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Naoya Sakamoto
Researcher at Hokkaido University
Publications - 848
Citations - 20136
Naoya Sakamoto is an academic researcher from Hokkaido University. The author has contributed to research in topics: Hepatitis C virus & Medicine. The author has an hindex of 53, co-authored 784 publications receiving 16905 citations. Previous affiliations of Naoya Sakamoto include University of Michigan & Tokyo Medical and Dental University.
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Journal ArticleDOI
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.
Yasuhito Tanaka,Nao Nishida,Masaya Sugiyama,Masayuki Kurosaki,Kentaro Matsuura,Naoya Sakamoto,Mina Nakagawa,Masaaki Korenaga,Keisuke Hino,Shuhei Hige,Yoshito Ito,Eiji Mita,Eiji Tanaka,Satoshi Mochida,Yoshikazu Murawaki,Masao Honda,Akito Sakai,Yoichi Hiasa,Shuhei Nishiguchi,Asako Koike,Isao Sakaida,Masatoshi Imamura,Kiyoaki Ito,Koji Yano,Naohiko Masaki,Fuminaka Sugauchi,Namiki Izumi,Katsushi Tokunaga,Masashi Mizokami +28 more
TL;DR: A genome-wide association study to null virological response (NVR) in the treatment of patients with hepatitis C virus (HCV) genotype 1 within a Japanese population is reported.
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A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication
Andrew W. Tai,Yair Benita,Lee F. Peng,Sun Suk Kim,Naoya Sakamoto,Ramnik J. Xavier,Raymond T. Chung +6 more
TL;DR: Using a genome-wide siRNA library, 96 human genes that support HCV replication were identified, with a significant number of them being involved in vesicle organization and biogenesis andPhosphatidylinositol 4-kinase PI4KA and multiple subunits of the COPI vesicles coat complex were among the genes identified.
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Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial.
Masashi Mizokami,Osamu Yokosuka,Tetsuo Takehara,Naoya Sakamoto,Masaaki Korenaga,Hitoshi Mochizuki,Kunio Nakane,Hirayuki Enomoto,Fusao Ikeda,Mikio Yanase,Hidenori Toyoda,Takuya Genda,Takeji Umemura,Hiroshi Yatsuhashi,Tatsuya Ide,Nobuo Toda,Kazushige Nirei,Yoshiyuki Ueno,Yoichi Nishigaki,Juan Betular,Bing Gao,Akinobu Ishizaki,Masa Omote,Hongmei Mo,Kim Garrison,Phillip S. Pang,Steven J. Knox,William T. Symonds,John G. McHutchison,Namiki Izumi,Masao Omata +30 more
TL;DR: The efficacy and safety of an all-oral, fixed-dose combination of the hepatitis C virus NS5A inhibitor ledipasvir and the NS5B nucleotide polymerase inhibitor sofosbuvir with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with chronic genotype 1 hepatitis Cirus infection is assessed.
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Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs
Takanori Yokota,Takanori Yokota,Naoya Sakamoto,Nobuyuki Enomoto,Yoko Tanabe,Makoto Miyagishi,Makoto Miyagishi,Shinya Maekawa,L i Yi,Masayuki Kurosaki,Kazunari Taira,Kazunari Taira,Mamoru Watanabe,Hidehiro Mizusawa +13 more
TL;DR: The results support the feasibility of using siRNA‐based gene therapy to inhibit HCV replication, which may prove to be valuable in the treatment of hepatitis C.
Journal ArticleDOI
Hydrogen isotope ratios in lunar rocks indicate delivery of cometary water to the Moon
James P. Greenwood,Shoichi Itoh,Naoya Sakamoto,Paul H. Warren,Lawrence A. Taylor,Hisayoshi Yurimoto +5 more
TL;DR: Water has been found in many lunar rock samples, but its sources are unknown as discussed by the authors, and isotopic analyses of Apollo samples of lunar mare basalts and highlands rocks suggest that a significant volume of water was delivered to the Moon by comets shortly after its formation by giant impact.