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Nancy D. Dalton
Researcher at University of California, San Diego
Publications - 119
Citations - 12926
Nancy D. Dalton is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Heart failure & Cardiomyopathy. The author has an hindex of 51, co-authored 115 publications receiving 11733 citations. Previous affiliations of Nancy D. Dalton include Kyungpook National University & University of California, Los Angeles.
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Journal ArticleDOI
MicroRNA-133 controls cardiac hypertrophy
Alessandra Carè,Daniele Catalucci,Federica Felicetti,Désirée Bonci,Antonio Addario,Paolo Gallo,Marie Louise Bang,Patrizia Segnalini,Yusu Gu,Nancy D. Dalton,Leonardo Elia,Michael V.G. Latronico,Morten A. Høydal,Camillo Autore,Matteo Antonio Russo,Gerald W. Dorn,Øyvind Ellingsen,Pilar Ruiz-Lozano,Kirk L. Peterson,Carlo M. Croce,Cesare Peschle,Gianluigi Condorelli +21 more
TL;DR: The data show thatmiR-133, and possibly miR-1, are key regulators of cardiac hypertrophy, suggesting their therapeutic application in heart disease.
Journal ArticleDOI
Fibulin-5/DANCE is essential for elastogenesis in vivo
Tomoyuki Nakamura,Pilar Ruiz Lozano,Yasuhiro Ikeda,Yoshitaka Iwanaga,Aleksander Hinek,Susumu Minamisawa,Ching-Feng Cheng,Kazuhiro Kobuke,Nancy D. Dalton,Yoshikazu Takada,Kei Tashiro,John Ross,Tasuku Honjo,Kenneth R. Chien +13 more
TL;DR: It is reported that fibulin-5 (also known as DANCE), a recently discovered integrin ligand, is an essential determinant of elastic fibre organization and may provide anchorage of elastic fibres to cells, thereby acting to stabilize and organize elastic fibre in the skin, lung and vasculature.
Journal ArticleDOI
The δC Isoform of CaMKII Is Activated in Cardiac Hypertrophy and Induces Dilated Cardiomyopathy and Heart Failure
Tong Zhang,Lars S. Maier,Lars S. Maier,Nancy D. Dalton,Shigeki Miyamoto,John Ross,Donald M. Bers,Joan Heller Brown +7 more
TL;DR: It is demonstrated that expression of the &dgr;C isoform of CaMKII is selectively increased and its phosphorylation elevated as early as 2 days and continuously for up to 7 days after pressure overload, and this findings are the first to demonstrate that Ca MKII&d Gr;C can mediate phosphorylated of Ca2+ regulatory proteins in vivo.
Journal ArticleDOI
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.
Gianluigi Condorelli,Alessandra Drusco,Giorgio Stassi,Alfonso Bellacosa,Roberta Roncarati,Guido Iaccarino,Matteo Antonio Russo,Yusu Gu,Nancy D. Dalton,Clarence Chung,Michael V.G. Latronico,Claudio Napoli,Junichi Sadoshima,Carlo M. Croce,John Ross +14 more
TL;DR: It is found that Akt overexpression produced cardiac hypertrophy at the molecular and histological levels, with a significant increase in cardiomyocyte cell size and concentric LVHypertrophy in vivo by activating the glycogen synthase kinase3-β/GATA 4 pathway.
Journal ArticleDOI
Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis
Thomas Moore-Morris,Nuno Guimarães-Camboa,Indroneal Banerjee,Alexander C. Zambon,Tatiana Kisseleva,Aurélie Velayoudon,William B. Stallcup,Yusu Gu,Nancy D. Dalton,Marta Cedenilla,Rafael L. Gomez-Amaro,Bin Zhou,David A. Brenner,Kirk L. Peterson,Ju Chen,Sylvia M. Evans +15 more
TL;DR: Following pressure overload, fibroblasts were not derived from hematopoietic cells, EndoMT, or epicardial epithelial-to-mesenchymal transition; instead, pressure overload promoted comparable proliferation and activation of two resident fibroblast lineages, including a previously described epicardsial population and a population of endothelial origin.