Author
Née Halonen
Bio: Née Halonen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Indole test. The author has an hindex of 1, co-authored 1 publications receiving 23 citations.
Topics: Indole test
Papers
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27 citations
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TL;DR: In this paper, the author's version of a work that was accepted for publication in Tetrahedron is presented, and a definitive version was subsequently published in TET Volume 62, Issue 37, 11 September 2006, Pages 8655-8681.
63 citations
TL;DR: The asymmetric catalytic synthesis of beta-substituted tryptophan derivatives was realized in high diastereo- and enantioselectivity by the reaction of glycine derivatives with sulfonylindoles in the presence of catalyst derived from AgCl and a commercially available chiral monodentate phosphoramidite ligand.
56 citations
TL;DR: The first total synthesis of the C-2 symmetric indole alkaloid P-(+)-dispegatrine and four other monomeric sarpagine indoles alkaloids is described, with exclusive formation of a single atropodiastereomer 12.
Abstract: Non-phenolic oxidative coupling: The first total synthesis of the C-2 symmetric indole alkaloid P-(+)-dispegatrine (1) is reported. A late-stage thallium(III)acetate mediated intermolecular oxidative coupling was employed to construct the C(9)-C(9′) bond with complete regio- and stereocontrol. The exclusive formation of a single atropodiastereomer 12 in this critical step arises due to internal asymmetric induction, as planned. In addition, the first total synthesis of four other monomeric sarpagine indole alkaloids is described.
44 citations
TL;DR: In this article, the stereospecific total synthesis of (+)-Na-methyl-16-epipericyclivine (1) was completed [from d-(+)-tryptophan methyl ester] in an overall yield of 42%.
36 citations
TL;DR: This study provides an efficient, low-cost, and environmentally benign method for constructing such bridged frameworks, but also enriches the realm of cyclopropanol chemistry and C-H functionalization.
Abstract: Based on the discovery of copper-catalyzed cyclopropanol ring-opening addition to iminium ions, an unprecedented catalytic aerobic C-H oxidation/cyclopropanol cyclization cascade using CuCl2 as the multifunctional catalyst and air as the oxidant was developed to construct the azabicyclo[3.3.1]nonane skeleton, which is widespread in natural products and medicines. Using this method, concise asymmetric total synthesis of the indole alkaloid (-)-suaveoline was achieved. This study not only provides an efficient, low-cost, and environmentally benign method for constructing such bridged frameworks, but also enriches the realm of cyclopropanol chemistry and C-H functionalization.
33 citations