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Nhan Trung Nguyen

Bio: Nhan Trung Nguyen is an academic researcher from Vietnam National University, Ho Chi Minh City. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 22, co-authored 81 publications receiving 1386 citations. Previous affiliations of Nhan Trung Nguyen include University of Lyon & Ho Chi Minh City University of Science.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the formation of through-wafer metal plugs using the copper electroplating technique was investigated, and the one-side Cu plating and bottom-up filling appeared to be the most suitable technique for copper filling into high aspect ratio vias.
Abstract: Through-wafer electrical connections are becoming increasingly important for three-dimensional integrated circuits, microelectromechanical systems packaging and radio-frequency components In this paper, we report our current results on the formation of through-wafer metal plugs using the copper electroplating technique Several approaches for via filling are investigated, such as filling before or after wafer thinning Among the methods experimented, the one-side Cu plating and bottom-up filling appears to be the most suitable technique for copper filling into high aspect ratio vias Using this method, we demonstrate the successful filling of vias with an aspect ratio of up to 7 Copper plugs as small as 20 × 20 μm2 are obtained uniformly over 4 inch Si wafers

135 citations

Journal ArticleDOI
TL;DR: Findings indicate that ZNF217 mRNA expression may represent a novel prognostic biomarker in breast cancer and therapeutic targeting of Z NF217 of the TGF-β signaling pathway may benefit the subset of patients whose tumors express high levels of ZNF 217.
Abstract: The Kruppel-like zinc finger protein ZNF217 is a candidate oncogene in breast cancer. In this study, we showed that high levels of expression of ZNF217 mRNA are associated with poor prognosis and the development of metastases in breast cancer. Overexpression of ZNF217 in breast cancer cells stimulated migration and invasion in vitro and promoted the development of spontaneous lung or node metastases in mice in vivo. ZNF217 also promoted epithelial-mesenchymal transition (EMT) in human mammary epithelial cells, and the TGF-β-activated Smad signaling pathway was identified as a major driver of ZNF217-induced EMT. In addition, a TGF-β autocrine loop sustained activation of the TGF-β pathway in ZNF217-overexpressing mammary epithelial cells, most likely because of ZNF217-mediated direct upregulation of TGFB2 or TGFB3. Inhibition of the TGF-β pathway led to the reversal of ZNF217-mediated EMT. Together, our findings indicate that ZNF217 mRNA expression may represent a novel prognostic biomarker in breast cancer. Therapeutic targeting of ZNF217 of the TGF-β signaling pathway may benefit the subset of patients whose tumors express high levels of ZNF217.

107 citations

Journal ArticleDOI
TL;DR: Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC(50) values less than 10 microg/ml.

101 citations

01 Jan 2003
TL;DR: Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 extracts had antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparumstrain FCR-3 with EC50 values less than 10g/ml.
Abstract: Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparumstrain FCR-3 with EC50 values less than 10g/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratumhad the strongest antiplasmodial activity with EC50 value of 0.5g/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.

93 citations

Journal ArticleDOI
TL;DR: Chemical investigation of these extracts led to isolation of nineteen compounds, i.
Abstract: The H2O, H2O/MeOH (1 : 1) and MeOH extracts of the wood of Taxus yunnanensis possessed significant DPPH radical scavenging and nitric oxide (NO) inhibitory activities. Chemical investigation of these extracts led us to isolation of nineteen compounds, i. e., five lignans, two simple phenolics, and twelve taxane-type diterpenes. Isotaxiresinol and seco-isolariciresinol, two major lignans of the wood, possessed potent DPPH radical scavenging activities with IC 50 values of 21.7 and 28.9 microM, respectively. Similarly, coniferyl aldehyde, taxusin, 10-deacetyltaxuyunnanine C, hongdoushan A, and 2alpha,5alpha,10beta-triacetoxy-14beta-[( S)-2-methylbutyryloxy]-4(20),11-taxadiene showed potent NO inhibitory activity with IC 50 values of 18.0, 22.1, 28.5, 15.0 and 26.4 microM, respectively, which were either equal or lower than the positive control NG-monomethyl- L-arginine ( L -NMMA) with an IC 50 value of 28.5 microM.

61 citations


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01 Jan 2006

3,012 citations

Journal ArticleDOI
TL;DR: It is shown that polyphenols can play a beneficial role in the prevention and the progress of chronic diseases related to inflammation such as diabetes, obesity, neurodegeneration, cancers, and cardiovascular diseases, among other conditions.
Abstract: This review offers a systematic understanding about how polyphenols target multiple inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear understanding of the molecular mechanisms of action of phenolic compounds. Polyphenols regulate immunity by interfering with immune cell regulation, proinflammatory cytokines’ synthesis, and gene expression. They inactivate NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and modulate mitogen-activated protein Kinase (MAPk) and arachidonic acids pathways. Polyphenolic compounds inhibit phosphatidylinositide 3-kinases/protein kinase B (PI3K/AkT), inhibitor of kappa kinase/c-Jun amino-terminal kinases (IKK/JNK), mammalian target of rapamycin complex 1 (mTORC1) which is a protein complex that controls protein synthesis, and JAK/STAT. They can suppress toll-like receptor (TLR) and pro-inflammatory genes’ expression. Their antioxidant activity and ability to inhibit enzymes involved in the production of eicosanoids contribute as well to their anti-inflammation properties. They inhibit certain enzymes involved in reactive oxygen species ROS production like xanthine oxidase and NADPH oxidase (NOX) while they upregulate other endogenous antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione (GSH) peroxidase (Px). Furthermore, they inhibit phospholipase A2 (PLA2), cyclooxygenase (COX) and lipoxygenase (LOX) leading to a reduction in the production of prostaglandins (PGs) and leukotrienes (LTs) and inflammation antagonism. The effects of these biologically active compounds on the immune system are associated with extended health benefits for different chronic inflammatory diseases. Studies of plant extracts and compounds show that polyphenols can play a beneficial role in the prevention and the progress of chronic diseases related to inflammation such as diabetes, obesity, neurodegeneration, cancers, and cardiovascular diseases, among other conditions.

803 citations

Journal ArticleDOI
TL;DR: This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.
Abstract: Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.

546 citations

Journal ArticleDOI
TL;DR: The available animal models of diabetes and some in vitro models which have been used as tools to investigate the mechanism of action of drugs with potential antidiabetic properties are reviewed to contribute to the researcher in the ethnopharmacology field to designs new strategies for the development of novel drugs to treat this serious condition.

299 citations