Nancy V. Brown

TL;DR: Factors that contribute to the immunogenicity of these highly targeted and relatively conserved sequences in HIV that may represent promising vaccine candidates for ethnically heterogeneous populations are identified.

TL;DR: This report is the first to demonstrate the safety of a recombinant DEN virus tetravalent vaccine in a formal neurovirulence test, as well as its protective efficacy in a monkey challenge model.

TL;DR: It is demonstrated that de novo responses against escape variants of CD8+ T-cell epitopes can be generated in chronic HIV-1 infection and provides the rationale for developing vaccines to induce CD8- T- cell responses directed against both the wild-type and variant forms ofCD8 epitopes to prevent the emergence of cytotoxic T-lymphocyte escape variants.

TL;DR: Functional assays confirmed the frequent recognition of HLA class I‐restricted T cell epitopes on several alternative alleles across HLAclass I supertypes and encoded on different class I loci, suggesting promiscuous binding of T helper epitopes to MHC class II molecules.

TL;DR: It is concluded that infection with hepatitis B virus undetectable by conventional assays and with hepatitis C virus may represent important unrecognized causes of idiopathic chronic liver disease in Israel.