N
Neil D. Pearson
Researcher at GlaxoSmithKline
Publications - 60
Citations - 2039
Neil D. Pearson is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Carbenoid & Ketone. The author has an hindex of 20, co-authored 59 publications receiving 1764 citations. Previous affiliations of Neil D. Pearson include Trinity University & University of Bristol.
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Journal ArticleDOI
Type IIA topoisomerase inhibition by a new class of antibacterial agents.
Benjamin D. Bax,Pan F. Chan,Drake S. Eggleston,Drake S. Eggleston,Andrew P. Fosberry,Daniel R. Gentry,Fabrice Gorrec,Fabrice Gorrec,Ilaria Giordano,Michael M. Hann,Alan Joseph Hennessy,Martin Hibbs,Jianzhong Huang,Emma J. Jones,Jo J. Jones,Kristin K. Brown,Ceri J. Lewis,Earl May,Earl May,Martin R. Saunders,Onkar M. P. Singh,Claus Spitzfaden,Carol Shen,Anthony Shillings,Andrew J. Theobald,Alexandre Wohlkonig,Alexandre Wohlkonig,Neil D. Pearson,Michael N. Gwynn +28 more
TL;DR: This work provides new insights into the mechanism of topoisomerase action and a platform for structure-based drug design of a new class of antibacterial agents against a clinically proven, but conformationally flexible, enzyme class.
Journal ArticleDOI
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance
Alexandre Wohlkonig,Pan F. Chan,Andrew P. Fosberry,Paul Homes,Jianzhong Huang,Michael Kranz,Vaughan R. Leydon,Timothy J. Miles,Neil D. Pearson,Rajika L. Perera,Anthony Shillings,Michael N. Gwynn,Benjamin D. Bax +12 more
TL;DR: A crystal structure of moxifloxacin in complex with Acinetobacter baumannii topoisomerase IV now shows the wedge-shaped quinolone stacking between base pairs at the DNA cleavage site and binding conserved residues in theDNA cleavage domain through chelation of a noncatalytic magnesium ion.
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Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Kerrie E. McNally,Rebecca A. Faulkner,Florian Steinberg,Matthew Gallon,Rajesh Ghai,David Pim,Paul F. Langton,Neil D. Pearson,Chris M. Danson,Heike Nägele,Lindsey L. Morris,Amika Singla,Brittany L. Overlee,Kate J. Heesom,Richard B. Sessions,Lawrence Banks,Brett M. Collins,Imre Berger,Daniel D. Billadeau,Ezra Burstein,Peter J. Cullen +20 more
TL;DR: The discovery of an ancient and conserved multiprotein complex that orchestrates cargo retrieval and recycling and, importantly, is biochemically and functionally distinct from the established retromer pathway is described.
Journal ArticleDOI
RNA as a drug target.
TL;DR: Recent advances in the fields of RNA synthesis, structure determination and therapeutic target identification make the systematic exploitation of RNA as a drug target a realistic goal.
Journal ArticleDOI
Asymmetric rhodium carbenoid insertion into the si-h bond
Richard T. Buck,Michael P. Doyle,Martin James Drysdale,Leigh Ferris,David C. Forbes,David Haigh,Christopher J. Moody,Neil D. Pearson,Qi-Lin Zhou +8 more
TL;DR: In this paper, a chiral dirhodium(II) catalyst was used for insertion of the intermediate carbenoid with varying degrees of enantioselectivity (up to 47% ee).