N
Nathan Mathewson
Researcher at Harvard University
Publications - 47
Citations - 3009
Nathan Mathewson is an academic researcher from Harvard University. The author has contributed to research in topics: Graft-versus-host disease & Immune system. The author has an hindex of 18, co-authored 40 publications receiving 1828 citations. Previous affiliations of Nathan Mathewson include Brigham and Women's Hospital & Broad Institute.
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Journal ArticleDOI
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial
Derin B. Keskin,Annabelle J. Anandappa,Jing Sun,Itay Tirosh,Nathan Mathewson,Shuqiang Li,Giacomo Oliveira,Anita Giobbie-Hurder,Kristen Felt,Evisa Gjini,Sachet A. Shukla,Zhuting Hu,Letitia Li,Phuong M. Le,Rosa Lundbye Allesøe,Rosa Lundbye Allesøe,Alyssa R. Richman,Monika S. Kowalczyk,Sara Abdelrahman,Jack Geduldig,Sarah Charbonneau,Kristine Pelton,J. Bryan Iorgulescu,Liudmila Elagina,Wandi Zhang,Oriol Olive,Christine McCluskey,Lars Rønn Olsen,Jonathan Stevens,William J. Lane,Andres M. Salazar,Heather Daley,Patrick Y. Wen,E. Antonio Chiocca,Maegan Harden,Niall J. Lennon,Stacey Gabriel,Gad Getz,Eric S. Lander,Aviv Regev,Jerome Ritz,Donna Neuberg,Scott J. Rodig,Keith L. Ligon,Mario L. Suvà,Kai W. Wucherpfennig,Nir Hacohen,Edward F. Fritsch,Kenneth J. Livak,Patrick A. Ott,Catherine J. Wu,David A. Reardon +51 more
TL;DR: It is demonstrated that a strategy that uses multi-epitope, personalized neoantigen vaccination, which has previously been tested in patients with high-risk melanoma, is feasible for tumours such as glioblastoma, which typically have a relatively low mutation load and an immunologically ‘cold’ tumour microenvironment.
Journal ArticleDOI
Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease.
Nathan Mathewson,Robert R. Jenq,Anna V. Mathew,Mark J. Koenigsknecht,Alan M. Hanash,Tomomi Toubai,Katherine Oravecz-Wilson,Shin Rong Wu,Yaping Sun,Corinne Rossi,Hideaki Fujiwara,Jaeman Byun,Yusuke Shono,Caroline A. Lindemans,Marco Calafiore,Thomas C. Schmidt,Kenya Honda,Vincent B. Young,Subramaniam Pennathur,Marcel R.M. van den Brink,Pavan Reddy +20 more
TL;DR: It is suggested that local and specific alteration of microbial metabolites has direct salutary effects on GVHD target tissues and can mitigate disease severity.
Journal ArticleDOI
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Mariella G. Filbin,Itay Tirosh,Itay Tirosh,Volker Hovestadt,Volker Hovestadt,McKenzie Shaw,McKenzie Shaw,Leah E. Escalante,Leah E. Escalante,Nathan Mathewson,Cyril Neftel,Nelli Frank,Kristine Pelton,Christine M. Hebert,Christine M. Hebert,Christine Haberler,Keren Yizhak,Johannes Gojo,Kristof Egervari,Christopher Mount,Peter van Galen,Peter van Galen,Dennis M. Bonal,Quang-Dé Nguyen,Alexander M. Beck,Claire Sinai,Claire Sinai,Thomas Czech,Christian Dorfer,Liliana Goumnerova,Cinzia Lavarino,Angel M. Carcaboso,Jaume Mora,Ravindra Mylvaganam,Christina C. Luo,Andreas Peyrl,Mara Popović,Amedeo A. Azizi,Tracy T. Batchelor,Matthew P. Frosch,Maria Martinez-Lage,Mark W. Kieran,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Rameen Beroukhim,Rameen Beroukhim,Gerhard Fritsch,Gad Getz,Gad Getz,Orit Rozenblatt-Rosen,Kai W. Wucherpfennig,David N. Louis,Michelle Monje,Irene Slavc,Keith L. Ligon,Keith L. Ligon,Keith L. Ligon,Todd R. Golub,Todd R. Golub,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Mario L. Suvà,Mario L. Suvà +64 more
TL;DR: This study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.
Journal ArticleDOI
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Toshiro Hara,Rony Chanoch-Myers,Nathan Mathewson,Nathan Mathewson,Chad Myskiw,Lyla Atta,Lillian Bussema,Lillian Bussema,Stephen W. Eichhorn,Stephen W. Eichhorn,Alissa C. Greenwald,Gabriela Sarti Kinker,Gabriela Sarti Kinker,Christopher Rodman,L. Nicolas Gonzalez Castro,Hiroaki Wakimoto,Orit Rozenblatt-Rosen,Xiaowei Zhuang,Xiaowei Zhuang,Jean Fan,Tony Hunter,Inder M. Verma,Kai W. Wucherpfennig,Kai W. Wucherpfennig,Aviv Regev,Aviv Regev,Mario L. Suvà,Mario L. Suvà,Itay Tirosh +28 more
TL;DR: In this paper, the mesenchymal subtype of glioblastoma is determined by both cancer cell-intrinsic alterations and extrinsic cellular interactions, but remains poorly understood.
Journal ArticleDOI
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Nathan Mathewson,Orr Ashenberg,Itay Tirosh,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Sascha Marx,Livnat Jerby-Arnon,Rony Chanoch-Myers,Toshiro Hara,Toshiro Hara,Alyssa R. Richman,Alyssa R. Richman,Yoshinaga Ito,Jason Pyrdol,Mirco Friedrich,Kathrin Schumann,Kathrin Schumann,Michael J. Poitras,Prafulla C. Gokhale,L. Nicolas Gonzalez Castro,Marni E. Shore,Marni E. Shore,Christine M. Hebert,Christine M. Hebert,Brian A. Shaw,Heather L. Cahill,Matthew Drummond,Wubing Zhang,Olamide Olawoyin,Hiroaki Wakimoto,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Priscilla K. Brastianos,X. Shirley Liu,Pamela S. Jones,Daniel P. Cahill,Matthew P. Frosch,David N. Louis,Gordon J. Freeman,Keith L. Ligon,Alexander Marson,Alexander Marson,E. Antonio Chiocca,David A. Reardon,David A. Reardon,Aviv Regev,Mario L. Suvà,Mario L. Suvà,Kai W. Wucherpfennig +49 more
TL;DR: In this paper, single-cell RNA sequencing (RNA-seq) was used to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma and IDH mutant glioma.