transfer, tissue specificity, and other structure-function relationships of the influenza virus hemagglutinin.
Journal ArticleDOI
Probing of the receptor-binding sites of the H1 and H3 influenza A and influenza B virus hemagglutinins by synthetic and natural sialosides.
Mikhail Matrosovich,A.S. Gambaryan,A. B. Tuzikov,N. E. Byramova,L.V. Mochalova,Alexander Golbraikh,Mark D. Shenderovich,Jukka Finne,N. V. Bovin +8 more
TL;DR: While the functional groups of Neu5Ac studied are recognized by the RBSs of all influenza viruses, the magnitude of their contribution to the binding energy, as well as the contribution of the asialic portion of the receptor, may vary in dependence upon the virus type, subtype, and strain.
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Synthetic polymeric sialoside inhibitors of influenza virus receptor-binding activity
TL;DR: Anomeric aminobenzylglycosides of Neu5Ac were coupled with the polyacrylate carrier and a number of synthetic polyvalent sialosides obtained were investigated as inhibitors of influenza virus attachment.