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Nagib Ali Elmarzugi

Bio: Nagib Ali Elmarzugi is an academic researcher from Universiti Teknologi Malaysia. The author has contributed to research in topics: Bioreactor & Amylase. The author has an hindex of 11, co-authored 36 publications receiving 458 citations.

Papers
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Journal ArticleDOI
TL;DR: In this paper, a review of the green synthesis of silver nanoparticles is presented, which showed more cost-effective and environmental friendly application as well as easier for large production, with relation to the properties of the nanoparticles as antimicrobial, can be served as an alternative antiseptic agent in various fields.
Abstract: In this century, the development of nanotechnology is projected to be the establishment of a technological evolutionary of this modern era. Recently, nanotechnology is one of the most active subjects of substantial research in modern material sciences and hence metal nanoparticles have a great scientific interest because of their unique optoelectronic and physicochemical properties with applications in diverse areas such as electronics, catalysis, drug delivery, or sensing. Nanotechnology provides an understanding on fundamental properties of objects at the atomic, molecular, and supramolecular levels. Besides, nanotechnology also leads an alternative technological pathway for the exploration and revolution of biological entities, whereas biology provides role models and biosynthetic constituents to nanotechnology. The findings of this review are important to provide an alternative for the green synthesis of silver nanoparticles. It showed more cost-effective and environmental friendly application as well as easier for large production, with relation to the properties of silver nanoparticles as antimicrobial, can be served well as an alternative antiseptic agent in various fields. Typically, silver nanoparticles are smaller than 100 nm and consist of about 20–15,000 silver atoms. Due to the attractive physical and chemical properties of silver at the nanoscale, the development of silver nanoparticles is expanding in recent years and is nowadays significant for consumer and medical products.

230 citations

Journal ArticleDOI
TL;DR: The aim of this article is to provide a detailed survey of the literature of cosmeceutical and external applications of N. sativa which is expected to stimulate further studies on this subject.
Abstract: It is estimated by the World Health Organization (WHO) that most of the world's population depends on herbal medicine for their health care. Nigella sativa (N. sativa), also known as black-caraway and as "Kalonji," is a well-known seed all over the world. It is one of the most common medicinal plants worldwide and contains many useful chemical constituents that we can find in its fixed oil, such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellimine, nigellicine, nigellidine, and alpha-hederin. Due to these numerous important ingredients it was found that it affects different areas of our body and has many pharmacological effects as antibacterial, antiviral, anti-inflammatory, and wound healing effect and also for acne vulgaris, skin cancer, pigmentation, and many cosmeceutical applications. Based on the folklore usage of N. sativa seeds and oil, they are used in various systems of food and medicines. The aim of this article is to provide a detailed survey of the literature of cosmeceutical and external applications of N. sativa which is expected to stimulate further studies on this subject.

42 citations

01 Jan 2015
TL;DR: Nanoemulsion is referred type of emulsion with uniform and extremely small droplet size in the range of 20-200 nm as mentioned in this paper, which provides numerous advantages over other carrier such as polymeric nanoparticle and liposomes, including low cost preparation procedure, high hydrophilic and lipophilic drug loading system to enhance the longer shelf live upon preserving the therapeutic agents.
Abstract: Nanoemulsion is referred type of emulsion with uniform and extremely small droplet size in the range of 20-200 nm. Nanoemulsion provides numerous advantages over other carrier such as polymeric nanoparticle and liposomes, including low cost preparation procedure, high hydrophilic and lipophilic drug loading system to enhance the longer shelf live upon preserving the therapeutic agents. Incorporating the preparation of nanoemulsion with hydrogel matrix to produce nanoemulgel exhibited by the two separate systems that forming it. Nanoemulgel possesses the properties of thixotropic, non-greasy, effortlessly spreadable, easily be removed, emollient, not staining, soluble in water, longer shelf life, bio-friendly, translucent and agreeable appearance. Keywords-Nanoemulsion, Nanoemulgel, Emulsifying method, Liposomes, Thixotropic, Hydrogel

