Author
Nazish Gul
Bio: Nazish Gul is an academic researcher from Hazara University. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 1, co-authored 2 publications receiving 191 citations.
Topics: Medicine, Gene, Steppe, Bronze Age, Nuclear chemistry
Papers
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University of Copenhagen1, Wellcome Trust Sanger Institute2, University of Cambridge3, Leiden University4, Harvard University5, Technical University of Denmark6, Al-Farabi University7, University of Chicago8, Karagandy State University9, University of Alaska Fairbanks10, Istanbul University11, Hazara University12, University of Gothenburg13, Russian Academy of Sciences14, Gazi University15, Islamia College University16, University of Exeter17, Government of Khyber Pakhtunkhwa18, Irkutsk State University19, University of Alberta20, Paul Sabatier University21, University of California, Berkeley22
TL;DR: Analysis of ancient whole-genome sequences from across Inner Asia and Anatolia shows that the Botai people associated with the earliest horse husbandry derived from a hunter-gatherer population deeply diverged from the Yamnaya, and suggests distinct migrations bringing West Eurasian ancestry into South Asia before and after, but not at the time of, YamNaya culture.
Abstract: The Yamnaya expansions from the western steppe into Europe and Asia during the Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages and possibly horse husbandry. We analyze 74 ancient whole-genome sequences from across Inner Asia and Anatolia and show that the Botai people associated with the earliest horse husbandry derived from a hunter-gatherer population deeply diverged from the Yamnaya. Our results also suggest distinct migrations bringing West Eurasian ancestry into South Asia before and after but not at the time of Yamnaya culture. We find no evidence of steppe ancestry in Bronze Age Anatolia from when Indo-European languages are attested there. Thus, in contrast to Europe, Early Bronze Age Yamnaya-related migrations had limited direct genetic impact in Asia.
273 citations
TL;DR: In this paper, the role of the TAZ domain-containing gene in response to various heavy metals was evaluated, and various in-silico approaches were applied such as duplication, phylogenetic analysis, and gene structure.
14 citations
TL;DR: Measles antibody waning in vaccinated populations should be considered in planning for measles elimination, and decreases in GMT over time were not significant after one or two doses of MCV, or after infection.
Abstract: BACKGROUND
We conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings.
METHODS
After screening 16,822 citations, we identified nine articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria.
RESULTS
Using linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received two doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% CI -212.4, -31.1) per year since vaccination over one to five years, 53.7 mIU/mL (95% CI -95.3, -12.2) five to ten years, 33.2 mIU/mL (95% CI -62.6, -3.9) ten to 15 years, and 24.1 mIU/mL (95% CI -51.5,3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after one dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after one or two doses of MCV, or after infection.
CONCLUSIONS
Measles antibody waning in vaccinated populations should be considered in planning for measles elimination.
2 citations
TL;DR: In this paper , the frequency of polycystic ovarian syndrome (PCOS) in adolescent presented to OPD due to irregular periods was found to be 7.8% patients.
Abstract: Introduction: Polycystic ovary syndrome (PCOS) is the most common cause of chronic hyper androgenic anovulation and the single most common cause of infertility in young women. Anovulatory cycles are frequent in adolescents. The common signs of adult hyperandrogenism are less reliable in adolescents than in adults: hirsutism is in a developmental phase, and acne vulgaris is common. Objective: To determine the frequency of polycystic ovary disease in adolescent presented to outdoor. Study Design and Setting: This cross sectional study was carried out in the Department of Obstetrics & Gynecology, DHQ, Zanana Hospital, Dera Ismail Khan. Duration of Study: This study was conducted from 1st July 2019 to 31st December 2019. Subjects and methods: A total of 128 girls presenting to OPD due to irregular periods were included. Ultrasound was done to all participants under supervision of consultant gynecologist of 3 years post fellow ship experience. 5 ml venous blood samples was collected from all participants by a 3rd year resident and was subsequently sent to laboratory for androgen levels. Polycystic ovary disease as per operational definition was noted. Results: Age range in this study was from 14 to 20 years with mean age of 18.195±1.29 years, mean weight 52.898±4.92 Kg, mean height 1.571±0.08 meters and mean BMI was 21.557±2.80 Kg/m2. 19.5% patients were with family history of polycystic ovary disease. Polycystic ovary disease was seen in 7.8% patients. Practical implication: To determine the frequency of polycystric ovary disease in adolescent presented to outdoor. Conclusion: Polycystic ovarian syndrome is affecting the lives of young unmarried girls. The clinical manifestations are variable with obesity playing the key role. Keywords: Adolescent, Irregular period, Polycystic ovary syndrome, Frequency
TL;DR: In this article , the physicochemical and antibacterial properties of EQUIATM coat liquid (E) after incorporation of zinc oxide (ZnO) and titanium dioxide (TiO2) nanoparticles were evaluated.
