N
Nathan L. Yozwiak
Researcher at Broad Institute
Publications - 32
Citations - 4762
Nathan L. Yozwiak is an academic researcher from Broad Institute. The author has contributed to research in topics: Ebola virus & Human virome. The author has an hindex of 17, co-authored 29 publications receiving 3818 citations. Previous affiliations of Nathan L. Yozwiak include Redeemer's University & Harvard University.
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Journal ArticleDOI
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Stephen K. Gire,Stephen K. Gire,Augustine Goba,Kristian G. Andersen,Kristian G. Andersen,Rachel Sealfon,Rachel Sealfon,Daniel J. Park,Lansana Kanneh,Simbirie Jalloh,Mambu Momoh,Mohamed Fullah,Gytis Dudas,Shirlee Wohl,Shirlee Wohl,Lina M. Moses,Nathan L. Yozwiak,Nathan L. Yozwiak,Sarah M. Winnicki,Sarah M. Winnicki,Christian B. Matranga,Christine M. Malboeuf,James Qu,Adrianne Gladden,Stephen F. Schaffner,Stephen F. Schaffner,Xiao Yang,Pan Pan Jiang,Pan Pan Jiang,Mahan Nekoui,Mahan Nekoui,Andrés Colubri,Moinya Ruth Coomber,Mbalu Fonnie,Alex Moigboi,Michael Gbakie,Fatima K. Kamara,Veronica Tucker,Edwin Konuwa,Sidiki Saffa,Josephine Sellu,Abdul A. Jalloh,Alice Kovoma,James Koninga,Ibrahim Mustapha,Kandeh Kargbo,Momoh Foday,Mohamed Yillah,Franklyn Kanneh,Willie Robert,James L.B. Massally,Sinéad B. Chapman,James Bochicchio,Cheryl I. Murphy,Chad Nusbaum,Sarah Young,Bruce W. Birren,Donald S. Grant,John S. Scheiffelin,Eric S. Lander,Eric S. Lander,Eric S. Lander,Christian T. Happi,Sahr M. Gevao,Andreas Gnirke,Andrew Rambaut,Andrew Rambaut,Robert F. Garry,S. Humarr Khan,Pardis C. Sabeti,Pardis C. Sabeti +70 more
TL;DR: This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources.
Journal ArticleDOI
Field-deployable viral diagnostics using CRISPR-Cas13
Cameron Myhrvold,Cameron Myhrvold,Catherine A. Freije,Catherine A. Freije,Jonathan S. Gootenberg,Omar O. Abudayyeh,Hayden C. Metsky,Ann Durbin,Ann Durbin,Max J. Kellner,Amanda L Tan,Lauren M. Paul,Leda Parham,Kimberly García,Kayla G. Barnes,Kayla G. Barnes,Bridget Chak,Bridget Chak,Adriano Mondini,Maurício Lacerda Nogueira,Sharon Isern,Scott F. Michael,Ivette Lorenzana,Nathan L. Yozwiak,Nathan L. Yozwiak,Bronwyn MacInnis,Bronwyn MacInnis,Irene Bosch,Irene Bosch,Lee Gehrke,Lee Gehrke,Feng Zhang,Pardis C. Sabeti +32 more
TL;DR: The Cas13-based SHERLOCK platform can detect Zika virus and dengue virus in patient samples at concentrations as low as 1 copy per microliter and can distinguish the four DENV serotypes, as well as region-specific strains of ZIKV from the 2015–2016 pandemic.