37 citations

Journal ArticleDOI
TL;DR: In this paper, photocatalytic inorganic nanoparticles of ZnO have been employed for the purpose of long-term protection of exposed marble columns by inhibiting microbial-fungal attack and forming a protective surface layer.
Abstract: The marble columns at many historic sites represent one of the most important and fundamental architectural elements in a building. They are almost always subject to serious damage, whether in the base, middle, or crowns of columns by fungal infection. In most cases, the microbial deterioration affects the physical and mechanical properties of historic marble columns, which have in turn been affected by other damaging factors (e.g., weathering from the elements or mechanical damage), leading to their partial or total collapse. In this current study, researchers are turning to new technologies in order to find the ideal solution to inhibit fungal growth, and, in turn achieve the total protection of exposed historic marble columns. The photocatalytic inorganic nanoparticles of ZnO have been employed for the purpose of long-term protection of exposed marble columns by inhibiting microbial-fungal attack and forming a protective surface layer. ZnO nanoparticles were dispersed in laboratory synthesized acrylic polymer to create a combined biocidal and consolidating coating to be applied on historic marble columns substrate. The synthesized nanocomposite coating was characterized and applied to marble samples collected from various archeological sites in Egypt. The protecting effect of synthesized nanocoating against fungal attack by Aspergillus niger and Penicillium sp., in addition to RH/Temperature, UV aging, and mechanical deterioration, was studied. The consolidating action of the obtained mixtures was evaluated through microscopic examination and capillary water absorption. Further, colorimetric measurements have been performed to evaluate the optical appearance of the columns. ZnO nanocomposites displayed better performance when compared to the pure synthesized acrylic polymer. The coated ZnO nanoparticles enhanced the durability of stone surface to resist the fungal attack when subjected to inoculums containing Aspergillus niger and Penicillium sp. and improved the resistance to UV aging, relative humidity, and thermal effect compared to the samples coated with the acrylic polymer without ZnO nanoparticles. Self-protection properties were confirmed without any obvious color changes on marble surfaces.

30 citations

Journal ArticleDOI
TL;DR: The self-emulsifying systems developed for Swietenia oil in this study were constructed using ternary phase diagrams and contained the nonionic surfactants Labrasol, Tween 20, Capmul, and Labrafil, and the effect of these surfactant on the formulation was examined.
Abstract: There is an increasing trend among pharmaceutical industries to use natural bioactive materials as medicinal agents and to use new technologies such as self-nanoemulsifying systems. The solubility and bioavailability of poorly soluble drugs can be enhanced by self-nanoemulsifying systems. Swietenia oil is frequently used because of its antimicrobial, antimutagenic, and anticancer bioactive medical properties. This study was conducted to develop self-nanoemulsifying systems for Swietenia oil that will enhance the anti-inflammatory activity of the oil. The self-emulsifying systems developed for Swietenia oil in this study were constructed using ternary phase diagrams and contained the nonionic surfactants Labrasol®, Tween 20, Capmul®, and Labrafil®. The effect of these surfactants on the formulation was examined. The mean droplet size of Swietenia oil as well as their distribution, appearance, viscosity, and spreading times were studied to find the optimum formula, which contained droplets that were less than 200 nm. The next step was to test the anti-inflammatory properties of the optimum formula using a carrageenan-induced rat paw edema test. The results from this test were compared to the oil solution. Different oil/surfactants mixtures had various emulsification properties that were related to the size of their droplets. Tween 20 is a good surfactant to use in self-emulsifying systems because it produces droplets of nano-size. Mixtures of Capmul/Labrasol at a ratio of 2:1 and Labrafil/Tween 20 at a ratio of 1:2 were able to produce self-nanoemulsifying formulations containing Swietenia oil concentrations that ranged from 20%–50%. Nanoemulsion occurred when the size of the droplets fell below 200 nm with low size distribution (<0.3) after being gently mixed with water. It was found that the hydrophilic/lipophilic balance value affected the ternary phase diagram behavior of Swietenia oil and surfactants. In addition, the anti-inflammatory properties of Swietenia oil were greater in the self-nanoemulsifying systems than in the oil solution.

29 citations


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Journal ArticleDOI
TL;DR: The methods of making nanoparticles using plant extracts are reviewed, methods of particle characterization are reviewed and potential applications of the particles in medicine are discussed.

