Naz Senvar

TL;DR: Based on a meta-analysis of studies, the KCC more accurately predicts hospital mortality among patients with AALF, whereas MELD scores more accurately predict mortalityamong patients with NAALF.

TL;DR: This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease.

TL;DR: The term acute liver failure (ALF) is frequently applied as a generic expression to describe patients presenting with or developing an acute episode of liver dysfunction, however, it refers to a highly specific and rare syndrome, characterised by an acute abnormality of liver blood tests in an individual without underlying chronic liver disease.

TL;DR: N-acetylcysteine is recommended for all patients with APAP-induced ALF and it reduces mortality and Liver transplantation should be offered early to those who are unlikely to survive based on described prognostic criteria.

TL;DR: The challenges with prognostic modeling in PALF are discussed and predictive methods that are currently available and in development for the future are described.

TL;DR: The current diagnostic and therapeutic approach to acute liver failure is reviewed, especially in the intensive care unit setting, to improve patients' outcomes and selection of patients for liver transplantation.