Nathan L. Absalom

TL;DR: Pharmacological analysis indicates that RgIA and Vc1.1 are selective antagonists of alpha9alpha10 nAChRs, a subset of peptides used offensively by carnivorous marine snails known as Conus that appear to accelerate the recovery of function after nerve injury.

TL;DR: The present study aimed to address the nature of the interaction between CBD and clobazam to address speculation that the anticonvulsant efficacy of CBD may simply reflect CBD augmenting clobzam exposure.

TL;DR: The authors' data link specific GHB forebrain binding sites with α4-containing GABAA receptors and postulate a role for extrasynaptic α4δ-containing GHB receptors in GHB pharmacology and physiology to aid in elucidating the molecular mechanisms behind the proposed function of GHB as a neurotransmitter and its unique therapeutic effects in narcolepsy and alcoholism.

TL;DR: Results indicate that loops 2 and 7 in the extracellular domain play an important role in the mechanism of activation of the glycine receptor although not by a direct electrostatic mechanism.

TL;DR: This study provides the first evidence of oxytocin having a direct, non-OTR–mediated effect on GABA–ethanol interactions, and shows a previously unidentified mechanism through which some of these effects may occur.