1,706 citations

Journal ArticleDOI
TL;DR: A state-of-the-art review on the synthesis of AgNPs, and their applications in antimicrobial textile fabrics, food packaging films, and wound dressings is provided.
Abstract: Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. They have been widely used as nanomaterials for manufacturing cosmetic and healthcare products, antimicrobial textiles, wound dressings, antitumor drug carriers, etc. due to their excellent antimicrobial properties. Accordingly, AgNPs have gained access into our daily life, and the inevitable human exposure to these nanoparticles has raised concerns about their potential hazards to the environment, health, and safety in recent years. From in vitro cell cultivation tests, AgNPs have been reported to be toxic to several human cell lines including human bronchial epithelial cells, human umbilical vein endothelial cells, red blood cells, human peripheral blood mononuclear cells, immortal human keratinocytes, liver cells, etc. AgNPs induce a dose-, size- and time-dependent cytotoxicity, particularly for those with sizes ≤10 nm. Furthermore, AgNPs can cross the brain blood barrier of mice through the circulation system on the basis of in vivo animal tests. AgNPs tend to accumulate in mice organs such as liver, spleen, kidney and brain following intravenous, intraperitoneal, and intratracheal routes of administration. In this respect, AgNPs are considered a double-edged sword that can eliminate microorganisms but induce cytotoxicity in mammalian cells. This article provides a state-of-the-art review on the synthesis of AgNPs, and their applications in antimicrobial textile fabrics, food packaging films, and wound dressings. Particular attention is paid to the bactericidal activity and cytotoxic effect in mammalian cells.

510 citations

Journal ArticleDOI
TL;DR: The present review highlights the antimicrobial effects of various nanomaterials and their potential advantages, drawbacks, or side effects and may be useful in the discovery of broad-spectrum antimicrobial drugs for use against multi-drug-resistant microbial pathogens in the near future.
Abstract: Antimicrobial substances may be synthetic, semisynthetic, or of natural origin (i.e., from plants and animals). Antimicrobials are considered “miracle drugs” and can determine if an infected patient/animal recovers or dies. However, the misuse of antimicrobials has led to the development of multi-drug-resistant bacteria, which is one of the greatest challenges for healthcare practitioners and is a significant global threat. The major concern with the development of antimicrobial resistance is the spread of resistant organisms. The replacement of conventional antimicrobials by new technology to counteract antimicrobial resistance is ongoing. Nanotechnology-driven innovations provide hope for patients and practitioners in overcoming the problem of drug resistance. Nanomaterials have tremendous potential in both the medical and veterinary fields. Several nanostructures comprising metallic particles have been developed to counteract microbial pathogens. The effectiveness of nanoparticles (NPs) depends on the interaction between the microorganism and the NPs. The development of effective nanomaterials requires in-depth knowledge of the physicochemical properties of NPs and the biological aspects of microorganisms. However, the risks associated with using NPs in healthcare need to be addressed. The present review highlights the antimicrobial effects of various nanomaterials and their potential advantages, drawbacks, or side effects. In addition, this comprehensive information may be useful in the discovery of broad-spectrum antimicrobial drugs for use against multi-drug-resistant microbial pathogens in the near future.

365 citations

Journal ArticleDOI
TL;DR: It is expected that metal-supported nanomaterials play an outstanding role not only in medical but also in other important areas such as antibacterial, antifungal, anticancer, and so on.
Abstract: Nanoparticles (nanoparticles) have received much attention in biological application because of their unique physicochemical properties. The metal- and metal oxide-supported nanomaterials have shown significant therapeutic effect in medical science. The mechanisms related to the interaction of nanoparticles with animal and plant cells can be used to establish its significant role and to improve their activity in health and medical applications. Various attempts have been made to discuss the antibiotic resistance and antimicrobial activity of metal-supported nanoparticles. Despite all these developments, there is still a need to investigate their performance to overcome modern challenges. In this regard, the present review examines the role of various types of metal-supported nanomaterials in different areas such as antibacterial, antifungal, anticancer, and so on. Based on the significant ongoing research and applications, it is expected that metal-supported nanomaterials play an outstanding role not only in medical but also in other important areas.

319 citations

01 Sep 2015
TL;DR: Subsequently, an agreement on technical co-operation between ISO and CEN was approved by the ISO Council resolution 18/1990 and the CEN General Assembly resolution 3/1990.
Abstract: Subsequently, an agreement on technical co-operation between ISO and CEN was approved by the ISO Council resolution 18/1990 and the CEN General Assembly resolution 3/1990. This agreement (called the Vienna Agreement) was published in June 1991. It is accompanied by common ISO-CEN “Guidelines for the TC/SC Chairmen and Secretariats for implementation”, approved in 1992 and revised in September 1998.

260 citations