Journal ArticleDOI
Virus genomes reveal factors that spread and sustained the Ebola epidemic
Gytis Dudas,Gytis Dudas,Luiz Max Carvalho,Trevor Bedford,Andrew J. Tatem,Guy Baele,Nuno R. Faria,Daniel J. Park,Jason T. Ladner,Armando Arias,Armando Arias,Danny Asogun,Filip Bielejec,Sarah L Caddy,Matthew Cotten,Matthew Cotten,Jonathan D'ambrozio,Simon Dellicour,Antonino Di Caro,Joseph W. Diclaro,Sophie Duraffour,Michael J. Elmore,Lawrence Fakoli,Ousmane Faye,Merle L. Gilbert,Sahr M. Gevao,Stephen K. Gire,Stephen K. Gire,Adrianne Gladden-Young,Andreas Gnirke,Augustine Goba,Donald S. Grant,Bart L. Haagmans,Julian A. Hiscox,Umaru Jah,Jeffrey R. Kugelman,Di Liu,Jia Lu,Christine M. Malboeuf,Suzanne Mate,David A. Matthews,Christian B. Matranga,Luke W. Meredith,Luke W. Meredith,James Qu,Joshua Quick,Susan D. Pas,My V. T. Phan,My V. T. Phan,Georgios Pollakis,Chantal B.E.M. Reusken,Mariano Sanchez-Lockhart,Stephen F. Schaffner,John S. Schieffelin,Rachel Sealfon,Rachel Sealfon,Etienne Simon-Loriere,Etienne Simon-Loriere,Saskia L. Smits,Kilian Stoecker,Lucy Thorne,Ekaete Alice Tobin,Mohamed A. Vandi,Simon J. Watson,Kendra West,Shannon L.M. Whitmer,Michael R. Wiley,Sarah M. Winnicki,Sarah M. Winnicki,Shirlee Wohl,Shirlee Wohl,Roman Wölfel,Nathan L. Yozwiak,Nathan L. Yozwiak,Kristian G. Andersen,Kristian G. Andersen,Sylvia O. Blyden,Fatorma K. Bolay,Miles W. Carroll,Bernice Dahn,Boubacar Diallo,Pierre Formenty,Christophe Fraser,George F. Gao,Robert F. Garry,Ian Goodfellow,Ian Goodfellow,Stephan Günther,Christian T. Happi,Edward C. Holmes,Brima Kargbo,Sakoba Keita,Paul Kellam,Paul Kellam,Marion Koopmans,Jens H. Kuhn,Nicholas J. Loman,N’Faly Magassouba,Dhamari Naidoo,Stuart T. Nichol,Tolbert Nyenswah,Gustavo Palacios,Oliver G. Pybus,Pardis C. Sabeti,Pardis C. Sabeti,Amadou A. Sall,Ute Ströher,Isatta Wurie,Marc A. Suchard,Philippe Lemey,Andrew Rambaut +110 more
TL;DR: It is revealed that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity, which will help to inform interventions in future epidemics.
Journal ArticleDOI
Research capacity. Enabling the genomic revolution in Africa
Charles N. Rotimi,Akin Abayomi,Alash'le Abimiku,Victoria Adabayeri,Clement Adebamowo,Ezekiel Adebiyi,Adebowale D. Ademola,Adebowale Adeyemo,Dwomoa Adu,Dissou Affolabi,Godfred Agongo,Samuel Ajayi,Sally N Akarolo-Anthony,Rufus Akinyemi,Albert Akpalu,Marianne Alberts,Orlando Alonso Betancourt,Ahmed M. Alzohairy,Gobena Ameni,Olukemi K. Amodu,Gabriel Anabwani,Kristian G. Andersen,Fatiu A Arogundade,Oyedunni Arulogun,Danny Asogun,Rasheed Bakare,Naby Balde,Mary Lynn Baniecki,Christine Beiswanger,Alia Benkahla,Lara Bethke,M Boehnke,Vincent