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Neil Stone
Researcher at University College Hospital
Publications - 41
Citations - 1627
Neil Stone is an academic researcher from University College Hospital. The author has contributed to research in topics: Medicine & Fluconazole. The author has an hindex of 14, co-authored 34 publications receiving 1073 citations. Previous affiliations of Neil Stone include St George's Hospital & Liverpool School of Tropical Medicine.
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Journal ArticleDOI
Cryptococcus: from environmental saprophyte to global pathogen.
TL;DR: Recent discoveries that illustrate the intricacy of host–pathogen interactions and reveal new details about the host immune responses that either help to protect against disease or increase host susceptibility are described.
Journal ArticleDOI
Liposomal Amphotericin B (AmBisome ® ): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions
TL;DR: LAmB is a formulation that results in reduced toxicity as compared with DAmB while retaining the antifungal effect of the active agent, and its long terminal half-life and retention in tissues suggest that single or intermittent dosing regimens are feasible.
Journal ArticleDOI
Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa
Síle F. Molloy,Cecilia Kanyama,Robert S. Heyderman,Angela Loyse,Charles Kouanfack,Duncan Chanda,Sayoki Mfinanga,Elvis Temfack,Shabir Lakhi,Sokoine Lesikari,Adrienne K. Chan,Neil Stone,Newton Kalata,Natasha Karunaharan,Katherine M Gaskell,Mary Peirse,Jayne Ellis,Chimwemwe Chawinga,Sandrine Lontsi,Jean-Gilbert Ndong,Philip Bright,Duncan Lupiya,Tao Chen,John S. Bradley,Jack Adams,Charles van der Horst,Joep J. van Oosterhout,Victor Sini,Yacouba Mapoure,Peter Mwaba,Tihana Bicanic,David G. Lalloo,Duolao Wang,Mina C. Hosseinipour,Olivier Lortholary,Shabbar Jaffar,Tom Harrison +36 more
TL;DR: Two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widely used fluconazole monotherapy were tested.
Journal ArticleDOI
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial
Guy E. Thwaites,Matthew Scarborough,Alexander J. Szubert,Emmanuel Nsutebu,Robert Tilley,Julia Greig,S A Wyllie,Peter R. Wilson,Cressida Auckland,Janet Cairns,Denise Ward,Pankaj Lal,Achyut Guleri,Neil Jenkins,Julian Sutton,Martin Wiselka,Gonzalez-Ruiz Armando,Clive Graham,Paul R. Chadwick,Gavin Barlow,N. Claire Gordon,Bernadette C. Young,Sarah Meisner,Paul McWhinney,David Price,David Harvey,Deepa Nayar,Dakshika Jeyaratnam,Tim Planche,Jane Minton,Fleur Hudson,Susan Hopkins,John Williams,M. Estée Török,Martin J Llewelyn,Jonathan D. Edgeworth,A. Sarah Walker,A. Sarah Walker,Musa Kamfose,Ana de Veciana,Nicola Claire Gordon,Leon Peto,Gemma Pill,Tiphanie Clarke,Laura Watson,Dai Griffiths,Ali Vaughn,Luke Anson,Elian Liu,Sanuki Perera,Lydia Rylance-Knight,Carmen Cantell,Ruth Moroney,G. Thwaites,Karen Bisnauthsing,Antonio Querol-Rubiera,Charlotte Gibbs,Amita Patel,Carolyn Hemsley,Anna L. Goodman,Duncan Wyncoll,Jason Biswas,Jennifer Fitzpatrick,Lizzie Roberts,James Millard,Neil Stone,Angela Cape,Lisa Hurley,Chi Kai Tam,Marie-Claire Hoyle,Kate Maitland,Leona Trainor,Helen Reynolds,Jennifer