Naama Barkai

TL;DR: Deviation of coexpressed genes from this general trend, including high noise in stress-related genes and low noise in proteasomal genes, may indicate fluctuations in pathway-specific regulators or a differential activation pattern of the underlying gene promoters.

TL;DR: It is found that the BMP activation gradient itself is robust to changes in gene dosage, and it is shown experimentally that Dpp is widely diffusible in the presence of Sog but tightly localized in its absence, thus validating a central prediction of the theoretical study.

TL;DR: It is shown analytically that for noisy expression data the proposed approach leads to better classification due to the implementation of the threshold, and argues that the method is in fact a generalization of singular value decomposition, which corresponds to the special case where no threshold is applied.

TL;DR: The connection between patterns of nucleosome occupancy and the capacity to modulate gene expression upon changing conditions, i.e., transcriptional plasticity, is examined and two distinct strategies for gene regulation by chromatin are suggested, which are selectively employed by different genes.

TL;DR: Compared the allele-specific expression of two yeast species and their hybrid, which allowed us to distinguish changes in regulatory sequences of the gene itself (cis) from changes in upstream regulatory factors (trans), insights are provided on the regulatory changes in cis and trans during the divergence of species and upon hybridization.