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Namho Kim
Researcher at Johns Hopkins University School of Medicine
Publications - 21
Citations - 3171
Namho Kim is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Gene delivery & In vivo. The author has an hindex of 12, co-authored 20 publications receiving 2111 citations. Previous affiliations of Namho Kim include Purdue University & Lehigh University.
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Journal ArticleDOI
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
TL;DR: The history of the development of PEGylated nanoparticle formulations for systemic administration is described, including how factors such as PEG molecular weight, PEG surface density, nanoparticle core properties, and repeated administration impact circulation time.
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PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy.
Gizem Osman,Jason Rodriguez,Sze Yan Chan,Jane Chisholm,Gregg A. Duncan,Namho Kim,Amanda L. Tatler,Kevin M. Shakesheff,Justin Hanes,Jung Soo Suk,Jung Soo Suk,James E. Dixon +11 more
TL;DR: An innovative approach that combines novel GET peptides for enhanced transfection with a tuneable PEG coating for efficacious lung gene therapy is described.
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Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model
Brian P. Mead,Namho Kim,G. Wilson Miller,David Hodges,Panagiotis Mastorakos,Alexander L. Klibanov,James Mandell,Jay Hirsh,Jung Soo Suk,Justin Hanes,Richard J. Price +10 more
TL;DR: A two-pronged treatment strategy, composed of MR image-guided focused ultrasound (FUS) and brain-penetrating nanoparticles (BPN), that provides widespread but targeted GDNF transgene expression in the brain following systemic administration, thereby potentially providing a novel means to treat Parkinson's disease.
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Barriers to inhaled gene therapy of obstructive lung diseases: A review
TL;DR: Key components for successful execution of inhaled gene therapy, including gene delivery systems, primary physiological barriers and strategies to overcome them, and advances in preclinical disease models with which the most promising systems may be identified for human clinical trials are reviewed.
Journal ArticleDOI
Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection
Colleen T. Curley,Brian P. Mead,Karina Negron,Namho Kim,Namho Kim,William J. Garrison,G. Wilson Miller,Kathryn M. Kingsmore,E. Andrew Thim,Ji Song,Jennifer M. Munson,Alexander L. Klibanov,Jung Soo Suk,Justin Hanes,Justin Hanes,Richard J. Price +15 more
TL;DR: It is concluded that FUS-mediated BTB/BBB opening yields markedly augmented interstitial tumor flow that, in turn, plays a critical role in enhancing BPN transport through tumor tissue.