N
Natasja A. M. Kragten
Researcher at University of Amsterdam
Publications - 25
Citations - 2072
Natasja A. M. Kragten is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 16, co-authored 23 publications receiving 1561 citations.
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Journal ArticleDOI
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.
Laura K. Mackay,Laura K. Mackay,Martina Minnich,Natasja A. M. Kragten,Yang Liao,Yang Liao,Benjamin Nota,Cyril Seillet,Cyril Seillet,Ali Zaid,Kevin Man,Kevin Man,Simon Preston,Simon Preston,David Freestone,Asolina Braun,Erica Wynne-Jones,Felix M. Behr,Regina Stark,Daniel G. Pellicci,Daniel G. Pellicci,Dale I. Godfrey,Dale I. Godfrey,Gabrielle T. Belz,Gabrielle T. Belz,Marc Pellegrini,Marc Pellegrini,Thomas Gebhardt,Meinrad Busslinger,Wei Shi,Wei Shi,Francis R. Carbone,René A. W. van Lier,Axel Kallies,Axel Kallies,Klaas P. J. M. van Gisbergen +35 more
TL;DR: In this paper, the authors identify Hobit and Blimp1 as central regulators of a universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations, including NKT cells and liver-resident NK cells.
Journal Article
Hobit and Blimp1 instruct a universal transcriptional program of tissue-residency in lymphocytes
Laura K. Mackay,Martina Minnich,Natasja A. M. Kragten,Cyril Seillet,David Freestone,Gabrielle T. Belz,Meinrad Busslinger,Wei Shi,Francis R. Carbone,R. A. W. Van Lier,Axel Kallies,K van Gisbergen +11 more
TL;DR: It is shown that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trms cells in skin, gut, liver, and kidney in mice.
Journal ArticleDOI
The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants
Klaas P. J. M. van Gisbergen,Paul L. Klarenbeek,Natasja A. M. Kragten,Peter-Paul A. Unger,Marieke B. B. Nieuwenhuis,Felix M. Wensveen,Anja ten Brinke,Paul P. Tak,Eric Eldering,Martijn A. Nolte,René A. W. van Lier +10 more
TL;DR: It is proposed that CD27-driven costimulation is a strategy to generate memory clones that have potential reactivity to a wide array of mutable pathogens.
Journal ArticleDOI
T RM maintenance is regulated by tissue damage via P2RX7.
Regina Stark,Thomas H. Wesselink,Felix M. Behr,Natasja A. M. Kragten,Ramon Arens,Friedrich Koch-Nolte,Klaas P. J. M. van Gisbergen,René A. W. van Lier +7 more
TL;DR: RNA profiling revealed that TRM from liver and small intestine express P2RX7, a damage/danger-associated molecular pattern (DAMP) receptor that is triggered by extracellular nucleotides (ATP, NAD+) that reduces the persistence of tissue-resident memory T cells (TRM).
Journal ArticleDOI
Blimp‐1 homolog Hobit identifies effector‐type lymphocytes in humans
Felipe A. Vieira Braga,Kirsten M. L. Hertoghs,Natasja A. M. Kragten,Gina M. Doody,Nicholas A. Barnes,Ester B. M. Remmerswaal,Cheng-Chih Hsiao,Perry D. Moerland,Diana Wouters,Ingrid A. M. Derks,Amber van Stijn,Marc Demkes,Jörg Hamann,Eric Eldering,Martijn A. Nolte,Reuben Tooze,Ineke J. M. ten Berge,Klaas P. J. M. van Gisbergen,René A. W. van Lier +18 more
TL;DR: This paper showed that the zinc finger protein homologue of Blimp-1 in T cells (Hobit) was uniformly expressed in effector-type CD8(+) T cells, but not in naive or in most memory CD8+ T cells.