Nabil Elshourbagy

TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.

TL;DR: expression analysis by quantitative reverse transcription-PCR showed that GPR40 was specifically expressed in brain and Pancreas, with expression in rodent pancreas being localized to insulin-producing β-cells.

TL;DR: High potency agonism was evident from peptides derived from the gene KiSS-1, the expression of which prevents metastasis in melanoma cells, and the nature of the putative cognate ligand for AXOR12 are discussed.

TL;DR: The identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor, the most potent mammalian vasoconstrictor identified so far.

TL;DR: The identification of the G protein-coupled receptor HM74 as a low affinity receptor for nicotinic acid and the subsequent identification of HM74A in follow-up bioinformatics searches and demonstrate that it acts as a high affinity receptors for Nicotinic Acid and other compounds with related pharmacology.