Boima,James Brandful,Andrew Brooks,Frank C. Brosius,Chester W. Brown,Bruno Bucheton,David T. Burke,Barrington G. Burnett,Stacy Carrington-Lawrence,Nadia Carstens,John Chisi,Alan Christoffels,Richard S. Cooper,Heather J. Cordell,Nigel J. Crowther,Talishiea Croxton,Jantina de Vries,Leslie Derr,Peter Donkor,Seydou Doumbia,Audrey Duncanson,Ivy Ekem,Ahmed El Sayed,Mark E Engel,John Enyaru,Dean Everett,Faisal M. Fadlelmola,Eyitayo Fakunle,Kenneth H. Fischbeck,Anne Fischer,Onikepe A. Folarin,Junaid Gamieldien,Robert F. Garry,Simani Gaseitsiwe,Rasheed Gbadegesin,Anita Ghansah,Maria Y. Giovanni,Parham Goesbeck,F. Xavier Gómez-Olivé,Donald S. Grant,Ravnit Grewal,Mark S. Guyer,Neil A. Hanchard,Christian T. Happi,Scott Hazelhurst,Branwen J. Hennig,Christiane Hertz-Fowler,Winston Hide,Friedhelm Hilderbrandt,Christopher Hugo-Hamman,Muntaser E. Ibrahim,Regina James,Yasmina Jaufeerally-Fakim,Carolyn Jenkins,Ute Jentsch,Pan Pan Jiang,Moses Joloba,Victor Jongeneel,Fourie Joubert,Mukthar Kader,Kathleen Kahn,Pontiano Kaleebu,Saidi Kapiga,Samar K. Kassim,Ishmael Kasvosve,Jonathan K. Kayondo,Bernard Keavney,Adeodata Kekitiinwa,Sheik Humarr Khan,Paul L. Kimmel,Mary Claire King,Robert Kleta,Mathurin Koffi,Jeffrey B. Kopp,Matthias Kretzler,Judit Kumuthini,Samuel Kyobe,Catherine Kyobutungi,Daniel T. Lackland,Karen A. Lacourciere,Guida Landouré,Rita T. Lawlor,Thomas Lehner,Maia Lesosky,Naomi S. Levitt,Katherine Littler,Zané Lombard,Jeanne F. Loring,Sylvester Leonard Lyantagaye,Annette MacLeod,Ebony B. Madden,Chengetai R. Mahomva.,Julie Makani,Manmak Mamven,Marape Marape,Graeme Mardon,Patricia A. Marshall,Darren P. Martin,Daniel K. Masiga,Robin Mason,Michael Mate-Kole,Enock Matovu,Mary T Mayige,Mary T Mayige,Bongani M. Mayosi,Jean Claude Mbanya,Sheryl A. McCurdy,Mark I. McCarthy,Helen McIlleron,Seth O. McLigeyo,Corrine Merle,Ana Olga Mocumbi,Charles Mondo,John V. Moran,Ayesha A. Motala,Marva Moxey-Mims,Sununguko Wata Mpoloka,Chisomo L. Msefula,Thuli Mthiyane,Nicola Mulder,Gebregziabher Mulugeta,Dieuodonne Mumba,John Musuku,Mo Nagdee,Oyekanmi Nash,Daouda Ndiaye,Anh Quynh Nguyen,Mark P. Nicol,Oathokwa Nkomazana,Shane A. Norris,Betty Nsangi,Alexander K. Nyarko,Moffat Nyirenda,Eileen Obe,Reginald Obiakor,Abraham Oduro,Solomon F. Ofori-Acquah,Okechukwu S Ogah,S.W.O. Ogendo,Kwaku Ohene-Frempong,Akinlolu O. Ojo,T O Olanrewaju,John Oli,Charlotte Osafo,Odile Ouwe Missi Oukem-Boyer,Bruce Ovbiagele,Andrew Owen,Mayowa O. Owolabi,Lukman Owolabi,Ellis Owusu-Dabo,Guillaume Paré,Rulan S. Parekh,Hugh-G. Patterton,Margaret B. Penno.,Jane Peterson,Rembert Pieper,Jacob Plange-Rhule,Martin R. Pollak,Julia Puzak,Rajkumar