N
Nadine Van Roy
Researcher at Ghent University
Publications - 158
Citations - 25878
Nadine Van Roy is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & Fluorescence in situ hybridization. The author has an hindex of 44, co-authored 153 publications receiving 23415 citations. Previous affiliations of Nadine Van Roy include Ghent University Hospital & European Organisation for Research and Treatment of Cancer.
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Journal ArticleDOI
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
Jo Vandesompele,Katleen De Preter,Filip Pattyn,Bruce Poppe,Nadine Van Roy,Anne De Paepe,Franki Speleman +6 more
TL;DR: The normalization strategy presented here is a prerequisite for accurate RT-PCR expression profiling, which opens up the possibility of studying the biological relevance of small expression differences.
Journal ArticleDOI
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
Jan Van Deun,Pieter Mestdagh,Patrizia Agostinis,Özden Akay,Sushma Anand,Jasper Anckaert,Zoraida Andreu Martinez,Tine Baetens,Els Beghein,Laurence Bertier,Geert Berx,Janneke Boere,Stephanie Boukouris,Michel Bremer,Dominik Buschmann,James Brian Byrd,Clara Casert,Lesley Cheng,Anna Cmoch,Delphine Daveloose,Eva De Smedt,Seyma Demirsoy,Victoria Depoorter,Bert Dhondt,Tom A. P. Driedonks,Aleksandra M. Dudek,Abdou ElSharawy,Ilaria Floris,Andrew D Foers,Kathrin Gärtner,Abhishek D. Garg,Edward Geeurickx,Jan Gettemans,Farzaneh Ghazavi,Bernd Giebel,Tom Groot Kormelink,Grace V. Hancock,Hetty Helsmoortel,Andrew F. Hill,Vincent Hyenne,Hina Kalra,David Kim,Joanna Kowal,Joanna Kowal,Sandra Kraemer,Petra Leidinger,Carina Leonelli,Yaxuan Liang,Lien Lippens,Shu Liu,Alessandra Lo Cicero,Alessandra Lo Cicero,Shaun Martin,Suresh Mathivanan,Prabhu Mathiyalagan,Tamás Matusek,Gloria Milani,Marta Monguió-Tortajada,Liselot Mus,Dillon C. Muth,Andrea Németh,Esther N. M. Nolte-‘t Hoen,Lorraine O'Driscoll,Roberta Palmulli,Roberta Palmulli,Michael W. Pfaffl,Bjarke Primdal-Bengtson,Bjarke Primdal-Bengtson,Erminia Romano,Quentin Rousseau,Susmita Sahoo,Natalia G. Sampaio,Monisha Samuel,Benjamin J. Scicluna,Bieke Soen,Anneleen Steels,Johannes V. Swinnen,Maarit Takatalo,Safia Thaminy,Clotilde Théry,Clotilde Théry,Joeri Tulkens,Isabel Van Audenhove,Susanne G. van der Grein,Alan Van Goethem,Martijn J. C. van Herwijnen,Guillaume van Niel,Guillaume van Niel,Nadine Van Roy,Alexander R. van Vliet,Niels Vandamme,Suzanne Vanhauwaert,Glenn Vergauwen,Frederik J. Verweij,Frederik J. Verweij,Annelynn Wallaert,Marca H. M. Wauben,Kenneth W. Witwer,Marijke I. Zonneveld,Olivier De Wever,Jo Vandesompele,An Hendrix +101 more
TL;DR: It is argued that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments and EV-TRACK, a crowdsourcing knowledgebase that centralizes EV biology and methodology, is described.
Journal ArticleDOI
Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects.
Ludwine Messiaen,Tom Callens,Geert Mortier,Diane Beysen,Ina Vandenbroucke,Nadine Van Roy,Frank Speleman,Anne De Paepe +7 more
TL;DR: The data suggest that exons 10a‐10c and 37 are mutation‐rich regions and that together with some recurrent mutations they may account for almost 30% of the mutations in classical NF1 patients, and that it remains possible that a truncated neurofibromin is formed.
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Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations.
Yao-Cheng Lin,Morgane Boone,Leander Meuris,Irma Lemmens,Nadine Van Roy,Arne Soete,Joke Reumers,Matthieu Moisse,Stéphane Plaisance,Radoje Drmanac,Jason Chen,Franki Speleman,Diether Lambrechts,Yves Van de Peer,Jan Tavernier,Nico Callewaert +15 more
TL;DR: It is observed that copy number alteration detection could identify the genomic region that enabled cell survival under selective conditions (i.c. ricin selection) and this resource enables novel and more informed studies with 293 cells, and the sequenced cell lines are distributed.
Journal ArticleDOI
Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.
Jan Hellemans,Olena Preobrazhenska,Andy Willaert,Philippe Debeer,Peter Verdonk,Teresa Costa,Katrien Janssens,Björn Menten,Nadine Van Roy,Stefan Vermeulen,Ravi Savarirayan,Wim Van Hul,Filip Vanhoenacker,Danny Huylebroeck,Anne De Paepe,Jean-Marie Naeyaert,Jo Vandesompele,Frank Speleman,Kristin Verschueren,Paul Coucke,Geert Mortier +20 more
TL;DR: In this study, LEMD3 interacted with BMP and activin-TGFβ receptor–activated Smads and antagonized both signaling pathways in human cells and interacted with XMAN1, the Xenopus laevis ortholog, which antagonizes BMP signaling during embryogenesis.