Naibedya Chattopadhyay

TL;DR: It is demonstrated that RaKCaR protein is expressed in many different nephron segments and that the polarity of receptor expression varies with cell type along the nephrons, suggesting potential roles for the extracellular Ca2+/polyvalent cation-sensing receptor in responding to both circulating and urinary concentrations of divalent minerals and potentially other polyvalENT cations.

TL;DR: The data strongly suggest that the osteoblastic cell line MC3T3‐E1 possesses both CaR protein and mRNA very similar, if not identical, to those in parathyroid and kidney, and the CaR in these osteoblasts could play a key role in regulating bone turnover by stimulating the proliferation and migration of such cells to sites of bone resorption as a result of local release of Ca2+o.

TL;DR: IL-17 plays a critical causal role in Ovx-induced bone loss and may be considered a potential therapeutic target in pathogenesis of post menopausal osteoporosis.

TL;DR: The recent cloning of a [Ca2+]o-sensing receptor from several different tissues in several species directly demonstrates that a variety of cells can directly recognize and respond to small changes in their ambient level through a G protein-coupled, cell surface receptor.

TL;DR: Whether the MCF-7 and MDA-MB-231 human breast cancer cell lines express the CaR and whether CaR agonists modulate PTHrP secretion is investigated, which could potentially participate in a vicious cycle in which PTHRP-induced bone resorption raises the levels of Ca2+(o) and TGFbeta within the bony microenvironment, which then act in concert to evoke further P THrP release and worsening osteolysis.