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Nelly Malenkovich
Researcher at Harvard University
Publications - 7
Citations - 8589
Nelly Malenkovich is an academic researcher from Harvard University. The author has contributed to research in topics: T cell & CD28. The author has an hindex of 5, co-authored 7 publications receiving 7693 citations.
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Journal ArticleDOI
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Gordon J. Freeman,Andrew J. Long,Yoshiko Iwai,Karen Bourque,Tatyana Chernova,Hiroyuki Nishimura,Lori Fitz,Nelly Malenkovich,Taku Okazaki,Michael C. Byrne,Heidi F. Horton,Lynette A. Fouser,Laura L. Carter,Vincent Ling,Michael R Bowman,Beatriz M. Carreno,Mary Collins,Clive Wood,Tasuku Honjo +18 more
TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.
Journal ArticleDOI
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Yvette Latchman,Clive Wood,Tatyana Chernova,Divya Chaudhary,Madhuri Borde,Irene Chernova,Yoshiko Iwai,Andrew J. Long,Julia A. Brown,Raquel A. Nunes,Edward A. Greenfield,Karen Bourque,Vassiliki A. Boussiotis,Laura L. Carter,Beatriz M. Carreno,Nelly Malenkovich,Hiroyuki Nishimura,Taku Okazaki,Tasuku Honjo,Arlene H. Sharpe,Gordon J. Freeman +20 more
TL;DR: These studies show overlapping functions of PD-L1 andPD-L2 and indicate a key role for the PD- L–PD-1 pathway in regulating T cell responses.
Journal ArticleDOI
ICOS is critical for CD40-mediated antibody class switching
Alexander J. McAdam,Rebecca J. Greenwald,Michele A. Levin,Tatyana Chernova,Nelly Malenkovich,Vincent Ling,Gordon J. Freeman,Arlene H. Sharpe +7 more
TL;DR: Mice lacking ICOS exhibit profound deficits in immunoglobulin isotype class switching, accompanied by impaired germinal centre formation, and class switching was restored in ICOS-/- mice by CD40 stimulation, showing that ICOS promotes T-cell/B-cell collaboration through the CD40/CD40L pathway.
Journal ArticleDOI
Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells
Alexander J. McAdam,Alexander J. McAdam,Tammy T. Chang,Anna E. Lumelsky,Edward A. Greenfield,Vassiliki A. Boussiotis,Jonathan S. Duke-Cohan,Tatyana Chernova,Nelly Malenkovich,Claudia Jabs,Vijay K. Kuchroo,Vincent Ling,Mary Collins,Arlene H. Sharpe,Gordon J. Freeman +14 more
TL;DR: Investigating the role of ICOS in activation of CD4+ T cells and its role in Th responses demonstrated that ICOS stimulation is important in T cell activation and thatICOS may have a particularly important role in development of Th2 cells.
Patent
Pd-l2 molecules: novel pd-1 ligands and uses therefor
TL;DR: In this article, isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1.