Ramesar,Michèle Ramsay,Rebekah S. Rasooly,Shiksha Reddy,Pardis C. Sabeti,Kwamena W. Sagoe,Tunde Salako,Oumar Samassekou,Manjinder S. Sandhu,Manjinder S. Sandhu,Manjinder S. Sandhu,Osman Sankoh,Fred Stephen Sarfo,Marie Sarr,Gasnat Shaboodien,Issa Sidibe,Gustave Simo,Martin Simuunza,Liam Smeeth,Eugene Sobngwi,Himla Soodyall,Hermann Sorgho,Oumou Sow Bah,Sudha Srinivasan,Dan J. Stein,Ezra Susser,Carmen Swanepoel,Godfred Tangwa,Andrew Tareila,Özlem Tastan Bishop,Bamidele O. Tayo,Nicki Tiffin,Halidou Tinto,Ekaete Tobin,Stephen Tollman,Mahamadou Traoré,Marsha Treadwell,Jennifer L. Troyer,Masego Tsimako-Johnstone,Vincent Tukei,Ifeoma Ulasi,Nzovu Ulenga,Beverley van Rooyen,Ablo Prudence Wachinou,Salina P. Waddy,Alisha N. Wade,Misaki Wayengera,James A. G. Whitworth,Louise Wideroff,Cheryl A. Winkler,Sarah Winnicki,Ambroise Wonkam,Mengistu Tadase Yewondwossen,Nathan L. Yozwiak,Heather J. Zar +245 more
TL;DR: If the dearth of genomics research involving Africans persists, the potential health and economic benefits emanating from genomic science may elude an entire continent.
Journal ArticleDOI
Zika virus evolution and spread in the Americas
Hayden C. Metsky,Hayden C. Metsky,Christian B. Matranga,Shirlee Wohl,Shirlee Wohl,Stephen F. Schaffner,Stephen F. Schaffner,Catherine A. Freije,Catherine A. Freije,Sarah M. Winnicki,Kendra West,James Qu,Mary Lynn Baniecki,Adrianne Gladden-Young,Aaron E. Lin,Aaron E. Lin,Christopher Tomkins-Tinch,Simon Ye,Simon Ye,Daniel J. Park,Cynthia Y. Luo,Cynthia Y. Luo,Kayla G. Barnes,Kayla G. Barnes,Rickey R. Shah,Rickey R. Shah,Bridget Chak,Bridget Chak,Giselle Barbosa-Lima,Edson Delatorre,Yasmine Rangel Vieira,Lauren M. Paul,Amanda L Tan,Carolyn M. Barcellona,Mario C. Porcelli,Chalmers Vasquez,Andrew C. Cannons,Marshall R. Cone,Kelly N. Hogan,Edgar W. Kopp,Joshua J. Anzinger,Kimberly García,Leda Parham,Rosa Margarita Gelvez Ramirez,Maria Conseulo Miranda Montoya,Diana Patricia Rojas,Catherine M. Brown,Scott Hennigan,Brandon Sabina,Sarah Scotland,Karthik Gangavarapu,Nathan D. Grubaugh,Glenn Oliveira,Refugio Robles-Sikisaka,Andrew Rambaut,Andrew Rambaut,Lee Gehrke,Lee Gehrke,Sandra Smole,M. Elizabeth Halloran,M. Elizabeth Halloran,Luis Angel Villar,Salim Mattar,Ivette Lorenzana,José Cerbino-Neto,Clarissa Valim,Clarissa Valim,Wim Degrave,Patrícia T. Bozza,Andreas Gnirke,Kristian G. Andersen,Kristian G. Andersen,Sharon Isern,Scott F. Michael,Fernando A. Bozza,Thiago Moreno L. Souza,Irene Bosch,Nathan L. Yozwiak,Nathan L. Yozwiak,Bronwyn MacInnis,Bronwyn MacInnis,Pardis C. Sabeti +81 more
TL;DR: It is found that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections.