N
Naazneen Moolla
Researcher at University of the Witwatersrand
Publications - 7
Citations - 344
Naazneen Moolla is an academic researcher from University of the Witwatersrand. The author has contributed to research in topics: Medicine & Hepatitis B virus. The author has an hindex of 4, co-authored 4 publications receiving 327 citations.
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Journal ArticleDOI
Regulatory elements of hepatitis B virus transcription
TL;DR: This review outlines the major HBV transcription regulatory elements and highlights the reliance of accurate HBV gene modulation on the complex interplay between several trans‐acting factors and their corresponding cis‐ motifs in the viral genome.
Journal ArticleDOI
Effective Inhibition of HBV Replication in Vivo by Anti-HBx Short Hairpin RNAs
Sergio Carmona,Abdullah Ely,Carol Crowther,Naazneen Moolla,Felix H. Salazar,Patricia L. Marion,Nicolas Ferry,Marc S. Weinberg,Patrick Arbuthnot +8 more
TL;DR: Observations indicate that U6 shRNA 5 and U6ShRNAs 6 are promising candidates for therapy of chronic HBV infection.
Journal ArticleDOI
The rare TXNRD1_v3 ("v3") splice variant of human thioredoxin reductase 1 protein is targeted to membrane rafts by N-acylation and induces filopodia independently of its redox active site integrity.
TL;DR: The results identify v3 as an intricately regulated protein that expands TXNRD1-derived protein functions to the membrane raft compartment, and imply that v3, shown to be targeted to membrane rafts, may be involved in signaling events.
Journal ArticleDOI
Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entry.
TL;DR: Changes in the extracellular redox environment may represent a signal for translocation of CD4 into DRM clusters, and this sequestration is another potential mechanism by which the anti-HIV effects of cell surface oxidoreductase inhibition are exerted.
Journal ArticleDOI
Tanapox, South Africa, 2022
Monica Birkhead,Wayne Grayson,Antoinette A. Grobbelaar,Veerle Msimang,Naazneen Moolla,Angela Mathee,Lucille Blumberg,T. Marshall,Daniel M. Morobadi,Mirjana Popara,Jacqueline Weyer +10 more
TL;DR: Tanapox is a rarely diagnosed zoonosis known to be endemic to equatorial Africa and all previously reported human cases were acquired within 10° north or south of the Equator, most recently 19 years ago as mentioned in this paper .