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Nancy E. Hynes
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 179
Citations - 26598
Nancy E. Hynes is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Receptor tyrosine kinase & ErbB. The author has an hindex of 71, co-authored 177 publications receiving 25525 citations. Previous affiliations of Nancy E. Hynes include Novartis & University of Basel.
Papers
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Journal ArticleDOI
ERBB receptors and cancer: the complexity of targeted inhibitors.
Nancy E. Hynes,Heidi Lane +1 more
TL;DR: This work discusses the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response, and many ERBB inhibitors used in the clinic.
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The ErbB signaling network: receptor heterodimerization in development and cancer
TL;DR: The role of ErbB receptors as normal signal transducers and their contribution to the process of malignant transformation during tumor development are concentrated on.
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ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
TL;DR: Analysis of ErbB receptor interplay induced by the epidermal growth factor (EGF)‐related peptides provides the first biochemical evidence that a given Erb B receptor has distinct signaling properties depending on its dimerization.
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Correction: ERBB Receptors and Cancer: The Complexity of Targeted Inhibitors
Nancy E. Hynes,Heidi Lane +1 more
TL;DR: The authors would like to correct Figure 4b of this article, which reads “The epidermal growth factor receptor variant III (EGFRvarIII) cannot bind cetuximab or matuzumab”.
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The biology of erbB-2/neu/HER-2 and its role in cancer.
Nancy E. Hynes,David F. Stern +1 more