Harrison,Jim Anson,Joseph M. Lewis,Jonathan Folb,Lynsey Goodwin,Nicholas J. Beeching,Sarah Dyas,Helen Winslow,Elizabeth Foote,Paul B. Roberts,Pavithra Natarajan,Alex Chrdle,Manuel Fenech,Hannah Allsop,Rachel Austin-Hutchison,Louise Barrett,Karen Brookes,Leanne Carwithen,Andrew Conbeer,R. Cunningham,Charlotte Eglinton,Rosie Fok,Hannah Gott,Shona Hughes,Lewis Jones,Maggie Kalita,Angela King,Linda March,Mike Marner,Tracey Mynes,Aiden Plant,Suzanne Price,Judy Sercombe,Alison Stolton,Mark Wallis,Marie-Claire West,Jackie Westcott,Claire Williams,Rob Wosley,Leona Yabsley,Laura Butland,Julie Sorrell,Tamara Mitchell,Abiola Alli,James E Meiring,Boingotlo Masake,Carlene Rowson,Lynne Smart,Laura Makey,Sarah Moll,Jane Cunningham,Kim Ryalls,Kathryn Birchall,Janet Middle,Yvonne Jackson,Diane Swift,Joby Cole,Bala Subramanian,Faith Okhuoya,Maria Edwards,Cheryl Bailey,Rebecca Warren,Gayti Islam,Michael Ankcorn,Sarah Birchall,Paul W. Jones,John Humphries,Stephen Booth,Cariad Evan,Sarah A Wyllie,Andrew Flatt,Lenka Strakova,Maria Hayes,Stacey Valentine,Clare James,Mary Wands,Nicolas Cortes,Nisa Khan,Robert Porter,Zoe Martin,Keith Yip,Helen Preedy,Helen Chesterfield,Tracey Dobson,Colin Walker,Martin J. Llewelyn,Angela Dunne,Laura Latter,Alison Porges,James I. Price,John Paul,Laura Behar,Louise Robinson,Amy Murray,Tenessa Sargent,Carrie Ridley,Laura Ortiz-Ruiz de Gordoa,Deborah Gilliam,Carole McPherson,Simon Matthews,Emma Foreman,Rajesh Jarghese,Alisha Beddoe,Sebastien Martin,Sephora Shaw,Dominika Wlazly,Maggie Cole,Abraham Gihawi,Kevin Cole,Theodore Gouliouris,Luke Bedford,Rebecca B. Saunderson,Ilias Mariolis,Rachel Bousfield,Isobel Ramsay,Daniel Greaves,Sani H. Aliyu,Kim Cox,Lois Mlemba,Lynne Whitehead,Naval Vyse,Mark Bolton,Pauline Lambert,David Chadwick,Kirsty Baillie,Martyn Cain,Richard Bellamy,Jason Wong,Jane Thompson,Helen Vassallo,Agnieszka Skotnicka,Andrea Boyce,Anthony Donnelly,Graham FitzGerald,Victoria Dean,Kristian Warnes,Anna Reyes,Saadia Rahman,Lillian Tsang,Joanne Williams,Stephen Morris-Jones,Elen Witness,Orla Brady,Elizabeth Woodford,Teresa Pettifer,Angela McCadden,Ben Marks,Sophie Collier,Damien Mack,Simon Warren,Colin S Brown,Adrian Lyons,Sara Taiyari,Stephen Mepham,Anna Sweeney,Li-An K Brown,Alison Potter,Jess Mandiza,Maxine Hough,Sue Williams,Caroline Renton,Fiona Walters,Maria Nadolski,Andree Evans,Polly Tarrant,Katherine Curley,Sophie Whiteley,Julia Halpin,Melanie Hutchings,Shirley Todd,Christop Lohan,Tamika Chapter,Emma Folland,A. Colville,Katy Marden,Marina Morgan,Rob Porter,Mel Baxter,Sarah Rippon,Muge Cevik,Judith Chapman,Tim Kemp,Rachel Vincent,Dave Osborne,Tracey Platt,James Calderwood,Bernadette Cook,Caroline Bedford,Leanne Galloway-Browne,Nadine Abberley,Kelly Attack,Joanna Allen,Melanie Harrison,Sarah Stevenson,Carol Brooks,Paula Harlow,Jordan Ewing,Shirley Cooper,Roderick Balancio-Tolentino,Laura O'Neil,Rebecca Tagney,Daniela Shackcloth,James Fellows,Ruth Millett,Jo Studham,Cherrelle de Souza,Geoffrey Howell,Hezron Greaves,Ella Foncel,Rahul Kurup,Jack Briggs,Melody Smith,Cristina Suárez,Giordana Sorrentino,Antonia I Scobie,Angela Houston,Fozia Ahmad,Aodhan Breathnach,Rakhee Chahuan,Katie