Natascia Crispino

TL;DR: Theobromine, a methylxanthine derivative present in cocoa, effectively inhibits citric acid‐induced cough in guinea‐pigs in vivo and may form the basis for a new class of antitussive drugs.

TL;DR: Analysis of inhibitory actions of cannabinoids on sensory nerve depolarisation mediated by capsaicin, hypertonic saline and PGE2 on isolated guinea‐pig and human vagus nerve preparations, and the cough reflex in conscious guinea-pigs suggests that the development of CB2 agonists, devoid of CB1‐mediated central effects, will provide a new and safe antitussive treatment for chronic cough.

TL;DR: Sensory nerves regulate central and local reflexes such as airway plasma protein leakage, bronchoconstriction and cough and may be enhanced during inflammation such that these protective effects become exacerbated and deleterious.

TL;DR: D dopamine receptor ligands inhibit depolarization of the rat and human vagus and suggest that dopamine receptor agonists may be of therapeutic benefit in the treatment of symptoms such as cough and mucus secretion which are evident in respiratory diseases such as asthma and chronic obstructive pulmonary disease.

TL;DR: In this paper , the authors discuss the rationale for using approved JAK inhibitors for treatment of peripheral PsA and their positioning in the context of EULAR/GRAPPA guidelines.