Abstract: This study evaluated the physicochemical and antibacterial properties of EQUIATM coat liquid (E) after incorporation of zinc oxide (ZnO) and titanium dioxide (TiO2) nanoparticles. ZnO and TiO2 (1 wt.% and 2 wt.%) were dispersed in EQUIA coat. Principal component analysis (PCA) and cluster analysis were performed to visualize systemic variation. Antibacterial activity was evaluated by colony-forming units and crystal violet staining using Streptococcus mutans and Lactobacillus acidophilus after 24 h, 48 h, and 72 h, and the microstructure was studied by scanning electron microscopy. The weight change was analyzed at 1 and 21 days. The PCA for TiO2- and ZnO-based groups showed 100% variance at all spectral ranges at 600–800/cm and 800–1200/cm, whereas 1200–1800/cm and 2700–3800/cm spectral regions demonstrated 99% variance. The absorbance values were significant (p < 0.05) for both nanoparticles-based adhesives, and the specimens with 2 wt.% ZnO showed the maximum response by minimum bacterial attachment, and the control group showed the least response by maximum attachment. The weight change percentage was reduced after the incorporation of antibacterial nanoparticles. It is suggested that EQUIATM coat containing nanoparticles exhibits promising results, and it may be recommended to clinically use as an improved coating material.
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Harvard University1, Broad Institute2, University of Tübingen3, Max Planck Society4, University of Mainz5, University of Washington6, University of California, Berkeley7, Massachusetts Institute of Technology8, Stockholm University9, University of Adelaide10, The Heritage Foundation11, National Museum of Natural History12, University of Edinburgh13, Sultan Qaboos University14, University of Costa Rica15, University of Antioquia16, Rambam Health Care Campus17, University of Pécs18, Al Akhawayn University19, Catholic University of the Sacred Heart20, University of Oxford21, Belgorod State University22, University of Toronto23, University of Buenos Aires24, University of Bern25, Russian Academy of Sciences26, Paul Sabatier University27, North-Eastern Federal University28, University of Chicago29, University of Arizona30, Stony Brook University31, University of Bergen32, Illumina33, Sofia Medical University34, Bashkir State University35, University of Cambridge36, Vilnius University37, Estonian Biocentre38, University of Strasbourg39, Amgen40, University College London41, Gladstone Institutes42, University of Tartu43, University of Oulu44, Muhimbili University of Health and Allied Sciences45, University of Palermo46, University of Tarapacá47, University of Chile48, Academy of Sciences of Uzbekistan49, Armenian National Academy of Sciences50, University of North Texas51, University of Santiago de Compostela52, University of Kharkiv53, Higher University of San Andrés54, Novosibirsk State University55, Leidos56, Lebanese American University57, University of Split58, University of Pennsylvania59, Banaras Hindu University60, Centre for Cellular and Molecular Biology61, Estonian Academy of Sciences62, Pompeu Fabra University63, Howard Hughes Medical Institute64
TL;DR: The authors showed that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunters-gatherer related ancestry.
Abstract: We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.
442 citations
Harvard University1, Broad Institute2, Radcliffe Institute for Advanced Study3, University of California, Berkeley4, Howard Hughes Medical Institute5, Massachusetts Institute of Technology6, Sapienza University of Rome7, University of Padua8, Queen's University Belfast9, Russian Academy of Sciences10, Al-Farabi University11, University of Pennsylvania12, University College Dublin13, University of Vienna14, Pennsylvania State University15, Max Planck Society16, Centre for Cellular and Molecular Biology17, Birbal Sahni Institute of Palaeobotany18, Emory University19, Centre national de la recherche scientifique20, Kyrgyz National University21, Altai State University22, Academy of Sciences of the Czech Republic23, University of Oxford24, South Ural State University25, Kemerovo State University26, University College London27, Northwest University (China)28, University of Pittsburgh29, Samara State University30, Chelyabinsk State University31, University of Bologna32, Academy of Sciences of Uzbekistan33, University of Winnipeg34, Simon Fraser University35, National Museum of Natural History36, Tomsk State University37, Naturhistorisches Museum38, Národní muzeum39, Hazara University40, Deccan College Post-Graduate and Research Institute41, Pompeu Fabra University42, Hartwick College43, University of California, Santa Barbara44, Washington University in St. Louis45
TL;DR: It is shown that Steppe ancestry then integrated further south in the first half of the second millennium BCE, contributing up to 30% of the ancestry of modern groups in South Asia, supporting the idea that the archaeologically documented dispersal of domesticates was accompanied by the spread of people from multiple centers of domestication.