Wilkins,Natalia Waddington,Rashmi Sharma,Peter Flegg,Veenu Kollipara,Mazhar Alam,Andrew Potter,Stacey Donaldson,Charlote Armer,Julie Frudd,Manju Joy,Asha Mathews,Stephen K Glass,Ayodele Ajayi,Amanda Fife,Saba Qaiser,Sharon Sheehan,Sergio Muñoz-Villaverde,Noah Yogo,Ines De Abreu,Gaynor Notcheva,Joanna Flanagan,Cordelia Watson,Efisia Sais,Adetunji Adedayo,Vicky Chu,Georgina Shaw,Michelle A Graver,Rebecca Palmer,Donna Palmer,Senait Haile,Joanne Gordon,Kirandip Mandar,Weronika Szypura,Josephine Marange,Vusumuzi Shabangu,Katy Moore,Jill Lyons,Melinda Munang,Mirriam Sangombe,Ed Moran,Abid Hussain,Adam Lewszuk,Sally Batham,Kate Ellis,Leila Bahadur,Helena A White,Manish Pareek,Amandip Sahota,Stephen Coleman,Hilary Pateman,Atul Kotecha,Christopher Sim,Andy Rosser,Jill Deane,Richard Nendick,Catherine Aldridge,Anne Clarke,Michelle Wood,Adele Marshall,Lynsey Stephenson,Tracy Matheson-Smith,John Sloss,Kathryn Potts,Joanne Malkin,Lemonia Ftika,Veena Raviprakash,Ahalya K. Malachira,Miranda Kean,Kristine Criste,Kirsty Gladas,Caroline Andrews,Clare Hutchison,Ellen Adams,Janet Andrews,Belinda Romans,Nicola Ridley,Melanie Ekani,Julie Mitchell,Nicola Smith,Tristan W Clark,Sarah Glover,Robert M. Reed,Tat Yam,Holly Burton,Rasha Said,Amy Janvier,Reni Jacob,Chris Smalley,Alison Fair,Susan Lord,Kate Ripalda,Helen Wooldridge,Luis Cotter,Gus Cardoso,Elaine Strachan,Gagan Kaler,Adam Mohamoodally,Emma Lawrence,Zoe Prime,Rachel Abrahams,David A Price,Lesley Rigden,Laura Shewan,Katherine Cullen,Ingrid Emmerson,Karen Martin,Hesther Wilson,Charley Higham,Kathryn Louise Taylor,Edmund Ong,Bijal Patel,Helena Bond,Janine Gradwell,John Widdrington,Sarah Thornthwaite,Scott prentice,Una Poultney,Hannah Crowther,Helen Fairlamb,Emily Hetherington,Chris Brewer,Suryabrata Banerjee,Clare Hamson,Anna McSkeane,Paula Sharratt,Joanne Thorpe,Sue Kimachia,Helen Wilson,Benjamin Jeffs,Leslie Masters,Jonathan Wilson,Judith Platt,Lisa Burgess,Paul J. Chadwick,Adam Jeans,Claire Keatley,Amanda Moran,Zoe Swann,Katherine Pagett,Alex Peel,Jason Howard,Kate Maloney,Avril Masdin,Louise Wright,Samantha Crossman,Vicki Lowthorpe,Emma Moore,Peter Moss,Angela Parkin,Adam Wolstencroft,Bev Warner,Clare Tarbotton,Alison Eyre,Anne B. M. Anderson,Tina Burdett,Amy Driffill,AS Walker,Alex Szubert,Helen Webb,Charlotte Russell,Brooke Jackson,Damilola Otiko,Chiara Borg,Lindsey Masters,Zaheer Islam,Carlos Díaz-Montaña,Debbie Johnson +459 more
TL;DR: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia in this multicentre, randomised, double-blind, placebo-controlled trial.
Journal ArticleDOI
Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis
Neil Stone,Johanna Rhodes,Matthew C. Fisher,Sayoki Mfinanga,Sayoki Mfinanga,Sokoine Kivuyo,Joan Rugemalila,Ella Shtifman Segal,Leor Needleman,Síle F. Molloy,June Kwon-Chung,Thomas S. Harrison,William W. Hope,Judith Berman,Tihana Bicanic +14 more
TL;DR: These findings demonstrate for what is believed to be the first time the presence and emergence of aneuploidy-driven FLC heteroresistance in human CM, association of efflux levels withheteroresistance, and the successful suppression of heterores resistance with 5FC/FLC combination therapy.