Neville Firth

TL;DR: The characteristics of the major types of mobile genetic elements involved in acquisition and spread of antibiotic resistance in both Gram-negative and Gram-positive bacteria are outlined, focusing on the so-called ESKAPEE group of organisms, which have become the most problematic hospital pathogens.

TL;DR: Using multiphoton intravital microscopy, it is shown that neutrophils extravasate from inflamed dermal venules in close proximity to perivascular macrophages, which are a major source of neutrophil chemoattractants.

TL;DR: The 46.4-kb nucleotide sequence of pSK41 has been determined, representing the first completely sequenced conjugative plasmid from a gram-positive organism, and has provided insights into the evolution of a clinically significant group of plasmids.

TL;DR: This study demonstrates how MRSA can persist in a region through the reintroduction of a previously unrecognized distinct clade and demonstrates the crucial adaptive responses of HA-MRSA to the highly selective environment of the health care system, the evolution of MRSA isolate to even higher levels of antibiotic resistance at the cost of attenuated virulence.

TL;DR: The structure of the pSK41 segrosome revealed in the crystal structure of a ParR-DNA complex was described in this paper, where the 20-mer tandem repeats stack pseudo-continuously to generate the full-length centromere with the ribbon-helix-helikehelix fold of ParR binding successive DNA repeats as dimer-of-dimers.