Author
Nanjangud V. Anil Kumar
Other affiliations: Manipal Institute of Technology
Bio: Nanjangud V. Anil Kumar is an academic researcher from Manipal University. The author has contributed to research in topics: Biotechnology & Nanoparticle. The author has an hindex of 10, co-authored 14 publications receiving 661 citations. Previous affiliations of Nanjangud V. Anil Kumar include Manipal Institute of Technology.
Topics: Biotechnology, Nanoparticle, Nutraceutical, Phytochemical, Conjugate
Papers
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Kerman Medical University1, Manipal University2, University of Cagliari3, University of Salento4, University of Belgrade5, University of Bamenda6, Canadian Real Estate Association7, Central University, India8, Holy Spirit University of Kaslik9, University of Porto10, University of Concepción11, University of Medicine and Pharmacy of Craiova12, University of Alabama in Huntsville13, Hospital Authority14, Shahid Beheshti University of Medical Sciences and Health Services15
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
Abstract: Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.
619 citations
University of Winnipeg1, Manipal Institute of Technology2, Tajik State Medical University3, University of Concepción4, Andrés Bello National University5, Shahid Beheshti University of Medical Sciences and Health Services6, University of Yaoundé7, Universiti Teknologi MARA8, Universiti Putra Malaysia9, University of Milan10, University of Alabama in Huntsville11, Canadian Real Estate Association12, University of Naples Federico II13, Kendall College of Art and Design14, University of Karachi15, Jiroft University16
TL;DR: Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies.
Abstract: Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.
299 citations
TL;DR: Clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are presented and discussed.
291 citations
Shahid Beheshti University of Medical Sciences and Health Services1, Manipal Institute of Technology2, Gazi University3, Zabol University of Medical Sciences4, University of Illinois at Urbana–Champaign5, University of Novi Sad6, University of Milan7, University of Alabama in Huntsville8, University of Winnipeg9
TL;DR: A survey of plants that have shown anti-HIV activity, both in vitro and in vivo is presented, to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies.
Abstract: Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.
106 citations
Canadian Real Estate Association1, University of Cagliari2, University of Milan3, Manipal Institute of Technology4, University of Salento5, University of Belgrade6, University of Yaoundé I7, Hemwati Nandan Bahuguna Garhwal University8, Holy Spirit University of Kaslik9, University of Alabama in Huntsville10, University of Bologna11, University of the Balearic Islands12, University of Concepción13, University of Porto14, Kerman Medical University15, Shahid Beheshti University of Medical Sciences and Health Services16
TL;DR: The role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion.
Abstract: Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented.
91 citations
Cited by
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Journal Article•
TL;DR: Male circumcision significantly reduces the risk of HIV acquisition in young men in Africa and should be integrated with other HIV preventive interventions and provided as expeditiously as possible.
1,692 citations
Kerman Medical University1, Manipal University2, University of Cagliari3, University of Salento4, University of Belgrade5, University of Bamenda6, Canadian Real Estate Association7, Central University, India8, Holy Spirit University of Kaslik9, University of Porto10, University of Concepción11, University of Medicine and Pharmacy of Craiova12, University of Alabama in Huntsville13, Hospital Authority14, Shahid Beheshti University of Medical Sciences and Health Services15
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
Abstract: Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.
619 citations
15 Jul 2005
TL;DR: The scope of work of each of the FDA's major components is described, and the role of statisticians at FDA is addressed.
Abstract: The Food and Drug Administration (FDA) is a regulatory agency of the United States federal government This article describes the scope of work of each of the FDA's major components, and addresses the role of statisticians at FDA
Keywords:
drug regulation;
clinical trials;
medical devices;
safety;
bioassay
579 citations
University of Winnipeg1, Manipal Institute of Technology2, Tajik State Medical University3, University of Concepción4, Andrés Bello National University5, Shahid Beheshti University of Medical Sciences and Health Services6, University of Yaoundé7, Universiti Teknologi MARA8, Universiti Putra Malaysia9, University of Milan10, University of Alabama in Huntsville11, Canadian Real Estate Association12, University of Naples Federico II13, Kendall College of Art and Design14, University of Karachi15, Jiroft University16
TL;DR: Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies.
Abstract: Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.
299 citations
TL;DR: Several strategies such as inhibition of curcumin metabolism with adjuvants as well as novel solid and liquid oral delivery systems have been tried to counteractCurcumin poor absorption and rapid elimination from the body.
Abstract: The yellow pigment curcumin, extracted from turmeric, is a renowned polyphenol with a broad spectrum of health properties such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, hepatoprotective, anti-allergic, anti-dermatophyte, and neuroprotective. However, these properties are followed by a poor pharmacokinetic profile which compromises its therapeutic potential. The association of low absorption by the small intestine and the extensive reductive and conjugative metabolism in the liver dramatically weakens the oral bioavailability. Several strategies such as inhibition of curcumin metabolism with adjuvants as well as novel solid and liquid oral delivery systems have been tried to counteract curcumin poor absorption and rapid elimination from the body. Some of these drug deliveries can successfully enhance the solubility, extending the residence in plasma, improving the pharmacokinetic profile and the cellular uptake.
254 citations