N
Nathan W. Bartlett
Researcher at University of Newcastle
Publications - 111
Citations - 6578
Nathan W. Bartlett is an academic researcher from University of Newcastle. The author has contributed to research in topics: Medicine & Rhinovirus. The author has an hindex of 33, co-authored 84 publications receiving 5476 citations. Previous affiliations of Nathan W. Bartlett include University of Oxford & Imperial College London.
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Journal ArticleDOI
Role of deficient type III interferon-λ production in asthma exacerbations
Marco Contoli,Simon D. Message,Vasile Laza-Stanca,Michael R. Edwards,Peter A. B. Wark,Peter A. B. Wark,Nathan W. Bartlett,Tatiana Kebadze,Patrick Mallia,Luminita A. Stanciu,Hayley L. Parker,Louise Slater,Anita Lewis-Antes,Onn Min Kon,Stephen T. Holgate,Donna E. Davies,Sergei V. Kotenko,Alberto Papi,Sebastian L. Johnston +18 more
TL;DR: In this paper, the authors show deficient induction of interferon-λs by rhinovirus in primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus induced asthma exacerbation and virus load in experimentally infected human volunteers.
Journal ArticleDOI
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
David A. Jackson,David A. Jackson,Heidi Makrinioti,Batika M. J. Rana,Betty Shamji,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Joseph Footitt,Joseph Footitt,Jerico del-Rosario,Jerico del-Rosario,Aurica G. Telcian,A A Nikonova,Jie Zhu,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Stephanie Traub,Jaideep Dhariwal,Jaideep Dhariwal,James D. Porter,Duncan Hunt,Toby Hunt,Trevor Hunt,Luminita A. Stanciu,Musa Khaitov,Nathan W. Bartlett,Michael R. Edwards,Onn Min Kon,Patrick Mallia,Patrick Mallia,Nikolaos G. Papadopoulos,Cezmi A. Akdis,John Westwick,Matthew J. Edwards,David J. Cousins,Ross P. Walton,Sebastian L. Johnston,Sebastian L. Johnston +38 more
TL;DR: IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Journal ArticleDOI
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense.
Mary T. Harte,Ismar R. Haga,Geraldine Maloney,Pearl Gray,Patrick C. Reading,Nathan W. Bartlett,Geoffrey L. Smith,Andrew R. Bowie,Luke A. J. O'Neill +8 more
TL;DR: V protein A52R blocks the activation of the transcription factor nuclear factor κB (NF-κB) by multiple TLRs, including TLR3, a recently identified receptor for viral RNA, providing further evidence for an important role for this family of receptors in the antiviral response.
Journal ArticleDOI
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
Julianne Stack,Ismar R. Haga,Martina Schröder,Nathan W. Bartlett,Geraldine Maloney,Patrick C. Reading,Katherine A. Fitzgerald,Geoffrey L. Smith,Andrew G. Bowie +8 more
TL;DR: The function of the vaccinia virus (VV) protein A46R is defined and it is shown it inhibits intracellular signalling by a range of Toll-like receptors (TLRs) and is functionally distinct from another described VV TLR inhibitor, A52R.
Journal ArticleDOI
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
Nathan W. Bartlett,Ross P. Walton,Michael R. Edwards,Juliya Aniscenko,Gaetano Caramori,Jie Zhu,Nicholas Glanville,Katherine Choy,Patrick Jourdan,Jerome Burnet,Tobias J. Tuthill,Michael S Pedrick,Michael Hurle,Chris Plumpton,Nigel A. Sharp,James N Bussell,Dallas M. Swallow,Jürgen Schwarze,Bruno Guy,Jeffrey Almond,Peter K. Jeffery,Clare M. Lloyd,Alberto Papi,R. A. Killington,David J. Rowlands,Edward D. Blair,Neil J. Clarke,Sebastian L. Johnston +27 more
TL;DR: Three novel mouse models of rhinovirus infection have features similar to those observed in rhinvirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations.