Neha Yadav

Bio: Neha Yadav is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: Epidemiology & Surface modification. The author has an hindex of 1, co-authored 5 publications receiving 2 citations.

Impact of COVID-19 on life expectancy at birth in India: a decomposition analysis.

Abstract: Background Quantifying excess deaths and their impact on life expectancy at birth (e0) provide a more comprehensive understanding of the burden of coronavirus disease of 2019 (COVID-19) on mortality. The study aims to comprehend the repercussions of the burden of COVID-19 disease on the life expectancy at birth and inequality in age at death in India. Methods The mortality schedule of COVID-19 disease in the pandemic year 2020 was considered one of the causes of death in the category of other infectious diseases in addition to other 21 causes of death in the non-pandemic year 2019 in the Global Burden of Disease (GBD) data. The measures e0 and Gini coefficient at age zero (G0) and then sex differences in e0 and G0 over time were analysed by assessing the age-specific contributions based on the application of decomposition analyses in the entire period of 2010-2020. Results The e0 for men and women decline from 69.5 and 72.0 years in 2019 to 67.5 and 69.8 years, respectively, in 2020. The e0 shows a drop of approximately 2.0 years in 2020 when compared to 2019. The sex differences in e0 and G0 are negatively skewed towards men. The trends in e0 and G0 value reveal that its value in 2020 is comparable to that in the early 2010s. The age group of 35-79 years showed a remarkable negative contribution to Δe0 and ΔG0. By causes of death, the COVID-19 disease has contributed - 1.5 and - 9.5%, respectively, whereas cardiovascular diseases contributed the largest value of was 44.6 and 45.9%, respectively, to sex differences in e0 and G0 in 2020. The outcomes reveal a significant impact of excess deaths caused by the COVID-19 disease on mortality patterns. Conclusions The COVID-19 pandemic has negative repercussions on e0 and G0 in the pandemic year 2020. It has severely affected the distribution of age at death in India, resulting in widening the sex differences in e0 and G0. The COVID-19 disease demonstrates its potential to cancel the gains of six to eight years in e0 and five years in G0 and has slowed the mortality transition in India.

Covalent attachment of streptavidin to two dimensional magnetic nanocomposite enhances surface enhancement Raman spectroscopic signal

Abstract: In this work, we report that covalently attached protein to graphene oxide/magnetite (rGO-Fe3O4) nanocomposites can act as a substrate for surface-enhanced Raman spectroscopic studies. The substrate rGO-Fe3O4 synthesized by hydrothermal process was modified with a fluorescently labeled protein, streptavidin (Strp), using silane chemistry. The modification was confirmed by confocal fluorescence microscopy and Fourier-transform infrared spectroscopy, where the fluorescence of the conjugated protein and the presence of the additional peaks were visualized, respectively. The transmission electron microscopy demonstrated a wide distribution of Fe3O4 nanoparticles on rGO sheets. In addition, when the Raman peaks of these bio-nanocomposites (rGO-Fe3O4-Strp) were compared with the GO-Strp sheets and Fe3O4-Strp nanoparticles, an active substrate-mediated surface enhancement Raman spectroscopic effect was observed. It suggests that covalently attached protein on rGO-Fe3O4 nanocomposite substrates acts as a better platform for biosensing application than bare GO sheets or Fe3O4 nanoparticles.

Borders- shaping our understanding of citizenship and immigration

Abstract: In this article, an attempt has been to focuss on Rousseau and his educational philosophy. Rousseau is called the father of modern educational theory and practice. After long experiences and struggle of life, he was become a successful writer, in the age of 38 years. At Geneva ,he had simple ,happy and pure life. He was emerged as revolutionary philosopher. His philosophy was based on a reaction against the contemporary social and political set up. He was a philosopher, writer and composer whose political philosophy influenced the France revolution and the development of liberal conservative and socialist theory. He was made important contribution to music as theorist and a composer. He was written two major books,Du contract social, principles du droit politique in April, then Emile or on education in May. The books criticized religion and were banned in France and Geneva. He was born in Geneva on June 28,1712 and in 1778 died in Paris. He remained vagabond for a long time. His important writing are (1) progress of the art and sciences (2) the origin of inequality Among Men.(3) social contract (4) Emile or concerning education. During his life he were attempted so many occupations like private tutor, music tutor, composer secretary and dramatist. He was become a successful writer at the age of 38. His full name is Jean Jacques Rousseau. He was of dignity of man. He was naturalist. He said that “civilized man borns,lives and dies in a state of slavery”

