Nadav Cohen

TL;DR: An automated massively parallel single-cell RNA sequencing approach for analyzing in vivo transcriptional states in thousands of single cells is introduced and provides the ability to perform a bottom-up characterization of in vivo cell-type landscapes independent of cell markers or prior knowledge.

TL;DR: This work comprehensively map myeloid progenitor subpopulations by transcriptional sorting of single cells from the bone marrow, showing unexpected transcriptional priming toward seven differentiation fates but no progenitors with a mixed state.

TL;DR: The pattern of metagenomic sequencing read coverage for different microbial genomes contains a single trough and a single peak, the latter coinciding with the bacterial origin of replication, and the ratio of sequencing coverage between the peak and trough provides a quantitative measure of a species’ growth rate.

TL;DR: The crystal structure of GP1 from Lassa virus is reported, which is the first representative GP1 structure for Old World arenaviruses, and a unique triad of histidines forms a binding site for LAMP1, a known lysosomal protein recently discovered to be a critical receptor for internalized LassA virus at acidic pH.