Abstract: By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages.
354 citations
University of Copenhagen1, University of California, Berkeley2, Universidade Federal de Minas Gerais3, Technical University of Denmark4, Armenian National Academy of Sciences5, University of Alaska Fairbanks6, University of Ottawa7, University of Oxford8, University of Washington9, AmeriCorps VISTA10, University of Oregon11, Federal University of Rio de Janeiro12, Simon Fraser University13, University of Western Ontario14, University of Magallanes15, University of Texas at Austin16, University of Cambridge17, University of São Paulo18, University of Tübingen19, Kansas State University20, University of Santiago de Compostela21, University of Illinois at Urbana–Champaign22, National Park Service23, Swiss Institute of Bioinformatics24, Southern Methodist University25, Wellcome Trust Sanger Institute26
TL;DR: Analysis of the oldest genomes suggests that there was an early split within Beringian populations, giving rise to the Northern and Southern lineages, and that the early population spread widely and rapidly suggests that their access to large portions of the hemisphere was essentially unrestricted, yet there are genomic and archaeological hints of an earlier human presence.
Abstract: Studies of the peopling of the Americas have focused on the timing and number of initial migrations. Less attention has been paid to the subsequent spread of people within the Americas. We sequenced 15 ancient human genomes spanning from Alaska to Patagonia; six are ≥10,000 years old (up to ~18× coverage). All are most closely related to Native Americans, including those from an Ancient Beringian individual and two morphologically distinct "Paleoamericans." We found evidence of rapid dispersal and early diversification that included previously unknown groups as people moved south. This resulted in multiple independent, geographically uneven migrations, including one that provides clues of a Late Pleistocene Australasian genetic signal, as well as a later Mesoamerican-related expansion. These led to complex and dynamic population histories from North to South America.
211 citations
University of Copenhagen1, Russian Academy of Sciences2, Swiss Institute of Bioinformatics3, University of Bern4, University of Lisbon5, Technical University of Denmark6, University of Chicago7, Chinese Academy of Sciences8, Leiden University9, Arctic and Antarctic Research Institute10, University of Cambridge11, University of Greenland12, American Museum of Natural History13, University of Helsinki14, National Institutes of Health15, University of Illinois at Urbana–Champaign16, University of Gothenburg17, University of Turku18, Wellcome Trust Sanger Institute19, University of California, Berkeley20, Southern Methodist University21
TL;DR: Analysis of 34 newly recovered ancient genomes from northeastern Siberia reveal at least three major migration events in the late Pleistocene population history of the region, including an initial peopling by a previously unknown Palaeolithic population of ‘Ancient North Siberians’ and a Holocene migration of other East Asian-related peoples, which generated the mosaic genetic make-up of contemporary peoples.
Abstract: Northeastern Siberia has been inhabited by humans for more than 40,000 years but its deep population history remains poorly understood. Here we investigate the late Pleistocene population history of northeastern Siberia through analyses of 34 newly recovered ancient genomes that date to between 31,000 and 600 years ago. We document complex population dynamics during this period, including at least three major migration events: an initial peopling by a previously unknown Palaeolithic population of ‘Ancient North Siberians’ who are distantly related to early West Eurasian hunter-gatherers; the arrival of East Asian-related peoples, which gave rise to ‘Ancient Palaeo-Siberians’ who are closely related to contemporary communities from far-northeastern Siberia (such as the Koryaks), as well as Native Americans; and a Holocene migration of other East Asian-related peoples, who we name ‘Neo-Siberians’, and from whom many contemporary Siberians are descended. Each of these population expansions largely replaced the earlier inhabitants, and ultimately generated the mosaic genetic make-up of contemporary peoples who inhabit a vast area across northern Eurasia and the Americas. Analyses of 34 ancient genomes from northeastern Siberia, dating to between 31,000 and 600 years ago, reveal at least three major migration events in the late Pleistocene population history of the region.
211 citations
TL;DR: This study demonstrates the most deeply divergent connection between Upper Paleolithic Siberians and the First Americans and reveals human and pathogen mobility across Eurasia during the Bronze Age.
181 citations