N
Nadav Myers
Researcher at Weizmann Institute of Science
Publications - 11
Citations - 210
Nadav Myers is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Proteasome & Intrinsically disordered proteins. The author has an hindex of 6, co-authored 10 publications receiving 140 citations.
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Oncogenic addiction to high 26S proteasome level.
TL;DR: It is validated in a large number of cancer cell lines and found that partial reduction of the 26S proteasome level impairs viability in all cancer cells examined and was not correlated with cell doubling time or reduction efficiency.
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NADH Binds and Stabilizes the 26S Proteasomes Independent of ATP
Peter Tsvetkov,Nadav Myers,Raz Eliav,Yaarit Adamovich,Tzachi Hagai,Julia Adler,Ami Navon,Yosef Shaul +7 more
TL;DR: The newly identified NADH binding of 26S proteasomes advances the understanding of the molecular mechanisms of protein degradation and highlights a new link between protein homeostasis and the cellular metabolic/redox state.
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Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates
TL;DR: A simple experimental strategy to improve IDPs identification is demonstrated and it is shown that thermo-resistant proteins are preferred 20S proteasome substrates and the IUPred was used as the IDPs predicting software.
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The Disordered Landscape of the 20S Proteasome Substrates Reveals Tight Association with Phase Separated Granules.
TL;DR: It is found that low complexity proteins with prion‐like domain (PrLD), which interact with GR or PR di‐peptide repeats, are the most preferential 20S CP substrates, which suggests roles of the 20SCP in gene transcription and formation of phase‐separated granules.
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Recruitment of DNA Repair MRN Complex by Intrinsically Disordered Protein Domain Fused to Cas9 Improves Efficiency of CRISPR-Mediated Genome Editing
TL;DR: The chimeric Cas9 constructs were two times more efficient in homology-directed editing of endogenous loci in tissue culture cells and the strategy was highly efficient in restoring a genetic defect in a cell line, exemplifying the possible implementation of the strategy in gene therapy.