N
Naoto Itoh
Researcher at Osaka University
Publications - 56
Citations - 10568
Naoto Itoh is an academic researcher from Osaka University. The author has contributed to research in topics: Insulitis & Antigen. The author has an hindex of 32, co-authored 56 publications receiving 10453 citations. Previous affiliations of Naoto Itoh include Osaka Bioscience Institute & Setsunan University.
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Journal ArticleDOI
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
Naoto Itoh,Shin Yonehara,Ai Ishii,Minako Yonehara,Sei Ichi Mizushima,Masazumi Sameshima,Atsushi Hase,Yoshiyuki Seto,Shigekazu Nagata +8 more
TL;DR: Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells and revealed that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide with a single transmembrane domain.
Journal ArticleDOI
Lethal effect of the anti-Fas antibody in mice
Jun Ogasawara,Rie Watanabe-Fukunaga,Masashi Adachi,Akio Matsuzawa,Tsutomu Kasugai,Yukihiko Kitamura,Naoto Itoh,Takashi Suda,Shigekazu Nagata +8 more
TL;DR: The findings suggest that the Fas antigen is important in programmed cell death in the liver, and may be involved in fulminant hepatitis in some cases.
Journal ArticleDOI
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen.
Naoto Itoh,Shigekazu Nagata +1 more
TL;DR: A 68-amino acid portion of the signal-transducing domain significantly conserved in the Fas antigen as well as in the type I tumor necrosis factor receptor was considered to be the novel protein domain required for apoptotic signal transduction.
Journal Article
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.
Rie Watanabe-Fukunaga,Camilynn I. Brannan,Naoto Itoh,Shin Yonehara,Neal G. Copeland,Nancy A. Jenkins,Shigekazu Nagata +6 more
TL;DR: Interspecific backcross analysis indicated that the gene coding for the Fas antigen is in the distal region of mouse chromosome 19, and was significantly induced by treatment with IFN-gamma but not byIFN-alpha/beta.
Journal Article
Effect of bcl-2 on fas antigen-mediated cell death
TL;DR: The results suggest that the Fas Ag and TNF receptor may share the same signaling pathway, and that bcl-2 interferes with the apoptotic process mediated by the FasAg and T NF receptor.