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Nathalie E. Blachère
Researcher at Howard Hughes Medical Institute
Publications - 18
Citations - 1003
Nathalie E. Blachère is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 11, co-authored 18 publications receiving 566 citations. Previous affiliations of Nathalie E. Blachère include Rockefeller University.
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Journal ArticleDOI
Vaccine Breakthrough Infections with SARS-CoV-2 Variants.
Ezgi Hacisuleyman,Caryn R Hale,Yuhki Saito,Nathalie E. Blachère,Marissa Bergh,Erin G. Conlon,Dennis Schaefer-Babajew,Justin DaSilva,Frauke Muecksch,Christian Gaebler,Richard P. Lifton,Michel C. Nussenzweig,Theodora Hatziioannou,Paul D. Bieniasz,Robert B. Darnell +14 more
TL;DR: In this paper, a cohort of 417 persons who had received the second dose of BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) vaccine at least 2 weeks previously, identified 2 women with vaccine breakthrough infection.
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FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.
Teresa Ramirez-Montagut,Nathalie E. Blachère,Elena V. Sviderskaya,Dorothy C. Bennett,Wolfgang J. Rettig,Pilar Garin-Chesa,Alan N. Houghton +6 more
TL;DR: Results show that expression of FAP is a tumor suppressor that abrogates tumorigenicity through regulation of cell growth and survival throughregulation of caspases via the intrinsic pathway.
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ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity.
Michael Moore,Nathalie E. Blachère,John J. Fak,Christopher Y. Park,Kirsty Sawicka,Salina Parveen,Ilana Zucker-Scharff,Bruno Moltedo,Alexander Y. Rudensky,Robert B. Darnell +9 more
TL;DR: A critical role is uncovered for ZFP36 RBPs in restraining T cell expansion and effector functions, and ZFP 36 inhibition is suggested as a strategy to enhance immune-based therapies.
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cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation
Hun-Way Hwang,Hun-Way Hwang,Yuhki Saito,Christopher Y. Park,Nathalie E. Blachère,Yoko Tajima,John J. Fak,Ilana Zucker-Scharff,Robert B. Darnell +8 more
TL;DR: A new platform is described, cTag-PAPERCLIP, that generates APA profiles from single cell populations in intact tissues that requires no tissue dissociation and preserves transcripts in native states, and identifies a role of APA in switching Araf protein isoforms during microglia activation, impacting production of downstream inflammatory cytokines.
Journal ArticleDOI
High-Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4.
Nathalie E. Blachère,Salina Parveen,Mayu O. Frank,Brian D. Dill,Henrik Molina,Dana E. Orange +5 more
TL;DR: This study was undertaken to determine whether rheumatoid arthritis antibodies preferentially bind PAD2‐ or PAD4‐citrullinated fibrinogen.