N
Nadine Waldschmitt
Researcher at Technische Universität München
Publications - 26
Citations - 3603
Nadine Waldschmitt is an academic researcher from Technische Universität München. The author has contributed to research in topics: Gut flora & Immune system. The author has an hindex of 13, co-authored 22 publications receiving 2492 citations. Previous affiliations of Nadine Waldschmitt include French Institute of Health and Medical Research & university of lille.
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Journal ArticleDOI
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Marie Vétizou,Marie Vétizou,Marie Vétizou,Jonathan M. Pitt,Jonathan M. Pitt,Jonathan M. Pitt,Romain Daillère,Romain Daillère,Romain Daillère,Patricia Lepage,Nadine Waldschmitt,Caroline Flament,Caroline Flament,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Bertrand Routy,Maria Paula Roberti,Maria Paula Roberti,Connie P.M. Duong,Connie P.M. Duong,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Antoine Roux,Antoine Roux,Antoine Roux,Sonia Becharef,Sonia Becharef,Silvia C. Formenti,Encouse B. Golden,Sascha Cording,Gérard Eberl,Andreas Schlitzer,Florent Ginhoux,Sridhar Mani,Takahiro Yamazaki,Takahiro Yamazaki,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,David Enot,David Enot,Marion Bérard,Jérôme Nigou,Jérôme Nigou,Paule Opolon,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Paul Louis Woerther,Elisabeth Chachaty,Nathalie Chaput,Nathalie Chaput,Caroline Robert,Caroline Robert,Christina Mateus,Guido Kroemer,Didier Raoult,Ivo G. Boneca,Ivo G. Boneca,Franck Carbonnel,Mathias Chamaillard,Laurence Zitvogel +60 more
TL;DR: A key role is revealed for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade, which is found to depend on distinct Bacteroides species in mice and patients.
Journal ArticleDOI
Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
Romain Daillère,Romain Daillère,Romain Daillère,Marie Vétizou,Marie Vétizou,Marie Vétizou,Nadine Waldschmitt,Takahiro Yamazaki,Takahiro Yamazaki,Christophe Isnard,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Connie P.M. Duong,Connie P.M. Duong,Caroline Flament,Caroline Flament,Patricia Lepage,Maria Paula Roberti,Maria Paula Roberti,Bertrand Routy,Bertrand Routy,Bertrand Routy,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,Lionel Apetoh,Lionel Apetoh,Sonia Becharef,Sonia Becharef,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Philippe Langella,Harry Sokol,Harry Sokol,Guido Kroemer,David Enot,Antoine Roux,Alexander M. M. Eggermont,Alexander M. M. Eggermont,Eric Tartour,Ludger Johannes,Ludger Johannes,Ludger Johannes,Paul Louis Woerther,Elisabeth Chachaty,Jean-Charles Soria,Jean-Charles Soria,Encouse B. Golden,Silvia C. Formenti,Magdalena Plebanski,Mutsa Tatenda Madondo,Philip Rosenstiel,Didier Raoult,Vincent Cattoir,Ivo G. Boneca,Mathias Chamaillard,Laurence Zitvogel +57 more
TL;DR: Enterococcus hirae and B. intestinihominis represent valuable "oncomicrobiotics" ameliorating the efficacy of the most common alkylating immunomodulatory compound CTX, and selectively predicted longer progression-free survival in advanced lung and ovarian cancer patients treated with chemo-immunotherapy.
Journal ArticleDOI
Mitochondrial function controls intestinal epithelial stemness and proliferation
Emanuel Berger,Eva Rath,Detian Yuan,Nadine Waldschmitt,Sevana Khaloian,Michael Allgäuer,Ori Staszewski,Elena M. Lobner,Theresa Schöttl,Pieter Giesbertz,Olivia I. Coleman,Marco Prinz,Achim Weber,Markus Gerhard,Martin Klingenspor,Klaus-Peter Janssen,Mathias Heikenwalder,Dirk Haller +17 more
TL;DR: Compensatory hyperproliferation of HSP60+ escaper stem cells suggests paracrine release of WNT-related factors from H SP60-deficient, functionally impaired IEC to be pivotal in the control of the proliferative capacity of the stem cell niche.
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Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome.
Jonathan M. Pitt,Marie Vétizou,Marie Vétizou,Marie Vétizou,Nadine Waldschmitt,Guido Kroemer,Mathias Chamaillard,Ivo G. Boneca,Laurence Zitvogel +8 more
TL;DR: Findings that specific gut-resident bacteria determine the immunotherapeutic responses associated with CTLA-4 checkpoint blockade are presented, and how this new understanding could improve the therapeutic coverage of immune checkpoint inhibitors, and potentially limit their immune-mediated toxicity, through the use of adjunctive "oncomicrobiotics".
Journal ArticleDOI
Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence.
Sevana Khaloian,Eva Rath,Nassim Hammoudi,Elisabeth Gleisinger,Andreas Blutke,Pieter Giesbertz,Emanuel Berger,Amira Metwaly,Nadine Waldschmitt,Matthieu Allez,Dirk Haller +10 more
TL;DR: Evidence is provided that inflammation-associated mitochondrial dysfunction in the intestinal epithelium triggers a metabolic imbalance, causing reduced stemness and acquisition of a dysfunctional PC phenotype, and blocking glycolysis might be a novel drug target to antagonise PC dysfunction inThe pathogenesis of CD.