N
Nathan O. Stitziel
Researcher at Washington University in St. Louis
Publications - 101
Citations - 10114
Nathan O. Stitziel is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Exome sequencing & Genome-wide association study. The author has an hindex of 35, co-authored 88 publications receiving 8282 citations. Previous affiliations of Nathan O. Stitziel include University of Illinois at Chicago & Harvard University.
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Journal ArticleDOI
Loss-of-function mutations in APOC3, triglycerides, and coronary disease
Jacy R Crosby,Gina M. Peloso,Gina M. Peloso,Paul L. Auer,David R. Crosslin,Nathan O. Stitziel,Leslie A. Lange,Yingchang Lu,Zheng-Zheng Tang,He Zhang,George Hindy,Nicholas G. D. Masca,Kathleen Stirrups,Stavroula Kanoni,Ron Do,Ron Do,Goo Jun,Youna Hu,Hyun Min Kang,Chenyi Xue,Anuj Goel,Martin Farrall,Stefano Duga,Pier Angelica Merlini,Rosanna Asselta,Domenico Girelli,Oliviero Olivieri,Nicola Martinelli,Wu Yin,Dermot F. Reilly,Elizabeth K. Speliotes,Caroline S. Fox,Kristian Hveem,Oddgeir L. Holmen,Majid Nikpay,Deborah N. Farlow,Themistocles L. Assimes,Nora Franceschini,Jennifer G. Robinson,Kari E. North,Lisa W. Martin,Mark A. DePristo,Namrata Gupta,Stefan A. Escher,Jan-Håkan Jansson,Natalie R. van Zuydam,Colin N. A. Palmer,Nicholas J. Wareham,Werner Koch,Thomas Meitinger,Annette Peters,Wolfgang Lieb,Raimund Erbel,Inke R. König,Jochen Kruppa,Franziska Degenhardt,Omri Gottesman,Erwin P. Bottinger,Christopher J. O'Donnell,Bruce M. Psaty,Bruce M. Psaty,Christie M. Ballantyne,Christie M. Ballantyne,Gonçalo R. Abecasis,Jose M. Ordovas,Jose M. Ordovas,Olle Melander,Hugh Watkins,Marju Orho-Melander,Diego Ardissino,Ruth J. F. Loos,Ruth McPherson,Cristen J. Willer,Jeanette Erdmann,Alistair S. Hall,Nilesh J. Samani,Panos Deloukas,Panos Deloukas,Panos Deloukas,Heribert Schunkert,James G. Wilson,Charles Kooperberg,Stephen S. Rich,Russell P. Tracy,Danyu Lin,David Altshuler,David Altshuler,Stacey Gabriel,Deborah A. Nickerson,Gail P. Jarvik,L. Adrienne Cupples,L. Adrienne Cupples,Alexander P. Reiner,Alexander P. Reiner,Eric Boerwinkle,Sekar Kathiresan,Sekar Kathiresan +96 more
TL;DR: Rare mutations that disrupt AP OC3 function were associated with lower levels of plasma triglycerides and APOC3, and carriers of these mutations were found to have a reduced risk of coronary heart disease.
Journal ArticleDOI
A general approach to single-nucleotide polymorphism discovery
Gabor T. Marth,Ian F Korf,Mark Yandell,Raymond T. Yeh,Zhijie Gu,Hamideh Zakeri,Nathan O. Stitziel,LaDeana W. Hillier,Pui-Yan Kwok,Warren Gish +9 more
TL;DR: A unified approach to the discovery of variations in genetic sequence data of arbitrary DNA sources is presented, using the rapidly emerging genomic sequence as a template on which to layer often unmapped, fragmentary sequence data and to use base quality values to discern true allelic variations from sequencing errors.
Journal ArticleDOI
Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials
Jessica L. Mega,Nathan O. Stitziel,J. Gustav Smith,J. Gustav Smith,Daniel I. Chasman,Mark J. Caulfield,James J. Devlin,Francesco Nordio,Craig L. Hyde,Christopher P. Cannon,Frank M. Sacks,Neil Poulter,Peter S. Sever,Paul M. Ridker,Eugene Braunwald,Olle Melander,Sekar Kathiresan,Marc S. Sabatine +17 more
TL;DR: People with the highest burden of genetic risk derived the largest relative and absolute clinical benefit from statin therapy.
