Ned H. Kalin

Bio: Ned H. Kalin is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Amygdala & Anxiety. The author has an hindex of 78, co-authored 254 publications receiving 20241 citations. Previous affiliations of Ned H. Kalin include University of Minnesota & University of Miami.

Emotion, plasticity, context, and regulation: perspectives from affective neuroscience.

Abstract: The authors present an overview of the neural bases of emotion. They underscore the role of the prefrontal cortex (PFC) and amygdala in 2 broad approach- and withdrawal-related emotion systems. Components and measures of affective style are identified. Emphasis is given to affective chronometry and a role for the PFC in this process is proposed. Plasticity in the central circuitry of emotion is considered, and implications of data showing experience-induced changes in the hippocampus for understanding psychopathology and stress-related symptoms are discussed. Two key forms of affective plasticity are described--context and regulation. A role for the hippocampus in context-dependent normal and dysfunctional emotional responding is proposed. Finally, implications of these data for understanding the impact on neural circuitry of interventions to promote positive affect and on mechanisms that govern health and disease are considered.

Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults

Abstract: Among younger adults, the ability to willfully regulate negative affect, enabling effective responses to stressful experiences, engages regions of prefrontal cortex (PFC) and the amygdala. Because regions of PFC and the amygdala are known to influence the hypothalamic-pituitary-adrenal axis, here we test whether PFC and amygdala responses during emotion regulation predict the diurnal pattern of salivary cortisol secretion. We also test whether PFC and amygdala regions are engaged during emotion regulation in older (62- to 64-year-old) rather than younger individuals. We measured brain activity using functional magnetic resonance imaging as participants regulated (increased or decreased) their affective responses or attended to negative picture stimuli. We also collected saliva samples for 1 week at home for cortisol assay. Consistent with previous work in younger samples, increasing negative affect resulted in ventral lateral, dorsolateral, and dorsomedial regions of PFC and amygdala activation. In contrast to previous work, decreasing negative affect did not produce the predicted robust pattern of higher PFC and lower amygdala activation. Individuals demonstrating the predicted effect (decrease < attend in the amygdala), however, exhibited higher signal in ventromedial prefrontal cortex (VMPFC) for the same contrast. Furthermore, participants displaying higher VMPFC and lower amygdala signal when decreasing compared with the attention control condition evidenced steeper, more normative declines in cortisol over the course of the day. Individual differences yielded the predicted link between brain function while reducing negative affect in the laboratory and diurnal regulation of endocrine activity in the home environment.

Failure to regulate : Counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression

Abstract: Although depressed mood is a normal occurrence in response to adversity in all individuals, what distinguishes those who are vulnerable to major depressive disorder (MDD) is their inability to effectively regulate negative mood when it arises. Investigating the neural underpinnings of adaptive emotion regulation and the extent to which such processes are compromised in MDD may be helpful in understanding the pathophysiology of depression. We report results from a functional magnetic resonance imaging study demonstrating left-lateralized activation in the prefrontal cortex (PFC) when downregulating negative affect in nondepressed individuals, whereas depressed individuals showed bilateral PFC activation. Furthermore, during an effortful affective reappraisal task, nondepressed individuals showed an inverse relationship between activation in left ventrolateral PFC and the amygdala that is mediated by the ventromedial PFC (VMPFC). No such relationship was found for depressed individuals, who instead show a positive association between VMPFC and amygdala. Pupil dilation data suggest that those depressed patients who expend more effort to reappraise negative stimuli are characterized by accentuated activation in the amygdala, insula, and thalamus, whereas nondepressed individuals exhibit the opposite pattern. These findings indicate that a key feature underlying the pathophysiology of major depression is the counterproductive engagement of right prefrontal cortex and the lack of engagement of left lateral-ventromedial prefrontal circuitry important for the downregulation of amygdala responses to negative stimuli.

The Neural Substrates of Affective Processing in Depressed Patients Treated With Venlafaxine

Abstract: Objective: The purpose of this study was to use functional magnetic resonance imaging (fMRI) to probe the neural circuitry associated with reactivity to negative and positive affective stimuli in patients with major depressive disorder before treatment and after 2 and 8 weeks of treatment with venlafaxine. Relations between baseline neural activation and response to treatment were also evaluated. Method: Patients with major depressive disorder (N=12) and healthy comparison subjects (N=5) were scanned on three occasions, during which trials of alternating blocks of affective and neutral pictorial visual stimuli were presented. Symptoms were evaluated at each testing occasion, and both groups completed self-report measures of mood. Statistical parametric mapping was used to examine the fMRI data with a focus on the group-by-time interactions. Results: Patients showed a significant reduction in depressive symptoms with treatment. Group-by-time interactions in response to the negative versus neutral stimuli were found in the left insular cortex and the left anterior cingulate. At baseline, both groups showed bilateral activation in the visual cortices, lateral prefrontal cortex, and amygdala in response to the negative versus neutral stimuli, with patients showing greater activation in the visual cortex and less activation in the left lateral prefrontal cortex. Patients with greater relative anterior cingulate activation at baseline in response to the negative versus neutral stimuli showed the most robust treatment response. Conclusions: The findings underscore the importance of the neural circuitry activated by negative affect in depression and indicate that components of this circuitry can be changed within 2 weeks of treatment with antidepressant medication.

Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.

Abstract: The majority of functional neuroscience studies have focused on the brain's response to a task or stimulus. However, the brain is very active even in the absence of explicit input or output. In this Article we review recent studies examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity. Although several challenges remain, these studies have provided insight into the intrinsic functional architecture of the brain, variability in behaviour and potential physiological correlates of neurological and psychiatric disease.

Handbook of Emotions

Abstract: Part 1. Interdisciplinary Foundations. R.C. Solomon, The Philosophy of Emotions. P.N. Stearns, History of Emotions: Issues of Change and Impact. J.E. Stets, J.H. Turner, The Sociology of Emotions. J. Panksepp, The Affective Brain and Core Consciousness: How Does Neural Activity Generate Emotional Feelings? N.H. Frijda, The Psychologist's Point of View. L.S. Greenberg, The Clinical Application of Emotion in Psychotherapy. P.N. Johnson-Laird, K. Oatley, Emotions, Music, and Literature. J. Tooby, L. Cosmides, The Evolutionary Psychology of the Emotions and Their Relationship to Internal Regulatory Variables. R. Loewenstein, G. Loewenstein, The Role of Emotion in Economic Behavior. Part 2. Biological and Neurophysiological Approaches to Emotion. J.E. LeDoux, E.A. Phelps, Emotional Networks in the Brain. J.T. Larsen, G.G. Berntson, K.M. Poehlmann, T.A. Ito, J.T. Cacioppo, The Psychophysiology of Emotion. J. Bachorowski, M.J. Owren, Vocal Expressions of Emotion. D. Matsumoto, D. Keltner, M.N. Shiota, M. O'Sullivan, M. Frank, Facial Expressions of Emotion. J.M. Haviland-Jones, P.J. Wilson, A "Nose" for Emotion: Emotional Information and Challenges in Odors and Semiochemicals. T.D. Wager, L. Feldman Barrett, E. Bliss-Moreau, K. Lindquist, S. Duncan, H. Kober, J. Joseph, M. Davidson, J. Mize, The Neuroimaging of Emotion. A.D. Craig, Interoception and Emotion: A Neuroanatomical Perspective. Part 3. Developmental Changes. L.A. Camras, S.S. Fatani, The Development of Facial Expressions: Current Perspectives on Infant Emotions. M. Lewis, The Emergence of Human Emotions. P.L. Harris, Children's Understanding of Emotion. C. Saarni, The Interface of Emotional Development with Social Context. S.C. Widen, J.A. Russell, Young Children's Understanding of Others' Emotions. A.S. Walker-Andrews, Intermodal Emotional Processes in Infancy. C. Magai, Long-Lived Emotions: A Lifecourse Perspective on Emotional Development. Part 4. Social Perspectives. L.R. Brody, J.A. Hall, Gender and Emotion in Context. R.A. Shweder, J. Haidt, R. Horton, C. Joseph, The Cultural Psychology of the Emotions: Ancient and Renewed. E.R. Smith, D.M. Mackie, Intergroup Emotions. M.L. Hoffman, Empathy and Prosocial Behavior. A.H. Fischer, A.S.R. Manstead, Social Functions of Emotion. Part 5. Personality Issues. R.E. Lucas, E. Diener, Subjective Well-Being. J.E. Bates, J.A. Goodnight, J.E. Fite, Temperament and Emotion. J.J. Gross, Emotion Regulation. K.A. Lindquist, L. Feldman Barrett, Emotional Complexity. Part 6. Cognitive Factors. P. Salovey, B.T. Detweiler-Bedell, J.B. Detweiler-Bedell, J.D. Mayer, Emotional Intelligence. A.M. Isen, Some Ways in which Positive Affect Influences Decision Making and Problem Solving. N.L. Stein, M.W. Hernandez, T. Trabasso, Advances in Modeling Emotion and Thought: The Importance of Development, On-Line and Multilevel Analyses. P.M. Niedenthal, Emotion Concepts. E.A. Kensinger, D.L. Schacter, Memory and Emotion. M. Minsky, A Framework for Representing Emotional States. G.L. Clore, A. Ortony, Appraisal Theories: How Cognition Shapes Affect into Emotion. Part 7. Health and Emotions. M.A. Diefenbach, S.M. Miller, M. Porter, E. Peters, M. Stefanek, H. Leventhal, Emotions and Health Behavior: A Self-Regulation Perspective. M.E. Kemeny, A. Shestyuk, Emotions, the Neuroendocrine and Immune Systems, and Health. N.S. Consedine, Emotions and Health. A.M. Kring, Emotion Disturbances as Transdiagnostic Processes in Psychopathology. Part 8. Select Emotions. A. Ohman, Fear and Anxiety: Overlaps and Dissociations. E.A. Lemerise, K.A. Dodge, The Development of Anger and Hostile Interactions. M. Lewis, Self-Conscious Emotions: Embarrassment, Pride, Shame, and Guilt. P. Rozin, J. Haidt, C.R. McCauley, Disgust. B.L. Fredrickson, M.A. Cohn, Positive Emotions. G.A. Bonanno, L. Goorin, K.G. Coifman, Sadness and Grief.