Bi-functionalization of glass surfaces with poly-l-lysine conjugated silica particles and polyethylene glycol for selective cellular attachment and proliferation

Abstract: Fabrication of microstructured patterns serves as a powerful tool for studying the cellular responses toward synthetic materials at the material–cell interface for tissue engineering. Silica particles can effectively act as a substrate for cellular attachment and growth owing to its biocompatible nature and facile surface chemistry. In the current study, a non-lithographic microfabrication method for patterning of particles was devised using silica particles (~ 600 nm) and epoxy-silane-functionalized glass surfaces. Poly-l-lysine (PLL) was covalently attached to modified silica particles which were subsequently patterned onto the functionalized glass surfaces. PLL played a dual role. Firstly, it served as a bi-linker by covalently attaching modified particles on epoxy functionalized glass surfaces. Secondly, it facilitated cellular attachment on the pattern via electrostatic interactions. The vacant unpatterned regions were passivated with methoxy-polyethylene glycol-amino (MPA) to avoid non-specific cellular attachments. A549 cells were found to grow specifically on the monolayered silica patterns having lower packing density and exhibited stretched morphology, indicating cellular attachment to the substrate, whereas the MPA passivated areas were capable of blocking cell adhesion successfully. The highlight of the reported novel method lies in the dual use of PLL which not only provided necessary control over the surface chemistry by allowing fabrication of desired patterns but also facilitated selective cellular attachment on the generated patterns. Therefore, we report a simple process for micropatterning the cells on desired patterns via surface bi-functionalization for selective cellular attachment and proliferation.

Life expectancy changes since COVID-19

Abstract: Abstract The COVID-19 pandemic triggered an unprecedented rise in mortality that translated into life expectancy losses around the world, with only a few exceptions. We estimate life expectancy changes in 29 countries since 2020 (including most of Europe, the United States and Chile), attribute them to mortality changes by age group and compare them with historic life expectancy shocks. Our results show divergence in mortality impacts of the pandemic in 2021. While countries in western Europe experienced bounce backs from life expectancy losses of 2020, eastern Europe and the United States witnessed sustained and substantial life expectancy deficits. Life expectancy deficits during fall/winter 2021 among people ages 60+ and <60 were negatively correlated with measures of vaccination uptake across countries ( r 60+ = −0.86; two-tailed P < 0.001; 95% confidence interval, −0.94 to −0.69; r <60 = −0.74; two-tailed P < 0.001; 95% confidence interval, −0.88 to −0.46). In contrast to 2020, the age profile of excess mortality in 2021 was younger, with those in under-80 age groups contributing more to life expectancy losses. However, even in 2021, registered COVID-19 deaths continued to account for most life expectancy losses.