Journal ArticleDOI
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
Ron Do,Ron Do,Nathan O. Stitziel,Hong-Hee Won,Hong-Hee Won,Anders Berg Jørgensen,Stefano Duga,Pier Angelica Merlini,Adam Kiezun,Martin Farrall,Anuj Goel,Or Zuk,Illaria Guella,Rosanna Asselta,Leslie A. Lange,Gina M. Peloso,Gina M. Peloso,Paul L. Auer,Domenico Girelli,Nicola Martinelli,Deborah N. Farlow,Mark A. DePristo,Robert Roberts,Alex Stewart,Danish Saleheen,John Danesh,Stephen E. Epstein,Suthesh Sivapalaratnam,G. Kees Hovingh,John J.P. Kastelein,Nilesh J. Samani,Heribert Schunkert,Jeanette Erdmann,Svati H. Shah,William E. Kraus,Robert W. Davies,Majid Nikpay,Christopher T. Johansen,Jian Wang,Robert A. Hegele,Eliana Hechter,Winfried März,Winfried März,Winfried März,Marcus E. Kleber,Jie Huang,Andrew D. Johnson,Mingyao Li,Greg L. Burke,Myron D. Gross,Yongmei Liu,Themistocles L. Assimes,Gerardo Heiss,Ethan M. Lange,Aaron R. Folsom,Herman A. Taylor,Oliviero Olivieri,Anders Hamsten,Robert Clarke,Dermot F. Reilly,Wu Yin,Manuel A. Rivas,Peter Donnelly,Jacques E. Rossouw,Bruce M. Psaty,Bruce M. Psaty,David M. Herrington,James G. Wilson,Stephen S. Rich,Michael J. Bamshad,Russell P. Tracy,L. Adrienne Cupples,Daniel J. Rader,Muredach P. Reilly,John A. Spertus,Sharon Cresci,Jaana Hartiala,W.H. Wilson Tang,Stanley L. Hazen,Hooman Allayee,Alexander P. Reiner,Alexander P. Reiner,Christopher S. Carlson,Charles Kooperberg,Rebecca D. Jackson,Eric Boerwinkle,Eric S. Lander,Stephen M. Schwartz,Stephen M. Schwartz,David S. Siscovick,Ruth McPherson,Anne Tybjærg-Hansen,Gonçalo R. Abecasis,Hugh Watkins,Deborah A. Nickerson,Diego Ardissino,Shamil R. Sunyaev,Shamil R. Sunyaev,Christopher J. O'Donnell,David Altshuler,David Altshuler,Stacey Gabriel,Sekar Kathiresan,Sekar Kathiresan +103 more
TL;DR: Kathiresan et al. as mentioned in this paper used exome sequencing of nearly 10,000 people to identify alleles associated with early-onset myocardial infarction; mutations in low-density lipoprotein receptor (LDLR) or apolipoprotein A-V (APOA5) were associated with disease risk.
Journal ArticleDOI
Exome-wide association study of plasma lipids in > 300,000 individuals
Dajiang J. Liu,Gina M. Peloso,Gina M. Peloso,Haojie Yu,Adam S. Butterworth,Adam S. Butterworth,Xiao Wang,Anubha Mahajan,Danish Saleheen,Danish Saleheen,Connor A. Emdin,Connor A. Emdin,Dewan S. Alam,Alexessander Couto Alves,Philippe Amouyel,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Dominique Arveiler,Themistocles L. Assimes,Themistocles L. Assimes,Paul L. Auer,Usman Baber,Christie M. Ballantyne,Lia E. Bang,Marianne Benn,Joshua C. Bis,Michael Boehnke,Eric Boerwinkle,Eric Boerwinkle,Jette Bork-Jensen,Erwin P. Bottinger,Ivan Brandslund,Morris J. Brown,Fabio Busonero,Mark J. Caulfield,John C. Chambers,John C. Chambers,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Y. Eugene Chen,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Audrey Y. Chu,John M. C. Connell,Francesco Cucca,L. Adrienne Cupples,L. Adrienne Cupples,Scott M. Damrauer,Scott M. Damrauer,Gail Davies,Ian J. Deary,George Dedoussis,Joshua C. Denny,Anna F. Dominiczak,Marie-Pierre Dubé,Marie-Pierre Dubé,Tapani Ebeling,Gudny Eiriksdottir,Tõnu Esko,Tõnu Esko,Aliki-Eleni Farmaki,Mary F. Feitosa,Marco M Ferrario,Jean Ferrières,Ian Ford,Myriam Fornage,Paul W. Franks,Paul W. Franks,Paul W. Franks,Timothy M. Frayling,Ruth Frikke-Schmidt,Lars G. Fritsche,Philippe M. Frossard,Valentin Fuster,Valentin Fuster,Santhi K. Ganesh,Wei Gao,Melissa E. Garcia,Christian Gieger,Franco Giulianini,Mark O. Goodarzi,Harald