Na Qiao

TL;DR: Using tissue microarrays containing 105 triple-negative breast cancer specimens, Mittendorf and colleagues show that 20% of the TNBC specimens express PD-L1, half have lost PTEN, and inhibitors of PI3K pathway decrease PD- l1 expression, providing a rationale for therapeutic targeting of PD- L1 for TNBC.

TL;DR: A novel role of autophagy is suggested in the enhanced cytotoxicity by cell cycle inhibition after genotoxic injury in tumor cells in sarcoma cell lines.

TL;DR: It is concluded that HER2-positive breast cancer patients that have been treated with trastuzumab may experience a more robust antitumor immune response by restimulation of T cells with the E75 peptide vaccine, thereby accounting for the improved disease-free survival observed with combination therapy.

TL;DR: An investigation of the pathobiologic basis for the prognostic significance of neutrophil elastase in a model of cyclin E-overexpressing breast cancer reveals a previously unknown mechanism of antitumor adaptive immunity that links cancer cell uptake of an inflammatory mediator to an effective cytolytic response against an important breast cancer antigen.

TL;DR: Studies show that HER2-mediated signaling effects LMW cyclin E expression, which in turn deregulates the cell cycle, warranting further study of its potential as a therapeutic target.