Bounce backs amid continued losses: Life expectancy changes since COVID-19

Abstract: Background The COVID-19 pandemic triggered an unprecedented rise in mortality that translated into life expectancy losses around the world, with only a few exceptions. In 2021, life expectancy trends globally diverged more due to the unequal impact of the pandemic across countries, variation in the age-patterns of mortality, and differences in vaccination. We estimate life expectancy changes in 29 countries since 2020, attribute them to mortality changes by age group, and compare them to historic life expectancy shocks. Data Total death counts by age and sex came from the Short-term Mortality Fluctuations and Human Mortality databases. Registered COVID-19 deaths and vaccination counts by age and sex were sourced from the COVerAGE-DB database. Midyear population counts were extracted from the UN World Population Prospects database. Methods Life expectancy for females, males, and the total population were calculated for 29 countries for 2020 and 2021. Additionally, we calculated life expectancy deficits for 2020 and 2021 based on pre-pandemic Lee-Carter forecasts of short-term life expectancy trends. Using demographic decomposition techniques, age- and COVID-19 specific contributions to changes and deficits in life expectancy were calculated. Deficits in life expectancy in 2021 across countries were compared to country vaccination rates. 95% uncertainty intervals were derived from Poisson replications of death counts. Findings Out of 29 countries, 14 countries lost life expectancy in both 2020 and 2021, 12 recovered losses in 2020 but not all of them back to 2019 levels, 2 exceeded pre-pandemic life expectancy, and 1 dropped below 2019 levels only in 2021. All 29 countries had lower life expectancy in 2021 than expected had pre-pandemic trends continued. The female life expectancy advantage increased for most countries, consistent with hypotheses that females are more resilient to mortality crises than men. Life expectancy losses were moderately correlated with measures of vaccination uptake. One notable change from 2020 was that mortality at younger ages contributed more to life expectancy losses in 2021. Registered COVID-19 deaths accounted for most losses of life expectancy. Interpretation In 2021 we saw divergence in the impact of the pandemic on population health. While some countries saw bounce-backs from stark life expectancy losses, others experienced sustained and substantial life expectancy deficits. While COVID-19 has been the most severe global mortality shock since the Second World War, this observed heterogeneity in 2021 indicates that pathways to long-term recovery of life expectancy trends remain unclear.

Social Determinants of Remaining Life Expectancy at Age 60: A District-Level Analysis in Germany

Abstract: Remaining life expectancy at age 60 (in short: RLE) is an important indicator of the health status of a population’s elders. Until now, RLE has not been thoroughly investigated at the district level in Germany. In this study we analyzed, based on recent publicly available data (2015–2017), and for men and women separately, how large the RLE differences were in Germany across the 401 districts. Furthermore, we examined a wide range of potential social determinants in terms of their bivariate and multivariate (i.e., partial) impact on men’s and women’s RLE. Men’s district-level RLE ranged between 19.89 and 24.32 years, women’s district-level RLE between 23.67 and 27.16 years. The best single predictor both for men’s and women’s RLE at district level was ‘proportion of employees with academic degree’ with standardized partial regression coefficients of 0.42 (men) and 0.51 (women). Second and third in rank were classic economic predictors, such as ‘household income’ (men), ‘proportion of elder with financial elder support’ (women), and ‘unemployment’ (men and women). Indicators expressing the availability of medical services and staffing levels of nursing homes and services had at best a marginal partial impact. This study contributes to the growing body of evidence that a population’s educational level is a decisive determinant of population health resp. life expectancy in contemporary industrialized societies.

Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties

Abstract: Nanosized ZnO particles with diameters of 15 nm were prepared with a solution precipitation method at low cost and high yield. The synthesis of the particles was functionalized by the organic solvent dimethylformamide, and the particles were covalently bonded to the surface of graphene oxide. The morphology of the graphene oxide sheets and ZnO particles was confirmed with field emission scanning electron microscopy and biological atomic force microscopy. Fourier transform infrared spectroscopy and X-ray diffraction were used to analyze the physical and chemical properties of the ZnO/graphene oxide composites that differed from those of the individual components. Enhanced electrochemical properties were detected with cyclic voltammetry, with a redox peak of the composites at 0.025 mV. Excellent antibacterial activity of ZnO/graphene oxide composites was observed with a microdilution method in which minimum inhibitory concentrations of 6.25 µg/mL for Escherichia coli and Salmonella typhimurium, 12.5 µg/mL for Bacillus subtilis, and 25 µg/mL for Enterococcus faecalis. After further study of the antibacterial mechanism, we concluded that a vast number of reactive oxygen species formed on the surface of composites, improving antibacterial properties.