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Author

Nakayama Yasuhide

Other affiliations: Bridgestone
Bio: Nakayama Yasuhide is an academic researcher from Osaka University. The author has contributed to research in topics: Transfer agent & Polymer. The author has an hindex of 7, co-authored 94 publications receiving 403 citations. Previous affiliations of Nakayama Yasuhide include Bridgestone.


Papers
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Patent
20 Aug 2003
TL;DR: In this paper, a flexible polymer layer is used to cover the entire surface of the stent matrix, and the polymer layer can be attached to and covered by a tubular stent.
Abstract: A stent comprising a tubular stent matrix of which diameter is extendable and a flexible polymer layer covering the stent matrix. The polymer layer is closely attached to and covers the entire surface of the stent matrix. Since the flexible polymer layer closely covers the entire surface of the stent matrix not only the outer periphery of the stent matrix, the stent has no problem of causing allergic to metal, stimulus of tissues due to metal, and rust development. Since the inner periphery of the stent is a flat and smooth surface covered by the polymer layer without convexes and concaves, the formation of thrombus can be inhibited well. There is no problem of drift between the polymer layer and the stent matrix, thereby maintaining the positional relationship between the stent matrix and the polymer layer before and after the expansion of the stent.

119 citations

Journal ArticleDOI
TL;DR: Gene delivery to endothelial cells was significantly enhanced by only the addition of RGD peptides to star vector-based polyplexes and exhibited minimal cellular cytotoxicity.

34 citations

Patent
23 May 2006
TL;DR: In this paper, an outer hull member 2 is formed on the surface of a rod-like structure member 1 to form the base material for forming the connective tissue, which is then used to construct an artificial organ.
Abstract: PROBLEM TO BE SOLVED: To provide an artificial organ utilizing tissue formed on the surface of an artificial object embedded in a living body which keeps the formed connective tissue highly independent, anastomosable, and antithrombogenicity. SOLUTION: An outer hull member 2 is formed on the surface of a rodlike structure member 1 to form the base material for forming the connective tissue. By embedding the base material in the living body, a filmy tissue is formed on the surface of the base material. At that time, by utilizing a material which is excellent in biocompatibility but is hardly invaded by a tissue body or a constituting component thereof as a material of the outer hull member 2, the outer hull member 2 is adhered with the tissue, the mechanical strength of the connective tissue is enhanced, and an artificial blood vessel in which the tissue or the constituent component thereof is not exposed to the inner face of the outer hull member 2 can be obtained. COPYRIGHT: (C)2010,JPO&INPIT

15 citations

Patent
25 Feb 2008
TL;DR: In this paper, a profile member 2 is spirally formed along the outer periphery of a rodlike structural member 1 by embedding the profile member in the living body, and the connective tissue 4 is formed on the external edge of the rod-like structural members 1.
Abstract: PROBLEM TO BE SOLVED: To provide a connective tissue forming base material for forming a connective tissue which is utilized as an artificial organ when being embedded in a living body, and which can smooth the internal surface while increasing the mechanical strength or the like of the connective tissue. SOLUTION: A profile member 2 is spirally formed along the outer periphery of a rodlike structural member 1. By embedding the rodlike structural member 1 in the living body, the connective tissue 4 is formed on the external edge of the rodlike structural member 1. The connective tissue 4 enters a gap between the profile member 2 and the surface of the rodlike structural member 1. The internal surface shape of the connective tissue 4 is formed into a smooth surface being the same as the surface of the rodlike structural member 1. The connective tissue 4 is formed to have a thickness for embedding the profile member 2. COPYRIGHT: (C)2009,JPO&INPIT

15 citations

Journal ArticleDOI
TL;DR: SV was a potential carrier for siRNA and shRNA delivery in both in vitro and in vivo conditions, and this finding suggests that it may offer a new clinical therapeutic approach in gene therapy.

11 citations


Cited by
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Patent
10 Aug 2016
TL;DR: In this article, a staple assembly including staples is described, which includes features which improve the biocompatibility and/or bioabsorption of the staples, such as magnesium alloy, zinc, and metal-oxide.
Abstract: A staple cartridge assembly including staples is disclosed herein. The staples comprise features which improve the biocompatibility and/or bioabsorption of the staples. The staples are comprised of a magnesium alloy, for example. The magnesium alloy can also include zinc. In certain instances, a bioabsorbable polymer is coated on part of, but not all of, the staple. Portions of the staple that are not coated by the bioabsorbable polymer will be absorbed at a first rate while portions of the staple that are coated by the bioabsorbable polymer will be absorbed at a slower rate. In various instances, the tips of the magnesium staples are coated with magnesium nitride and/or any other suitable material which can increase the hardness of the staples. In certain instances, the staples are coated in silver. In some instances, the staples include one or more apertures defined therein.

328 citations

Journal ArticleDOI
TL;DR: This review outlines the advances in the use of star polymers in biomedical applications during the past decade, especially highlighting the general design requirements in relation to biomedical performance.

302 citations

Journal ArticleDOI
TL;DR: This article will first give a brief overview of the physical and biological properties of chitosan, then, with a special focus on plasmid DNA delivery, a detailed discussion of the latest advances in chitOSan-mediated NA transfer.

233 citations

Journal ArticleDOI
Jianan Shen1, Qi Yin1, Lingli Chen1, Zhiwen Zhang1, Yaping Li1 
TL;DR: The in vivo antitumor efficacy showed that PTPNs were more effective than that of the Taxol, and the co-delivery of PTX and shSur by P TPNs could be a very powerful approach to improve the therapeutic effect ofPTX in resistant lung cancer.

131 citations

Journal ArticleDOI
26 Oct 2010-ACS Nano
TL;DR: A rapid developmental pathway toward highly efficient gene delivery systems is demonstrated by leveraging the powers of a supramolecular synthetic approach and a custom-designed digital microreactor for generating nanoparticle-based vectors for delivery of a variety of loads.
Abstract: Nanoparticles are regarded as promising transfection reagents for effective and safe delivery of nucleic acids into a specific type of cells or tissues providing an alternative manipulation/therapy strategy to viral gene delivery. However, the current process of searching novel delivery materials is limited due to conventional low-throughput and time-consuming multistep synthetic approaches. Additionally, conventional approaches are frequently accompanied with unpredictability and continual optimization refinements, impeding flexible generation of material diversity creating a major obstacle to achieving high transfection performance. Here we have demonstrated a rapid developmental pathway toward highly efficient gene delivery systems by leveraging the powers of a supramolecular synthetic approach and a custom-designed digital microreactor. Using the digital microreactor, broad structural/functional diversity can be programmed into a library of DNA-encapsulated supramolecular nanoparticles (DNA⊂SNPs) by systematically altering the mixing ratios of molecular building blocks and a DNA plasmid. In vitro transfection studies with DNA⊂SNPs library identified the DNA⊂SNPs with the highest gene transfection efficiency, which can be attributed to cooperative effects of structures and surface chemistry of DNA⊂SNPs. We envision such a rapid developmental pathway can be adopted for generating nanoparticle-based vectors for delivery of a variety of loads.

123 citations