N
Natascha Schaefer
Researcher at University of Würzburg
Publications - 32
Citations - 663
Natascha Schaefer is an academic researcher from University of Würzburg. The author has contributed to research in topics: Glycine receptor & Hyperekplexia. The author has an hindex of 11, co-authored 27 publications receiving 435 citations. Previous affiliations of Natascha Schaefer include University of Erlangen-Nuremberg.
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Journal ArticleDOI
Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students
Katarzyna Lepeta,Mychael V. Lourenco,Barbara Schweitzer,Pamela V. Martino Adami,Priyanjalee Banerjee,Silvina Catuara-Solarz,Mario de la Fuente Revenga,Alain M. Guillem,Mouna Haidar,Omamuyovwi M. Ijomone,Bettina Nadorp,Lin Qi,Nirma D Perera,Louise K. Refsgaard,Kimberley M. Reid,Mariam Sabbar,Arghyadip Sahoo,Natascha Schaefer,Rebecca K. Sheean,Anna Suska,Rajkumar Verma,Cinzia Vicidomini,Dean J. Wright,Xingding Zhang,Constanze I. Seidenbecher +24 more
TL;DR: Basic concepts of synapse structure and function are discussed, and a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders as well as neurodegenerative disorders are provided.
Journal ArticleDOI
A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels
Daniel Nahm,Franziska Weigl,Natascha Schaefer,Ana Sancho,Andreas O. Frank,Jürgen Groll,Carmen Villmann,Hans-Werner Schmidt,Paul D. Dalton,Robert Luxenhofer,Robert Luxenhofer +10 more
TL;DR: An advanced material platform based on PEtOzi is reported that is compatible with MEW and results in functionalizable chemically crosslinked microperiodic hydrogels that are compatible with confocal imaging and staining protocols for cells.
Journal ArticleDOI
GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder
Jürgen Deckert,Heike Weber,Carmen Villmann,Tina B. Lonsdorf,Jan Richter,Marta Andreatta,Alejandro Arias-Vasquez,Leif Hommers,Lindsey Kent,Christoph Schartner,Sven Cichon,Christiane Wolf,Natascha Schaefer,C. R. von Collenberg,Britta Wachter,Robert Blum,Dirk Schümann,Robert Scharfenort,Johannes Schumacher,Johannes Schumacher,Andreas J. Forstner,Andreas J. Forstner,Christian Baumann,Miriam A. Schiele,Swantje Notzon,Peter Zwanzger,Joost G. E. Janzing,Tessel E. Galesloot,Lambertus A. Kiemeney,Agnieszka Gajewska,Evelyn Glotzbach-Schoon,Andreas Mühlberger,Georg W. Alpers,Thomas Fydrich,Lydia Fehm,Alexander L. Gerlach,Tilo Kircher,Thomas Lang,Thomas Lang,Thomas Lang,Andreas Ströhle,Volker Arolt,Hans-Ulrich Wittchen,Raffael Kalisch,Christian Büchel,Alfons O. Hamm,M. M. Nöthen,M. M. Nöthen,Marcel Romanos,Katharina Domschke,Paul Pauli,Andreas Reif +51 more
TL;DR: The genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire provides evidence that non-coding, although functional GLRB gene polymorphisms may predispose to PD by increasing startle response and agoraphobic cognitions.
Journal ArticleDOI
The malleable brain: plasticity of neural circuits and behavior – a review from students to students
Natascha Schaefer,Carola Rotermund,Eva-Maria Blumrich,Mychael V. Lourenco,Pooja Joshi,Regina U Hegemann,Sumit Jamwal,Nilufar Ali,Ezra Michelet García Romero,Sorabh Sharma,Shampa Ghosh,Jitendra Kumar Sinha,Hannah Loke,Hannah Loke,Vishal Jain,Katarzyna Lepeta,Ahmad Salamian,Mahima Sharma,Mojtaba Golpich,Katarzyna Nawrotek,Ramesh Kumar Paidi,Sheila M. Shahidzadeh,Tetsadê C. B. Piermartiri,Elham Amini,Verónica Pastor,Yvette M. Wilson,Philip Adeyemi Adeniyi,Ashok Kumar Datusalia,Benham Vafadari,Vedangana Saini,Edna Suárez-Pozos,Neetu Kushwah,Paula Fontanet,Anthony J. Turner +33 more
TL;DR: A review of the role of plasticity during development and the persistent changes of neural circuitry occurring when sensory input is altered during critical developmental stages, and the signaling cascades resulting in the synthesis of new plasticity‐related proteins, which ultimately enable sustained changes in synaptic strength.
Journal ArticleDOI
Glycine receptor mouse mutants: model systems for human hyperekplexia.
TL;DR: A novel route that uses gene‐therapeutic modulation of mutated receptors to overcome loss of function mutations is described and described, which is possible to associate behavioural changes with pharmacological differences in glycinergic inhibition.