N
Nawajes A. Mandal
Researcher at University of Oklahoma Health Sciences Center
Publications - 54
Citations - 2121
Nawajes A. Mandal is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Retinal degeneration & Ceramide. The author has an hindex of 25, co-authored 41 publications receiving 1877 citations. Previous affiliations of Nawajes A. Mandal include University of Oklahoma & University of Michigan.
Papers
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Journal ArticleDOI
Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids
Martin-Paul Agbaga,Richard S. Brush,Nawajes A. Mandal,K. Henry,Michael H. Elliott,Robert E. Anderson +5 more
TL;DR: It is proposed that reduced VLC-PUFA in the retinas of these patients may be the cause of photoreceptor cell death, and direct and compelling evidence that ELOVL4 is required for the synthesis of C28 and C30 saturated fatty acids and C28-C38 very long chain polyunsaturated fatty acids is provided.
Journal ArticleDOI
Curcumin protects retinal cells from light-and oxidant stress-induced cell death
Nawajes A. Mandal,Jagan M.R. Patlolla,Lixin Zheng,Martin-Paul Agbaga,Julie Thu A Tran,L. D. Wicker,Anne Kasus-Jacobi,Michael H. Elliott,Chinthalapally V. Rao,Robert E. Anderson +9 more
TL;DR: Curcumin is tested in a rat model of light-induced retinal degeneration and in retina-derived cell lines to speculate that curcumin would be an effective nutraceutical compound for preventive and augmentative therapy of AMD.
Journal ArticleDOI
Mutations in TCF8 Cause Posterior Polymorphous Corneal Dystrophy and Ectopic Expression of COL4A3 by Corneal Endothelial Cells
Charles M. Krafchak,Hemant Pawar,Sayoko E. Moroi,Alan Sugar,Paul R. Lichter,David A. Mackey,David A. Mackey,Shahzad I. Mian,Theresa M. Nairus,Victor M. Elner,Miriam T. Schteingart,Catherine A. Downs,Theresa Guckian Kijek,Jenae M. Johnson,Edward H. Trager,Frank W. Rozsa,Nawajes A. Mandal,Michael P. Epstein,Douglas Vollrath,Radha Ayyagari,Michael Boehnke,Julia E. Richards +21 more
TL;DR: This study has identifiedTCF8 as the gene responsible for approximately half of the cases of PPCD, has implicated TCF8 mutations in developmental abnormalities outside the eye, and has presented the TCf8 regulatory target, COL4A3, as a key, shared molecular component of two different diseases, PPCd and Alport syndrome.
Journal ArticleDOI
Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein
TL;DR: A novel elongase, ELOVL4, involved in the synthesis of VLC-PUFA is focus on, and the importance of these FAs in maintaining the structural and functional integrity of retinal photoreceptors is focused on.
Journal ArticleDOI
Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation.
Radha Ayyagari,Nawajes A. Mandal,Athanasios J. Karoukis,Lianchun Chen,Ning C. McLaren,Mona Lichter,David Wong,Peter F. Hitchcock,Rafael C. Caruso,Sayoko E. Moroi,Irene H. Maumenee,Paul A. Sieving,Paul A. Sieving +12 more
TL;DR: A single locus at 11q23 is implicated in a complex ocular phenotype involving RPE and CE, tissues of neuroectodermal origin, and all individuals with either LAZ and/or macular degeneration carry the same CTRP5 S163R mutation, which is transmitted in autosomal dominant manner.