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Nan Zhou

Bio: Nan Zhou is an academic researcher from Beijing University of Chemical Technology. The author has contributed to research in topics: Ultimate tensile strength & Composite material. The author has an hindex of 2, co-authored 3 publications receiving 7 citations.

Papers
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TL;DR: In this article, the peptide motif design, self-assembly synthesis, and functional tailoring of peptide nano-assemblies for both cancer diagnosis and therapy are summarized. And the challenges and perspectives in this promising topic are discussed.
Abstract: Peptide molecule has high bioactivity, good biocompatibility, and excellent biodegradability. In addition, it has adjustable amino acid structure and sequence, which can be flexible designed and tailored to form supramolecular nano-assemblies with specific biomimicking, recognition, and targeting properties via molecular self-assembly. These unique properties of peptide nano-assemblies made it possible for utilizing them for biomedical and tissue engineering applications. In this review, we summarize recent progress on the motif design, self-assembly synthesis, and functional tailoring of peptide nano-assemblies for both cancer diagnosis and therapy. For this aim, firstly we demonstrate the methodologies on the synthesis of various functional pure and hybrid peptide nano-assemblies, by which the structural and functional tailoring of peptide nano-assemblies are introduced and discussed in detail. Secondly, we present the applications of peptide nano-assemblies for cancer diagnosis applications, including optical and magnetic imaging as well as biosensing of cancer cells. Thirdly, the design of peptide nano-assemblies for enzyme-mediated killing, chemo-therapy, photothermal therapy, and multi-therapy of cancer cells are introduced. Finally, the challenges and perspectives in this promising topic are discussed. This work will be useful for readers to understand the methodologies on peptide design and functional tailoring for highly effective, specific, and targeted diagnosis and therapy of cancers, and at the same time it will promote the development of cancer diagnosis and therapy by linking those knowledges in biological science, nanotechnology, biomedicine, tissue engineering, and analytical science.

23 citations

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TL;DR: Recent advance in the fabrication of flexible sensors by using functional nanomaterials including nanoparticles, carbon materials, metal‐organic materials, and polymers is presented and the potential biomedical applications of the fabricated flexible sensors for detecting gas molecules signals, small molecules, DNA/RNA, proteins, others are introduced and discussed.
Abstract: The fabrication of flexible sensors is a potential way to promote the progress of modern social science and technology due to their wide applications in high-performance electronic equipment and devices. Flexible sensors based on organic materials combine the unique advantages of flexibility and low cost, increasing interest in healthcare monitoring, treatment, and human-machine interfaces. Advances in materials science and biotechnology have rapidly accelerated the development of bio-integrated multifunctional sensors and devices. Due to their excellent mechanical and electrical properties, many types of functional materials provided benefits for the construction of various sensors with improved flexibility and stretchability. In this review, recent advance in the fabrication of flexible sensors by using functional nanomaterials including nanoparticles, carbon materials, metal-organic materials, and polymers is presented. In addition, the potential biomedical applications of the fabricated flexible sensors for detecting gas molecules signals, small molecules, DNA/RNA, proteins, others are introduced and discussed.

22 citations

Journal ArticleDOI
TL;DR: In this paper , two hemispherical impactors with different diameters were used to preload different energies to impact the node position and base position of the sandwich panel, respectively, revealing the failure mechanism, response characteristics, and the influence of various variables on the impact resistance of the structure.
Abstract: To study the impact resistance of the S-shaped carbon-fiber foldcore sandwich structure, the S-shaped foldcore was prepared by the hot press molding process, and then the S-shaped carbon-fiber foldcore sandwich structure was designed by face-to-core bonding and curing through a secondary bonding process. Two hemispherical impactors with different diameters were used to preload different energies to impact the node position and base position of the sandwich panel, respectively, revealing the failure mechanism, response characteristics of the sandwich panel, and the influence of various variables on the impact resistance of the structure. The research shows that the panel of S-shaped foldcore sandwich structure has tensile fracture failure. The core is affected by the structural characteristics and load-bearing forms, and there are mainly two failure modes of brittle crushing fracture and tensile fracture. The load–displacement curve shows that the relative size of the impactor and the unit cell of the core has a significant influence on the impact damage behavior. The sandwich panel has better impact resistance for the impactor with diameter greater than the cell span, and the difference between different impact positions is reduced. In application, the span of the core cell can be reduced to further improve the protective effect of the structure. The sandwich structure studied in this paper is lightweight and has good impact resistance, which can be used in the field of lightweight protection in the future. • A new type of S-shaped foldcore was prepared by hot pressing. • The dynamic response and damage mode of the structure under low-velocity impact are studied. • The core damage mode is determined by the structural characteristics and load-bearing form. • The sandwich panel has better impact resistance for impactors whose size is larger than the unit cell span.

9 citations

Journal ArticleDOI
TL;DR: In this article, the Co3O4/NiCo2O4 nanocomposite has been prepared as a novel electrochemical sensor to accurately detect hydrogen peroxide (H2O2) and glucose.

8 citations

Journal ArticleDOI
TL;DR: In this article , the S-shaped glass fiber composite foldcore sandwich structure was fabricated by hot pressing method and its impact resistance against the aluminum foam projectiles was studied using a one-stage gas gun.
Abstract: S-shaped foldcore sandwich structures have potential applications as protection structures under impact loading. In this paper, the S-shaped glass fiber composite foldcore sandwich structure was fabricated by hot pressing method and its impact resistance against the aluminum foam projectiles was studied using a one-stage gas gun. The three-dimensional digital image correlation system was used to measure the dynamic deformation of the sandwich panels. During the experiments, the dynamic response of the structure was studied when the projectile impacted the node and base locations of the sandwich structure, where the node location refers to the top platform of the core and the base location refers to the middle position between the nodes. In addition, the influence of the face sheet thickness and core thickness on the impact resistance of the sandwich structure was also investigated. The results show that the sandwich structure is dominated by tensile fracture of the face sheet, crush fracture or extrusion fracture of the core, and debonding failure between the face sheet and the core. The impact resistance of the node location is better than that of the base location for the same configuration. Moreover, the maximum deflection of the rear sheet increases linearly with the increase of the impact loading when impacting the base location. And increasing the face sheet thickness or core thickness can better reduce the structure deflection and improve the impact resistance of the structure.

5 citations


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TL;DR: In this article, a comprehensive review has been made to cover recent developments in the field of carbon-based nanomaterials for sensing applications, including fullerenes, carbon onions, carbon quantum dots, nanodiamonds, carbon nanotubes, and graphene.
Abstract: Recent advances in nanomaterial design and synthesis has resulted in robust sensing systems that display superior analytical performance. The use of nanomaterials within sensors has accelerated new routes and opportunities for the detection of analytes or target molecules. Among others, carbon-based sensors have reported biocompatibility, better sensitivity, better selectivity and lower limits of detection to reveal a wide range of organic and inorganic molecules. Carbon nanomaterials are among the most extensively studied materials because of their unique properties spanning from the high specific surface area, high carrier mobility, high electrical conductivity, flexibility, and optical transparency fostering their use in sensing applications. In this paper, a comprehensive review has been made to cover recent developments in the field of carbon-based nanomaterials for sensing applications. The review describes nanomaterials like fullerenes, carbon onions, carbon quantum dots, nanodiamonds, carbon nanotubes, and graphene. Synthesis of these nanostructures has been discussed along with their functionalization methods. The recent application of all these nanomaterials in sensing applications has been highlighted for the principal applicative field and the future prospects and possibilities have been outlined.

70 citations

Journal ArticleDOI
TL;DR: In this article, the latest progresses in flexible pressure sensors based on metal and carbonaceous nanomaterials are reviewed and classified by different transduction principles, evaluation parameters and nano-micro structures.

60 citations

Journal ArticleDOI
TL;DR: In this article , the advantages and disadvantages of various flexible substrates that have been utilized for the design of H2O2 sensors were discussed, and future perspectives on how to address some of the substrate limitations and examples of application-driven sensors are also discussed.
Abstract: Hydrogen peroxide (H2O2) is a common chemical used in many industries and can be found in various biological environments, water, and air. Yet, H2O2 in a certain range of concentrations can be hazardous and toxic. Therefore, it is crucial to determine its concentration at different conditions for safety and diagnostic purposes. This review provides an insight about different types of sensors that have been developed for detection of H2O2. Their flexibility, stability, cost, detection limit, manufacturing, and challenges in their applications have been compared. More specifically the advantages and disadvantages of various flexible substrates that have been utilized for the design of H2O2 sensors were discussed. These substrates include carbonaceous substrates (e.g., reduced graphene oxide films, carbon cloth, carbon, and graphene fibers), polymeric substrates, paper, thin glass, and silicon wafers. Many of these substrates are often decorated with nanostructures composed of Pt, Au, Ag, MnO2, Fe3O4, or a conductive polymer to enhance the performance of sensors. The impact of these nanostructures on the sensing performance of resulting flexible H2O2 sensors has been reviewed in detail. In summary, the detection limits of these sensors are within the range of 100 nM–1 mM, which makes them potentially, but not necessarily, suitable for applications in health, food, and environmental monitoring. However, the required sample volume, cost, ease of manufacturing, and stability are often neglected compared to other detection parameters, which hinders sensors’ real-world application. Future perspectives on how to address some of the substrate limitations and examples of application-driven sensors are also discussed.

20 citations

Journal ArticleDOI
TL;DR: A review of peptide-based biosensors for precise detection, especially on tumor-related analysis, is provided in this paper, where a brief overview of the progress in tumor immune-related detection is provided.
Abstract: Small-molecular targeting peptides possess features of biocompatibility, affinity, and specificity, which is widely applied in molecular recognition and detection. Moreover, peptides can be developed into highly ordered supramolecular assemblies with boosting binding affinities, diverse functions, and enhanced stabilities suitable for biosensors construction. In this Review, we summarize recent progress of peptide-based biosensors for precise detection, especially on tumor-related analysis, as well as further provide a brief overview of the progress in tumor immune-related detection. Also, we are looking forward to the prospective future of peptide-based biosensors.

16 citations