Neuza Domingues

TL;DR: It is shown that QAC-induced toxicity is mediated primarily through mitochondrial dysfunction in mammalian columnar epithelial cell cultures in vitro, and lethal effects are shown to be primarily a result of this process.

TL;DR: The data show that short chain (C12) n-alkyl pyridinium bromides have a sufficiently large therapeutic window to be good microbicide candidates.

TL;DR: Using oxidized low density lipoproteins and its oxidized cholesteryl esters and phospholipid constituents to stimulate macrophage has been hugely valuable, however there is now an argument that only working with low complexity lipid species can deliver the most useful information to guide therapies aimed at controlling atherosclerosis and cardiovascular complications.

TL;DR: A non-equilibrium reaction quotient, Q′, describing the global homeostasis of cholesterol as manifested in the blood plasma was shown to have a value in the CVD cohorts that was about one third less than in the control cohort, suggesting its potential use as a rapid predictive/diagnostic measure of CVD-related irregularities in cholesterolHomeostasis.

TL;DR: It was demonstrated that VO(dmpp)2 significantly enhances [3-(3)H]-glucose uptake by W and GK rat adipocytes and reduces the increase of PTP1β expression in GK animals, showing an efficacy similar to insulin 1.72 nM and better than the same concentration of BMOV.