Neil Benson

TL;DR: Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription.

TL;DR: Application of systems pharmacology can now impact across all stages of drug research and development, and has the potential to become an integral component of a new ‘enhanced quantitative drug discovery and development’ (EQD3) R&D paradigm.

TL;DR: The role model‐based drug development approaches can and do play in accelerating and optimizing compound development strategies through a series of illustrative examples are discussed.

TL;DR: In this article, a model of the nuclear factor, κB (NF-κB) signalling pathway, containing 64 parameters and 26 variables, including steps in which the activation of the NF-κb transcription factor is intimately associated with the phosphorylation and ubiquitination of its inhibitor by a membrane-associated kinase, and its translocation from the cytoplasm to the nucleus.

TL;DR: Analysis of dynamic models of part of the NF-kappaB signalling pathway reveals a level of complexity in these dynamic models that is not apparent from study of their individual parameters alone and point to the value of manipulating multiple elements of complex networks to achieve desired physiological effects.