N
Nadine Krämer
Researcher at University of Mainz
Publications - 4
Citations - 40
Nadine Krämer is an academic researcher from University of Mainz. The author has contributed to research in topics: Human cytomegalovirus & Mutant. The author has an hindex of 2, co-authored 2 publications receiving 19 citations.
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Journal ArticleDOI
The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation.
Christine Zimmermann,Nicole Büscher,Steffi Krauter,Nadine Krämer,Uwe Wolfrum,Elisabeth Sehn,Stefan Tenzer,Bodo Plachter +7 more
TL;DR: PUL25 is added as another HCMV tegument protein that interferes with the intrinsic immunity of the host cell and may also provide a new avenue for the use of pUL25-negative strains for vaccine production.
Journal ArticleDOI
Autophagy interferes with human cytomegalovirus genome replication, morphogenesis, and progeny release.
Christine Zimmermann,Nadine Krämer,Steffi Krauter,Dennis Strand,Elisabeth Sehn,Uwe Wolfrum,Anja Freiwald,Falk Butter,Bodo Plachter +8 more
TL;DR: It is found that proteins of the autophagy machinery localize to cytoplasmic viral assembly compartments and enveloped virions in the cy toplasm of HCMV virions.
Journal ArticleDOI
An Attenuated Strain of Human Cytomegalovirus for the Establishment of a Subviral Particle Vaccine
Steffi Krauter,Nicole Büscher,Eric Bräuchle,Samira Ortega Iannazzo,Inessa Penner,Nadine Krämer,Patricia Gogesch,Simone Thomas,Marina Kreutz,Mario Dejung,Anja Freiwald,Falk Butter,Zoe Waibler,Bodo Plachter +13 more
TL;DR: This comprehensive data set shows that TR-VAC is an optimal attenuated seed virus strain for the production of a subviral dense bodies vaccine to be tested in clinical studies.
Journal ArticleDOI
Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses
Nadine Krämer,Martin Schütz,Uxía Gestal Mato,Lina Herhaus,Manfred Marschall,Christine Zimmermann +5 more
TL;DR: The human cytomegalovirus (HCMV) is a member of the beta-herpesvirus family and inflicts life-long latent infections in its hosts and off-target effects of 3MB-PP1 on several cellular processes should be considered with this approach.