Grallert,Niels Grarup,Leif Groop,Megan L. Grove,Vilmundur Gudnason,Torben Hansen,Torben Hansen,Tamara B. Harris,Caroline Hayward,Joel N. Hirschhorn,Joel N. Hirschhorn,Oddgeir L. Holmen,Jennifer E. Huffman,Yong Huo,Kristian Hveem,Sehrish Jabeen,Anne U. Jackson,Johanna Jakobsdottir,Marjo-Riitta Järvelin,Gorm B. Jensen,Marit E. Jørgensen,Marit E. Jørgensen,J. Wouter Jukema,Johanne Marie Justesen,Pia R. Kamstrup,Stavroula Kanoni,Fredrik Karpe,Frank Kee,Amit Khera,Amit Khera,Derek Klarin,Derek Klarin,Derek Klarin,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Charles Kooperberg,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,Claudia Langenberg,Anne Langsted,Anne Langsted,Lenore J. Launer,Torsten Lauritzen,David C. Liewald,Li-An Lin,Allan Linneberg,Ruth J. F. Loos,Yingchang Lu,Xiangfeng Lu,Xiangfeng Lu,Reedik Mägi,Anders Mälarstig,Anders Mälarstig,Ani Manichaikul,Alisa K. Manning,Alisa K. Manning,Pekka Mäntyselkä,Eirini Marouli,Nicholas G. D. Masca,Nicholas G. D. Masca,Andrea Maschio,James B. Meigs,James B. Meigs,Olle Melander,Andres Metspalu,Andrew P. Morris,Andrew P. Morris,Alanna C. Morrison,Antonella Mulas,Martina Müller-Nurasyid,Patricia B. Munroe,Matt Neville,Jonas B. Nielsen,Sune F. Nielsen,Sune F. Nielsen,Børge G. Nordestgaard,Børge G. Nordestgaard,Jose M. Ordovas,Jose M. Ordovas,Roxana Mehran,C.J. O'Donnell,C.J. O'Donnell,Marju Orho-Melander,Cliona Molony,Pieter Muntendam,Sandosh Padmanabhan,Colin N. A. Palmer,Dorota Pasko,Aniruddh P. Patel,Oluf Pedersen,Markus Perola,Markus Perola,Annette Peters,Charlotta Pisinger,Giorgio Pistis,Ozren Polasek,Ozren Polasek,Neil Poulter,Bruce M. Psaty,Bruce M. Psaty,Daniel J. Rader,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Alexander P. Reiner,Alexander P. Reiner,Frida Renström,Frida Renström,Stephen S. Rich,Paul M. Ridker,John D. Rioux,Neil R. Robertson,Neil R. Robertson,Dan M. Roden,Jerome I. Rotter,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Serena Sanna,Naveed Sattar,Naveed Sattar,Ellen M. Schmidt,Robert A. Scott,Peter S. Sever,Raquel S. Sevilla,Christian M. Shaffer,Xueling Sim,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Albert V. Smith,Blair H. Smith,Blair H. Smith,Blair H. Smith,Sangeetha Somayajula,Lorraine Southam,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kathleen Stirrups,Kathleen Stirrups,Nathan O. Stitziel,Konstantin Strauch,Heather M. Stringham,Praveen Surendran,Hayato Tada,Alan R. Tall,Hua Tang,Jean-Claude Tardif,Jean-Claude Tardif,Kent D. Taylor,Stella Trompet,Philip S. Tsao,Philip S. Tsao,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Natalie R. van Zuydam,Natalie R. van Zuydam,Anette Varbo,Anette Varbo,Tibor V. Varga,Jarmo Virtamo,Melanie Waldenberger,Nan Wang,Nicholas J. Wareham,Helen R. Warren,Peter Weeke,Peter Weeke,Joshua S. Weinstock,Jennifer Wessel,James G. Wilson,Peter W.F. Wilson,Peter W.F. Wilson,Ming Xu,Hanieh Yaghootkar,Robin Young,Eleftheria Zeggini,He Zhang,Neil S Zheng,Weihua Zhang,Yan Zhang,Wei Zhou,Yanhua Zhou,Magdalena Zoledziewska,Joanna M. M. Howson,John Danesh,John Danesh,John Danesh,Mark I. McCarthy,Mark I. McCarthy,Chad A. Cowan,Gonçalo R. Abecasis,Panos Deloukas,Panos Deloukas,Kiran Musunuru,Cristen J. Willer,Sekar Kathiresan +288 more
TL;DR: It is found that beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD), and only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and TG-lowering alleles involved in hepatic production of TG-rich lipoproteins tracked with higher liver fat, higher risk for T2D, and lower risk for CAD.