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Najihah Mohd Hashim
Researcher at University of Malaya
Publications - 87
Citations - 1645
Najihah Mohd Hashim is an academic researcher from University of Malaya. The author has contributed to research in topics: Apoptosis & Cell cycle. The author has an hindex of 19, co-authored 81 publications receiving 1233 citations. Previous affiliations of Najihah Mohd Hashim include Universiti Teknologi MARA & Universiti Putra Malaysia.
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Journal ArticleDOI
α-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties
Mohamed Yousif Ibrahim,Najihah Mohd Hashim,Abdalbasit Adam Mariod,Syam Mohan,Mahmood Ameen Abdulla,Siddig Ibrahim Abdelwahab,Ismail Adam Arbab +6 more
TL;DR: The present work reviews recent studies on the central and potential pharmacological principles as well as the preclinical applications of the α -mangostin.
Journal ArticleDOI
Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A.
Syam Mohan,Siddig Ibrahim Abdelwahab,Siddig Ibrahim Abdelwahab,Behnam Kamalidehghan,Suvitha Syam,Koh Sue May,Nabil S. Harmal,Noor Shafifiyaz,A. Hamid A. Hadi,Najihah Mohd Hashim,Mawardi Rahmani,Manal Mohamed Elhassan Taha,Shiau-Chuen Cheah,Asdren Zajmi +13 more
TL;DR: The results showed that PA possesses the characteristics of selectively inducing cell death of tumor cells as no inhibition was observed in non-tumorigenic cells even at 30 μg/ml.
Journal ArticleDOI
Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith
Heyam Mohamed Ali Sidahmed,Najihah Mohd Hashim,Mahmood Ameen Abdulla,Hapipah Mohd Ali,Syam Mohan,Siddig Ibrahim Abdelwahab,Manal Mohamed Elhassan Taha,Loke Mun Fai,Jamuna Vadivelu +8 more
TL;DR: It is revealed that zerumbone promotes ulcer protection, which might be attributed to the maintenance of mucus integrity, antioxidant activity, and HSP-70 induction.
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Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide, and anti-Helicobacter pylori activity.
Heyam Mohamed Ali Sidahmed,Ainnul Hamidah Syahadah Azizan,Syam Mohan,Mahmood Ameen Abdulla,Siddig Ibrahim Abdelwahab,Manal Mohamed Elhassan Taha,A. Hamid A. Hadi,Kamal Aziz Ketuly,Najihah Mohd Hashim,Mun Fai Loke,Jamuna Vadivelu +10 more
TL;DR: The current study reveals that DES demonstrated gastroprotective effects which could be attributed to its antioxidant effect, activation of HSP-70 protein, intervention with COX-2 inflammatory pathway and potent anti H pylori effect.
Journal ArticleDOI
Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo
Heyam Mohamed Ali Sidahmed,Najihah Mohd Hashim,Junaidah Amir,Mahmood Ameen Abdulla,A. Hamid A. Hadi,Siddig Ibrahim Abdelwahab,Manal Mohamed Elhassan Taha,Pouya Hassandarvish,Xinsheng Teh,Mun Fai Loke,Jamuna Vadivelu,Mawardi Rahmani,Syam Mohan +12 more
TL;DR: The results of the present study indicate that the gastroprotective effect of PA might contribute to the antioxidant and anti-inflammatory properties as well as the anti-apoptotic mechanism and antibacterial action against Helicobacter pylori.